{"id":"https://openalex.org/W2363431389","doi":null,"title":"Effects of pravastatin on nitric oxide production in endothelial progenitor cells","display_name":"Effects of pravastatin on nitric oxide production in endothelial progenitor cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2363431389","mag":"2363431389"},"language":"en","primary_location":{"id":"mag:2363431389","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-YXSJ201102011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764451629","display_name":"The Journal of Pharmaceutical Practice","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Pharmaceutical Practice","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079630485","display_name":"Xiao Gang-feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiao Gang-feng","raw_affiliation_strings":["~1,ZHANG Huai-qin~2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"~1,ZHANG Huai-qin~2","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5079630485"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3236758,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pravastatin","display_name":"pravastatin","score":1.0},{"id":"https://openalex.org/keywords/endothelial-progenitor-cells","display_name":"endothelial progenitor cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.925000011920929},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/enos-mrna-expression","display_name":"eNOS mRNA expression","score":0.8320000171661377},{"id":"https://openalex.org/keywords/acetylated-ldl-uptake","display_name":"acetylated LDL uptake","score":0.7850000262260437},{"id":"https://openalex.org/keywords/endothelial-function","display_name":"endothelial function","score":0.9229999780654907},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2779519902","wikidata":"https://www.wikidata.org/wiki/Q1240093","display_name":"Pravastatin","level":3,"score":0.890362024307251},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.8258129358291626},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.7672576904296875},{"id":"https://openalex.org/C5362183","wikidata":"https://www.wikidata.org/wiki/Q410200","display_name":"Ficoll","level":4,"score":0.7337489128112793},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.67461758852005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.543133556842804},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.500124454498291},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.48632344603538513},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.4853605031967163},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4547831118106842},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3987724781036377},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39374715089797974},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.3801911175251007},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3543959856033325},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2828046977519989},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27997440099716187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24177056550979614},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2392788827419281},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2341797947883606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21015003323554993},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.09468004107475281}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2363431389","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-YXSJ201102011.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764451629","display_name":"The Journal of Pharmaceutical Practice","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Pharmaceutical Practice","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2368048455","https://openalex.org/W4234843260","https://openalex.org/W2561142751","https://openalex.org/W2007390691","https://openalex.org/W2017991095","https://openalex.org/W2169537677","https://openalex.org/W2138220494","https://openalex.org/W2094352959","https://openalex.org/W2373833631","https://openalex.org/W2013574967"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,56,60,66,84,97,103],"effects":[4],"of":[5,34,63,68,81,86,88,99,105],"pravastatin":[6,89],"on":[7],"nitric":[8,70,100],"oxide":[9,71,101],"production":[10,98],"in":[11,30,108],"endothelial":[12,69],"progenitor":[13],"cells.":[14],"Methods":[15],"Total":[16],"mononuclear":[17],"cells(MNCs)":[18],"were":[19,37,47,74],"isolated":[20],"from":[21],"peripheral":[22],"blood":[23,112],"by":[24,49],"Ficoll":[25],"density":[26],"gradient":[27],"centrifugation,and":[28],"cultured":[29],"vitro.After":[31],"7":[32],"days":[33],"culture.attached":[35],"cells":[36,46],"stimulated":[38],"with":[39,77],"pravastatin(10":[40],"and":[41,51,54,65,83,102],"100\u03bcmol/L)":[42],"for":[43],"48":[44],"h.The":[45],"identified":[48],"immuno-histochemistry":[50],"flow":[52],"cytometry":[53],"tested":[55],"ability":[57],"to":[58],"intake":[59],"acLDL.The":[61],"content":[62,80],"NO":[64,82],"level":[67,85],"synthase(eNOS)":[72],"mRNA":[73,107],"tested.Results":[75],"Compared":[76],"control":[78],"group,the":[79],"eNOS":[87,106],"group":[90],"increased":[91],"obviously(P0.05":[92],").Conclusions":[93],"Pravastatin":[94],"could":[95,110],"increase":[96],"expression":[104],"EPCs,which":[109],"improve":[111],"vessel":[113],"endothelium":[114],"function.":[115]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
