{"id":"https://openalex.org/W2362987367","doi":null,"title":"The influence of Pseudomonas aeruginosa biofilm suspension and alginate on macrophage phagocytosis function in mouse","display_name":"The influence of Pseudomonas aeruginosa biofilm suspension and alginate on macrophage phagocytosis function in mouse","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2362987367","mag":"2362987367"},"language":"en","primary_location":{"id":"mag:2362987367","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGWS200804004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764929092","display_name":"Zhongguo weishengtaixue zazhi","issn_l":"1005-376X","issn":["1005-376X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800792","host_organization_name":"Dalian University of Technology","host_organization_lineage":["https://openalex.org/P4320800792"],"host_organization_lineage_names":["Dalian University of Technology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo weishengtaixue zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085813794","display_name":"Lu-Quan Li","orcid":"https://orcid.org/0000-0002-5496-6578","observed_orcids":["https://orcid.org/0000-0002-5496-6578","https://orcid.org/0009-0002-9468-1988"]},"institutions":[{"id":"https://openalex.org/I4210159428","display_name":"Children's Hospital of Chongqing Medical University","ror":"https://ror.org/05pz4ws32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159428"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lu-Quan Li","raw_affiliation_strings":["Children\u2019s Hospital of Chongqing Medical University,Chongqing 400014,China)"],"raw_orcid":"https://orcid.org/0000-0002-5496-6578","affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital of Chongqing Medical University,Chongqing 400014,China)","institution_ids":["https://openalex.org/I4210159428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085813794"],"corresponding_institution_ids":["https://openalex.org/I4210159428"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21847563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bacterial-biofilms","display_name":"bacterial biofilms","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alginate","display_name":"alginate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/phagocytosis-resistance","display_name":"phagocytosis resistance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/macrophage-depletion","display_name":"macrophage depletion","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.9647244215011597},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.8690417408943176},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.7975223064422607},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.681570291519165},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.6000458002090454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5176037549972534},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3539525270462036},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32725077867507935},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2865385413169861},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10918951034545898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2362987367","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGWS200804004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764929092","display_name":"Zhongguo weishengtaixue zazhi","issn_l":"1005-376X","issn":["1005-376X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800792","host_organization_name":"Dalian University of Technology","host_organization_lineage":["https://openalex.org/P4320800792"],"host_organization_lineage_names":["Dalian University of Technology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo weishengtaixue zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W142501559","https://openalex.org/W2331026343","https://openalex.org/W4324378621","https://openalex.org/W2168241903","https://openalex.org/W2163803918","https://openalex.org/W130803810","https://openalex.org/W1901233028","https://openalex.org/W4256017579","https://openalex.org/W2014750820","https://openalex.org/W2437493642"],"abstract_inverted_index":{"Objective":[0],"To":[1],"explore":[2,33],"the":[3,34,50,73,88,95,108,118,125,138,141,150,155,162,175,179,192,199],"influence":[4,35],"of":[5,21,36,56,143,157,168,185,201,214,220],"Pseudomonas":[6],"aeruginosa(PA)":[7],"biofilm":[8,19,37,84,97,203],"and":[9,29,45,147],"alginate":[10,48,114,126,144,221],"on":[11,38],"macrophage":[12,40,104,134,158,169,186,206,210,223],"phagocytosis":[13,51,58,80,105,111,135,211],"function":[14],"in":[15,68,82,113],"mouse.Methods":[16],"The":[17,65],"bacterial":[18,66],"suspension":[20],"PA":[22,83,96],"was":[23,41,53,59],"used":[24],"to":[25,32,72,87,103,107,117,133,137,174,191],"infect":[26],"macrophage-depleted":[27,69],"mouse":[28,31,44,70],"control":[30,74,89,109,119,139],"macrophage.The":[39],"isolated":[42],"from":[43],"added":[46],"with":[47],"inside,then":[49],"rate":[52,81,112],"determined.The":[54],"capability":[55,156,167,184],"macrophage's":[57],"detected":[60],"by":[61],"neutral":[62,160,171,188],"red":[63,172,189],"method.Results":[64],"count":[67],"compared":[71,86,106,116,136],"group":[75,85,90,98,115,120,127],"was(4.16\u00b13.36)\u00d7105":[76],"/ml":[77],"to(5.15\u00b11.92)\u00d7105":[78],"/ml,t=0.7211,P=0.483.The":[79],"was(13.82\u00b14.71)%":[91],"to(42.73\u00b111.00)%,Q=12.3231,P0.01.This":[92],"suggested":[93],"that":[94,124],"can":[99,128,197,204,208],"be":[100,130],"more":[101,131],"resistant":[102,132],"group.The":[110],"was(22.91\u00b16.20)%":[121],"to(42.73\u00b111.00)%,Q=8.4465,P0.05.This":[122],"showed":[123],"also":[129],"group.When":[140],"concentration":[142,164,181],"were":[145],"0,25,50,75,100,125":[146],"150":[148],"\u03bcg/ml":[149,177,194,216],"absorbance":[151],"A(540":[152],"nm)which":[153],"represents":[154],"phagocytosing":[159,170,187],"red,were(0.271\u00b10.044),(0.456\u00b10.062),(0.445\u00b10.061),(0.551\u00b10.065),(0.210\u00b10.053),(0.186\u00b10.026)and(0.195\u00b10.025)respectively.When":[161],"alginate's":[163,180],"\u226475":[165,215],"\u03bcg/ml,the":[166,183],"strengthened(P0.05),compared":[173],"0":[176,193],"group;When":[178],"75":[182],"decreased(P0.05),compared":[190],"group.Conclusion":[195],"Macrophage":[196],"prevent":[198],"invasion":[200],"PA.PA":[202],"inhibit":[205,222],"phagocytosis.Alginate":[207],"promote":[209],"at":[212],"doses":[213,219],"while":[217],"larger":[218],"phagocytosis.":[224]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}