{"id":"https://openalex.org/W236242590","doi":"https://doi.org/10.2174/1386207302666220126182805","title":"Phage Displayed Peptide Libraries","display_name":"Phage Displayed Peptide Libraries","publication_year":1999,"publication_date":"1999-02-01","ids":{"openalex":"https://openalex.org/W236242590","doi":"https://doi.org/10.2174/1386207302666220126182805","mag":"236242590","pmid":"https://pubmed.ncbi.nlm.nih.gov/10420971"},"language":"en","primary_location":{"id":"doi:10.2174/1386207302666220126182805","doi":"https://doi.org/10.2174/1386207302666220126182805","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207302666220126182805","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry & High Throughput Screening","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029338279","display_name":"Gianni Cesareni","orcid":"https://orcid.org/0000-0002-9528-6018","observed_orcids":["https://orcid.org/0000-0002-9528-6018"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianni Cesareni","raw_affiliation_strings":["Department  of Biology, Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","Department of Biology, Enrico Calef, University of Rome Tor Vergata, Italy. cesareni@uniroma2.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department  of Biology, Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biology, Enrico Calef, University of Rome Tor Vergata, Italy. cesareni@uniroma2.it","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018540028","display_name":"Luisa Castagnoli","orcid":"https://orcid.org/0000-0001-5283-8671","observed_orcids":["https://orcid.org/0000-0001-5283-8671"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luisa Castagnoli","raw_affiliation_strings":["Department  of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","Department of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department  of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107494926","display_name":"Gianluca Cestra","orcid":"https://orcid.org/0000-0002-6322-631X","observed_orcids":["https://orcid.org/0000-0002-6322-631X"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Cestra","raw_affiliation_strings":["Department  of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","Department of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department  of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"Department of Biology: Enrico Calef, University of Rome Tor Vergata, Rome 00133, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029338279"],"corresponding_institution_ids":["https://openalex.org/I116067653"],"apc_list":null,"apc_paid":null,"fwci":1.3064,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.7806264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"2","issue":"1","first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.04989999905228615,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.9940000176429749},{"id":"https://openalex.org/keywords/peptide-libraries","display_name":"peptide libraries","score":0.9860000014305115},{"id":"https://openalex.org/keywords/protein-display","display_name":"protein display","score":0.48100000619888306},{"id":"https://openalex.org/keywords/library-construction","display_name":"library construction","score":0.4000000059604645},{"id":"https://openalex.org/keywords/library-screening","display_name":"library screening","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6264920234680176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5675251483917236},{"id":"https://openalex.org/C2776471321","wikidata":"https://www.wikidata.org/wiki/Q7166526","display_name":"Peptide library","level":4,"score":0.5209276080131531},{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.5068021416664124},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4909225106239319},{"id":"https://openalex.org/C13575015","wikidata":"https://www.wikidata.org/wiki/Q1562492","display_name":"Genomic library","level":4,"score":0.46412232518196106},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.46313977241516113},{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.43151915073394775},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.41633540391921997},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35576725006103516},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3388565182685852},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.32516637444496155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1294628083705902}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019151","descriptor_name":"Peptide Library","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1386207302666220126182805","doi":"https://doi.org/10.2174/1386207302666220126182805","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1386207302666220126182805","pdf_url":null,"source":{"id":"https://openalex.org/S50933791","display_name":"Combinatorial Chemistry & High Throughput Screening","issn_l":"1386-2073","issn":["1386-2073","1875-5402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial Chemistry & High Throughput Screening","raw_type":"journal-article"},{"id":"pmid:10420971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10420971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Combinatorial chemistry & high throughput screening","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046319392","https://openalex.org/W2380579232","https://openalex.org/W1977090192","https://openalex.org/W2361653534","https://openalex.org/W3017320541","https://openalex.org/W2359941614","https://openalex.org/W2066892610","https://openalex.org/W2515405317","https://openalex.org/W2066035545","https://openalex.org/W2254535559"],"abstract_inverted_index":{"Peptide":[0],"libraries":[1,138],"may":[2,82],"be":[3,46,79,83],"constructed":[4],"by":[5,85],"grafting,":[6],"in":[7,53,115],"vitro,":[8],"random":[9,76],"DNA":[10],"sequences":[11],"into":[12,24],"a":[13,73,86,108,111],"carrier":[14],"gene":[15,121],"and":[16,48,66,126,134,144,152],"then":[17],"introducing":[18],"the":[19,37,71,99,116,119,132,148],"degenerate":[20],"hybrid":[21],"coding":[22,104],"sequence":[23],"an":[25],"expression":[26,39,44],"organism.":[27],"This":[28,128],"review":[29,129],"will":[30],"focus":[31],"on":[32,131,140],"phage":[33,69,142],"display,":[34],"which":[35,49],"was":[36],"first":[38],"organism":[40],"for":[41,107],"peptide":[42,100,113,137],"library":[43,101],"to":[45],"described":[47],"still":[50],"maintains":[51],"predominance":[52],"this":[54],"area":[55],"because":[56],"of":[57,63,75,88,98,110,118,136,150],"its":[58,103,124],"simplicity,":[59],"minimal":[60],"cost,":[61],"ease":[62],"manipulation,":[64],"power":[65],"robustness.":[67],"Using":[68],"as":[70],"host,":[72],"repertoire":[74],"peptides":[77],"can":[78],"expressed":[80],"that":[81],"searched":[84],"variety":[87],"screening":[89,135],"or":[90],"selection":[91,106],"procedures.":[92],"By":[93],"physically":[94],"associating":[95],"each":[96],"element":[97],"with":[102],"sequence,":[105],"property":[109],"specific":[112],"results":[114],"enrichment":[117],"corresponding":[120],"thus":[122],"facilitating":[123],"cloning":[125],"amplification.":[127],"focuses":[130],"construction":[133],"displayed":[139],"filamentous":[141],"capsid":[143],"only":[145],"briefly":[146],"discusses":[147],"display":[149],"proteins":[151],"protein":[153],"domains.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}