{"id":"https://openalex.org/W2363368832","doi":null,"title":"Expression and Function Analysis of Cholinergic Components nAChR\u03b17 in Preadipocytes","display_name":"Expression and Function Analysis of Cholinergic Components nAChR\u03b17 in Preadipocytes","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2363368832","mag":"2363368832"},"language":"en","primary_location":{"id":"mag:2363368832","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SWHZ200809005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100737657","display_name":"Jing Wu","orcid":"https://orcid.org/0000-0001-9861-4323","observed_orcids":["https://orcid.org/0000-0001-9861-4323","https://orcid.org/0009-0002-2465-4140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Wu","raw_affiliation_strings":["),LU Hui-Ling1),HU Xiu-Fen1),LIANG Xiao-Yan1),LIN Han-Hua1),WANG Hong-Wei1),YANG Yang2),XIA Zhi1)"],"raw_orcid":"https://orcid.org/0000-0001-9861-4323","affiliations":[{"raw_affiliation_string":"),LU Hui-Ling1),HU Xiu-Fen1),LIANG Xiao-Yan1),LIN Han-Hua1),WANG Hong-Wei1),YANG Yang2),XIA Zhi1)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397405","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-6612-8865","observed_orcids":["https://orcid.org/0000-0001-6612-8865"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6612-8865","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063820583","display_name":"Zhi Xia","orcid":"https://orcid.org/0000-0002-5596-8137","observed_orcids":["https://orcid.org/0000-0002-5596-8137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi Xia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5596-8137","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.8521000146865845,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-neuronal-cholinergic-system","display_name":"non-neuronal cholinergic system","score":0.9240000247955322},{"id":"https://openalex.org/keywords/preadipocytes","display_name":"preadipocytes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/adipocytes","display_name":"adipocytes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/visfatin","display_name":"visfatin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/3t3-l1-cells","display_name":"3T3-L1 cells","score":0.8519999980926514},{"id":"https://openalex.org/keywords/methyllycaconitine","display_name":"methyllycaconitine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.8989999890327454},{"id":"https://openalex.org/keywords/choline-chloride","display_name":"choline chloride","score":0.9710000157356262},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2780374058","wikidata":"https://www.wikidata.org/wiki/Q3333710","display_name":"Methyllycaconitine","level":5,"score":0.9624291658401489},{"id":"https://openalex.org/C198399640","wikidata":"https://www.wikidata.org/wiki/Q14863671","display_name":"Choline acetyltransferase","level":3,"score":0.8461354970932007},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6641523838043213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6540830135345459},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.6522543430328369},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6508236527442932},{"id":"https://openalex.org/C142536801","wikidata":"https://www.wikidata.org/wiki/Q4636414","display_name":"3T3-L1","level":4,"score":0.6272805333137512},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5781946778297424},{"id":"https://openalex.org/C2779570518","wikidata":"https://www.wikidata.org/wiki/Q412256","display_name":"Nicotinic acetylcholine receptor","level":4,"score":0.5752217173576355},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.5047494173049927},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.495550274848938},{"id":"https://openalex.org/C188987157","wikidata":"https://www.wikidata.org/wiki/Q7030581","display_name":"Nicotinic agonist","level":3,"score":0.48699766397476196},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.4594936668872833},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4316803514957428},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3532552123069763},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.30531853437423706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29817795753479004},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2005423903465271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16201382875442505},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1610482931137085},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.07713049650192261},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2363368832","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SWHZ200809005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1932093217","https://openalex.org/W1993620441","https://openalex.org/W2012973306","https://openalex.org/W2021739875","https://openalex.org/W2028769335","https://openalex.org/W2031611689","https://openalex.org/W2042871890","https://openalex.org/W2068081524","https://openalex.org/W2084622089","https://openalex.org/W2089872313","https://openalex.org/W2089917328","https://openalex.org/W2091568425","https://openalex.org/W2121845219","https://openalex.org/W2135110328","https://openalex.org/W2138476689","https://openalex.org/W2143076349","https://openalex.org/W2161605623","https://openalex.org/W2169382147","https://openalex.org/W2169714980","https://openalex.org/W2215629512"],"related_works":["https://openalex.org/W2390243047","https://openalex.org/W2387674036","https://openalex.org/W970533850","https://openalex.org/W2169714980","https://openalex.org/W2066666501","https://openalex.org/W4237725726","https://openalex.org/W1816880077","https://openalex.org/W2359829827","https://openalex.org/W2373683424","https://openalex.org/W2366269314"],"abstract_inverted_index":{"The":[0],"non-neuronal":[1],"cholinergic":[2],"system,widely":[3],"exists":[4],"in":[5,14,23,35,49,101,127,132],"prokaryotic,eukarytic,and":[6],"even":[7],"plant":[8],"cells,however,it":[9],"has":[10],"not":[11],"been":[12],"investigated":[13],"preadipocytes":[15,24,51,103,129],"and":[16,25,32,43,65,90,130],"adipocytes.To":[17],"search":[18],"for":[19,63,88],"evidence":[20],"its":[21],"existence":[22],"adipocytes,the":[26],"nicotinic":[27],"acetylcholine":[28],"receptor(nAChR)":[29],"\u03b17":[30,123],"subunit,acetylcholinesterase(AChE)":[31],"choline":[33],"acetyltransferase(ChAT)":[34],"3T3-L1":[36,50,102,128],"cells":[37],"were":[38],"examined":[39],"using":[40],"immunohistochemical":[41],"staining":[42],"Western":[44],"blotting.The":[45],"choline-regulated":[46],"visfatin":[47,70,94,99,133],"expression":[48,71,100],"was":[52,113,120,125],"also":[53],"tested":[54],"by":[55,107],"reverse":[56],"transcriptase-PCR.Incubation":[57],"with":[58,75,81,118],"methyllycaconitine(10-6":[59],"to":[60,85,109],"10-4":[61,86],"mol/L)":[62,87],"12,24":[64,89],"36":[66,91,105],"hours":[67,80,92,106],"dose-dependently":[68],"increased":[69],"from":[72],"1.3-to":[73],"1.55-folds(P0.01)":[74],"maximal":[76],"induction":[77],"at":[78,104],"24":[79],"10-4mol/L":[82],"methyllycaconitine.Nicotine":[83],"treatments(10-6":[84],"decreased":[93],"expression;choline":[95],"chloride(10-4":[96],"mol/L))":[97],"suppressed":[98],"1.64":[108],"2.03":[110],"fold(P0.05)":[111],"which":[112],"more":[114],"effective":[115],"as":[116],"compared":[117],"nicotine.It":[119],"concluded":[121],"that":[122],"nAChR":[124],"expressed":[126],"involved":[131],"expression.":[134]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}