{"id":"https://openalex.org/W2363071679","doi":"https://doi.org/10.3760/cma.j.issn.1673-4378.2007.05.023","title":"Advance in molecular genetics for malignant hyperthermia","display_name":"Advance in molecular genetics for malignant hyperthermia","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2363071679","doi":"https://doi.org/10.3760/cma.j.issn.1673-4378.2007.05.023","mag":"2363071679"},"language":"en","primary_location":{"id":"mag:2363071679","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWMZ200705026.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764984328","display_name":"Guoji mazuixue yu fusu zazhi","issn_l":"1673-4378","issn":["1673-4378"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Guoji mazuixue yu fusu zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064336304","display_name":"Wang Jun-k","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"\u5415\u9ec4\u4f1f","raw_affiliation_strings":["110001,\u6c88\u9633,\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u9ebb\u9189\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"110001,\u6c88\u9633,\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u9ebb\u9189\u79d1","institution_ids":["https://openalex.org/I4210140515"]}]},{"author_position":"last","author":{"id":null,"display_name":"\u738b\u4fca\u79d1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140515","display_name":"First Hospital of China Medical University","ror":"https://ror.org/04wjghj95","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140515"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"\u738b\u4fca\u79d1","raw_affiliation_strings":["110001,\u6c88\u9633,\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u9ebb\u9189\u79d1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"110001,\u6c88\u9633,\u4e2d\u56fd\u533b\u79d1\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u9ebb\u9189\u79d1","institution_ids":["https://openalex.org/I4210140515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064336304"],"corresponding_institution_ids":["https://openalex.org/I4210140515"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"05","first_page":"460","last_page":"463"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.21469999849796295,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-hyperthermia","display_name":"malignant hyperthermia","score":1.0},{"id":"https://openalex.org/keywords/ryr1-gene","display_name":"RYR1 gene","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.9300000071525574},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7070000171661377},{"id":"https://openalex.org/keywords/volatile-anesthetics","display_name":"volatile anesthetics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/depolarizing-muscle-relaxants","display_name":"depolarizing muscle relaxants","score":0.9819999933242798},{"id":"https://openalex.org/keywords/autosomal-dominant-inheritance","display_name":"autosomal dominant inheritance","score":0.8379999995231628},{"id":"https://openalex.org/keywords/gene-structure","display_name":"gene structure","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2776333580","wikidata":"https://www.wikidata.org/wiki/Q18031340","display_name":"RYR1","level":4,"score":0.9966657161712646},{"id":"https://openalex.org/C2778575482","wikidata":"https://www.wikidata.org/wiki/Q1585081","display_name":"Malignant hyperthermia","level":2,"score":0.9680788516998291},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.7117288112640381},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6576700210571289},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6352052092552185},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5806699991226196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5178430676460266},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4234866797924042},{"id":"https://openalex.org/C2909765735","wikidata":"https://www.wikidata.org/wiki/Q4116663","display_name":"Muscle disorder","level":2,"score":0.41841793060302734},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2487829327583313},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2145610749721527},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17302671074867249},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1134345531463623}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:2363071679","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWMZ200705026.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764984328","display_name":"Guoji mazuixue yu fusu zazhi","issn_l":"1673-4378","issn":["1673-4378"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Guoji mazuixue yu fusu zazhi","raw_type":null},{"id":"mag:3030649477","doi":"https://doi.org/10.3760/cma.j.issn.1673-4378.2007.05.023","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN32176120072805/369745.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764984328","display_name":"Guoji mazuixue yu fusu zazhi","issn_l":"1673-4378","issn":["1673-4378"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Guoji mazuixue yu fusu zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2122382220","https://openalex.org/W6978979216","https://openalex.org/W7105639648","https://openalex.org/W2150763524","https://openalex.org/W1526621118","https://openalex.org/W1924509038","https://openalex.org/W2356882945","https://openalex.org/W2615661946","https://openalex.org/W2105366496","https://openalex.org/W1978854369"],"abstract_inverted_index":{"Malignant":[0],"hyperthermia":[1],"(MH)":[2],"is":[3,26],"an":[4],"autosomal-dominant":[5],"inherited":[6],"musculoskeletal":[7],"disorder":[8],"triggered":[9],"by":[10],"volatile":[11],"an-":[12],"esthetics":[13],"or":[14],"depolarizing":[15],"muscle":[16,31],"relaxants":[17],"in":[18,37],"genetically":[19],"predisposed":[20],"individuals.Recent":[21],"studies":[22],"suggest":[23],"that":[24],"MH":[25],"associated":[27],"to":[28],"skele-":[29],"tal":[30],"ryanodine":[32],"receptor":[33],"(RyR1)":[34],"gene":[35,45,50,61],"mutation":[36,51],"hereditary.We":[38],"reviewed":[39],"herein":[40],"the":[41,54],"characteristic":[42],"of":[43,56],"RYR1":[44],"structure,the":[46],"correlation":[47],"between":[48],"RyR1":[49,60],"and":[52],"MH,and":[53],"effect":[55],"some":[57],"anesthetics":[58],"on":[59],"mutation.":[62]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}