{"id":"https://openalex.org/W2362867485","doi":null,"title":"Dopamine receptor gene polymorphisms in Guangzhou Hans.","display_name":"Dopamine receptor gene polymorphisms in Guangzhou Hans.","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W2362867485","mag":"2362867485","pmid":"https://pubmed.ncbi.nlm.nih.gov/11024217"},"language":"zh","primary_location":{"id":"pmid:11024217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11024217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics","raw_type":"English Abstract"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Wang","raw_affiliation_strings":["Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, 510080 P.R.China. jian-w@163.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, the First Affiliated Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou, 510080 P.R.China. jian-w@163.net","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051221671","display_name":"Zhong Liu","orcid":"https://orcid.org/0000-0001-8173-9656","observed_orcids":["https://orcid.org/0000-0001-8173-9656","https://orcid.org/0009-0005-7945-2468","https://orcid.org/0000-0001-5582-0960"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z Liu","raw_affiliation_strings":["Sun-Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun-Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090743896","display_name":"Brianna Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B Chen","raw_affiliation_strings":["Sun-Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun-Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402504","display_name":"Jian Li","orcid":"https://orcid.org/0000-0002-4549-0694","observed_orcids":["https://orcid.org/0000-0002-4549-0694"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Li","raw_affiliation_strings":["Sun-Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun-Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Pan","raw_affiliation_strings":["Sun-Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun-Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106524710","display_name":"Lu X","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X Lu","raw_affiliation_strings":["Sun-Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun-Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":null,"display_name":"Y Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Zhu","raw_affiliation_strings":["Sun-Yat-Sen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun-Yat-Sen University","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.1795479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"5","first_page":"348","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8978999853134155,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0763000026345253,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-receptor-genes","display_name":"dopamine receptor genes","score":0.7549999952316284},{"id":"https://openalex.org/keywords/drd2","display_name":"DRD2","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dopamine-d3-receptor","display_name":"dopamine D3 receptor","score":1.0},{"id":"https://openalex.org/keywords/drd5","display_name":"DRD5","score":1.0},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9010000228881836},{"id":"https://openalex.org/keywords/allele-and-genotype-frequencies","display_name":"genotype and allele frequencies","score":0.7639999985694885},{"id":"https://openalex.org/keywords/han-chinese","display_name":"Han Chinese","score":0.6909999847412109},{"id":"https://openalex.org/keywords/guangzhou","display_name":"Guangzhou","score":0.5870000123977661},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.460999995470047},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hardy-weinberg-equilibrium","display_name":"Hardy-Weinberg equilibrium","score":0.9290000200271606},{"id":"https://openalex.org/keywords/3-noncoding-region","display_name":"3' non-coding region","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2779105492","wikidata":"https://www.wikidata.org/wiki/Q4385680","display_name":"TaqI","level":5,"score":0.787746787071228},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.7363054156303406},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6318215131759644},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5801090598106384},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5755717158317566},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.5429292917251587},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5352213382720947},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5126542448997498},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5116584897041321},{"id":"https://openalex.org/C175239580","wikidata":"https://www.wikidata.org/wiki/Q656595","display_name":"Genotype frequency","level":5,"score":0.5013391971588135},{"id":"https://openalex.org/C100882016","wikidata":"https://www.wikidata.org/wiki/Q49974","display_name":"Hardy\u2013Weinberg principle","level":5,"score":0.5004136562347412},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.452440470457077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43129926919937134},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.4100153148174286},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.2089788317680359}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11024217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11024217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics","raw_type":"English Abstract"},{"id":"mag:2362867485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11024217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2350614060","https://openalex.org/W2348576383","https://openalex.org/W2372854935","https://openalex.org/W2360355135","https://openalex.org/W2370177856","https://openalex.org/W2254211481","https://openalex.org/W2361965628","https://openalex.org/W4412379176","https://openalex.org/W2402227962","https://openalex.org/W2372055200"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"determine":[2],"the":[3,30,52,60,64,67,75,81,85,100,122,128,134,152,174,180,186,204,229,243,249,268],"distribution":[4],"of":[5,22,32,42,66,74,84,99,121,127,137,151,173,179,189,203,242,248,253,267,290],"dopamine":[6],"D2,":[7],"D3,":[8],"and":[9,40,70,93,103,112,124,145,155,164,176,197,207,216,232,245,261,271,280,300],"D5":[10],"receptor(DRD2,":[11],"DRD3,":[12,292],"DRD5)":[13],"gene":[14,87,139,191,255,294],"polymorphisms":[15,289],"in":[16,80,133,185,236,295,304],"Guangzhou":[17,25,237,296],"Hans.":[18],"METHODS:":[19],"A":[20,77],"total":[21],"141":[23,61],"healthy":[24],"Hans":[26,297],"were":[27,49,88,106,140,158,192,210,256,274,298],"studied":[28],"by":[29],"use":[31],"polymerase":[33],"chain":[34],"reaction-restriction":[35],"fragment":[36],"length":[37],"polymorphism":[38,235],"(PCR-RFLP)":[39],"PCR-amplification":[41],"specific":[43],"allele":[44],"(PASA)":[45],"techniques.":[46],"Current":[47],"results":[48],"compared":[50],"with":[51],"data":[53],"on":[54],"other":[55,305],"ethnic":[56],"groups.":[57],"RESULTS:":[58],"Within":[59],"individuals":[62],"tested,":[63],"frequencies":[65,98,120,150,172,202,241,266],"A1(Taq":[68],"I-)":[69],"A2(Taq":[71],"I+)":[72],"alleles":[73,126,178,247],"TaqI":[76],"mutation":[78,131,183,251],"site":[79,132,184,252],"3'non-coding":[82],"region":[83],"DRD2":[86],"found":[89,107,141,159,193,211,257,275],"to":[90,108,142,160,194,212,258,276],"be":[91,109,143,161,195,213,259,277],"48%":[92],"52%,":[94],"respectively.":[95,147,199,263],"The":[96,119,148,171,200,240,264,288],"observed":[97,149,201,227,265],"A1A1,":[101,153],"A1A2":[102,154],"A2A2":[104,156],"genotypes":[105,157,209,273],"17%,":[110],"52%":[111],"31%,":[113],"respectively,":[114,166,218,282],"which":[115,167,219,283],"met":[116,168,220,284],"Hardy-Weinberg":[117,169,221,285],"equilibrium.":[118,170,222,286],"A1":[123],"A2":[125],"Bal":[129,230],"I":[130,182,231,234],"exon":[135],"1":[136,175],"DRD3":[138,190],"73%":[144],"27%,":[146],"53%,":[162],"39%":[163],"8%,":[165],"2":[177],"Msp":[181,233],"intron":[187],"5":[188],"62.5%":[196],"37.5%,":[198],"1-1,":[205],"1-2":[206],"2-2":[208],"35%,":[214],"55%":[215],"10%,":[217],"No":[223],"linkage":[224],"disequilibrium":[225],"was":[226],"between":[228],"Hans(chi(2)=0165,":[238],"P>0.05).":[239],"T":[244],"C":[246],"T978C":[250],"DRD5":[254,293],"51%":[260],"49%,":[262],"T/T,":[269],"T/C":[270],"C/C":[272],"23.6%,":[278],"54.6%":[279],"21.8%,":[281],"CONCLUSION:":[287],"DRD2,":[291],"high":[299],"different":[301],"from":[302],"those":[303],"populations.":[306]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}