{"id":"https://openalex.org/W2363201181","doi":null,"title":"[Effects of microinjection of L-arginine into the depressor area of ventral surface of medulla oblongata on cardiovascular responses].","display_name":"[Effects of microinjection of L-arginine into the depressor area of ventral surface of medulla oblongata on cardiovascular responses].","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W2363201181","mag":"2363201181","pmid":"https://pubmed.ncbi.nlm.nih.gov/21171404"},"language":"zh","primary_location":{"id":"pmid:21171404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21171404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Wang","raw_affiliation_strings":["Department of Physiology, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112574388","display_name":"J Y Pan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Y Pan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5046533154","display_name":"Jia Bj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Jia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26135493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"153","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.4018999934196472,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.38179999589920044,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.059300001710653305,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9240000247955322},{"id":"https://openalex.org/keywords/medulla-oblongata","display_name":"medulla oblongata","score":0.8949999809265137},{"id":"https://openalex.org/keywords/central-blood-pressure-regulation","display_name":"central blood pressure regulation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/glutamatergic-neurotransmission","display_name":"glutamatergic neurotransmission","score":0.7870000004768372},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.7480000257492065},{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.8429999947547913},{"id":"https://openalex.org/keywords/renal-perfusion-pressure","display_name":"renal perfusion pressure","score":0.7049999833106995},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pressor-response","display_name":"pressor response","score":0.628000020980835},{"id":"https://openalex.org/keywords/microinjection","display_name":"microinjection","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.9912029504776001},{"id":"https://openalex.org/C2778110749","wikidata":"https://www.wikidata.org/wiki/Q189033","display_name":"Medulla oblongata","level":3,"score":0.7551541328430176},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.5920416116714478},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.560050368309021},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4544508755207062},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.44930320978164673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43038254976272583},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42274340987205505},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.41328197717666626},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40637439489364624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38486361503601074},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.36098718643188477},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33821460604667664},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24152520298957825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17333438992500305},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.06063339114189148},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002319","descriptor_name":"Cardiovascular System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008526","descriptor_name":"Medulla Oblongata","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008845","descriptor_name":"Microinjections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21171404","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21171404","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2389467526","https://openalex.org/W2385835261","https://openalex.org/W2390122364","https://openalex.org/W2135079348","https://openalex.org/W2003336689","https://openalex.org/W992842495","https://openalex.org/W2011345447","https://openalex.org/W1989113925","https://openalex.org/W3212053508","https://openalex.org/W2127299825"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"study":[2,51],"the":[3,10,20,42,52,144,152,158,162,169,181],"effects":[4,53],"of":[5,12,28,41,54,56,66,91,99,165],"L-arginine,":[6],"a":[7,173],"precursor":[8],"for":[9],"synthesis":[11],"nitric":[13],"oxide,":[14],"when":[15],"it":[16],"was":[17,130],"microinjected":[18],"into":[19,60,72,104,119,143],"functionally":[21],"identified":[22],"depressor":[23,122,128],"area":[24],"in":[25,86,157,161,176,180],"ventral":[26],"surface":[27],"medulla":[29],"oblongata":[30],"(VSMd)":[31],"on":[32],"cardiovascular":[33],"responses.":[34],"METHODS:":[35],"Artery":[36],"pressure":[37,40,167],"(AP),":[38],"perfusion":[39],"kidney":[43],"(PPK)":[44],"and":[45,79,111,168],"heart":[46,87],"rate":[47],"were":[48],"recorded":[49],"to":[50],"microinjection":[55,65,98,115,137],"NO":[57,155],"related":[58,133],"drugs":[59],"VSMd.":[61],"RESULTS:":[62],"(1)":[63],"Unilateral":[64,114],"L-arginine":[67,138,153],"(60":[68,139],"-":[69,140,154],"100":[70,141],"nmol)":[71,94,103,118,142],"VSMd":[73,105,120,159],"produced":[74],"prominent":[75],"dose-related":[76],"pressor":[77],"effect":[78,123,129],"increased":[80],"PPK":[81],"but":[82],"without":[83],"significant":[84],"changes":[85],"rate.":[88],"(2)":[89],"Microinjection":[90],"L-Arg":[92],"(100":[93],"3":[95],"min":[96],"after":[97],"methylene":[100],"blue":[101],"(10":[102],"did":[106],"not":[107],"significantly":[108,131],"change":[109],"AP":[110],"PPK.":[112],"(3)":[113],"L-glutamate":[116],"(350":[117],"elicited":[121],"(-34.97%":[124],"+/-":[125],"4.33%).":[126],"The":[127],"dosed":[132],"attenuated":[134],"by":[135],"prior":[136],"same":[145],"area.":[146],"CONCLUSION:":[147],"These":[148],"results":[149],"suggest":[150],"that":[151],"pathway":[156,170],"participate":[160],"central":[163],"regulation":[164],"artery":[166],"may":[171],"have":[172],"key":[174],"role":[175],"inhibiting":[177],"glutamatergic":[178],"neurotransmission":[179],"anesthetized":[182],"rats.":[183]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}
