{"id":"https://openalex.org/W23616601","doi":"https://doi.org/10.1186/2045-7022-3-s3-p80","title":"Using human-severe combined immunodeficiency (hu-SCID) mice as a model for testing allergenicity of genetically modified organisms (GMOs)","display_name":"Using human-severe combined immunodeficiency (hu-SCID) mice as a model for testing allergenicity of genetically modified organisms (GMOs)","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W23616601","doi":"https://doi.org/10.1186/2045-7022-3-s3-p80","mag":"23616601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3723968"},"language":"en","primary_location":{"id":"doi:10.1186/2045-7022-3-s3-p80","doi":"https://doi.org/10.1186/2045-7022-3-s3-p80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-7022-3-s3-p80","pdf_url":"https://link.springer.com/content/pdf/10.1186/2045-7022-3-S3-P80.pdf","source":{"id":"https://openalex.org/S2756291293","display_name":"Clinical and Translational Allergy","issn_l":"2045-7022","issn":["2045-7022"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Allergy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/2045-7022-3-S3-P80.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036600887","display_name":"R Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"R Lee","raw_affiliation_strings":["Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Department of Dermatology, Medical University, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Department of Dermatology, Medical University, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049065129","display_name":"David S. Reiner","orcid":"https://orcid.org/0000-0002-8289-7311","observed_orcids":["https://orcid.org/0000-0002-8289-7311"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"D Reiner","raw_affiliation_strings":["Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Department of Dermatology, Medical University, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Department of Dermatology, Medical University, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070698745","display_name":"Anita Macz\u00f3","orcid":"https://orcid.org/0000-0002-0284-6670","observed_orcids":["https://orcid.org/0000-0002-0284-6670"]},"institutions":[{"id":"https://openalex.org/I4210167173","display_name":"Central Environmental and Food Science Research Institute","ror":"https://ror.org/05x923c26","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210167173"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"A Macz\u00f3","raw_affiliation_strings":["Unit of Biology, Central Food Research Institute, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Biology, Central Food Research Institute, Budapest, Hungary","institution_ids":["https://openalex.org/I4210167173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069835229","display_name":"Noemi Bakos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167173","display_name":"Central Environmental and Food Science Research Institute","ror":"https://ror.org/05x923c26","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210167173"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"N Bakos","raw_affiliation_strings":["Unit of Biology, Central Food Research Institute, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Biology, Central Food Research Institute, Budapest, Hungary","institution_ids":["https://openalex.org/I4210167173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091355929","display_name":"\u00c9. Gelencs\u00e9r","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167173","display_name":"Central Environmental and Food Science Research Institute","ror":"https://ror.org/05x923c26","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210167173"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"\u00c9 Gelencs\u00e9r","raw_affiliation_strings":["Unit of Biology, Central Food Research Institute, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Biology, Central Food Research Institute, Budapest, Hungary","institution_ids":["https://openalex.org/I4210167173"]}]},{"author_position":"middle","author":{"id":null,"display_name":"TJV Higgins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I4210152679","display_name":"Plant Industry","ror":"https://ror.org/05jg9pj51","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4210152679","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"TJV Higgins","raw_affiliation_strings":["Plant Industry, Commonwealth Scientific and Industrial Research Organization, Canberra, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Industry, Commonwealth Scientific and Industrial Research Organization, Canberra, Australia","institution_ids":["https://openalex.org/I1292875679","https://openalex.org/I4210152679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089633144","display_name":"MM Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"MM Epstein","raw_affiliation_strings":["Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Department of Dermatology, Medical University, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology, Allergy and Infectious Diseases, Experimental Allergy, Department of Dermatology, Medical University, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5036600887"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":0.2653,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61389776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"S3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11426","display_name":"Genetically Modified Organisms Research","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergenicity-testing","display_name":"allergenicity testing","score":0.7509999871253967},{"id":"https://openalex.org/keywords/genetically-modified-organisms","display_name":"genetically modified organisms","score":0.9549999833106995},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.8510000109672546},{"id":"https://openalex.org/keywords/alpha-amylase-inhibitors","display_name":"alpha-amylase inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/food-allergy","display_name":"food allergy","score":0.781000018119812},{"id":"https://openalex.org/keywords/ige-sensitization","display_name":"IgE sensitization","score":0.8130000233650208},{"id":"https://openalex.org/keywords/allergic-lung-inflammation","display_name":"allergic lung inflammation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mucus-hypersecretion","display_name":"mucus hypersecretion","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6961560249328613},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6879445314407349},{"id":"https://openalex.org/C2779468541","wikidata":"https://www.wikidata.org/wiki/Q1334408","display_name":"Severe combined immunodeficiency","level":3,"score":0.6347761154174805},{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.5904766321182251},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.5729094743728638},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.5492076277732849},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.5044804811477661},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4897329807281494},{"id":"https://openalex.org/C51456166","wikidata":"https://www.wikidata.org/wiki/Q182726","display_name":"Genetically modified organism","level":3,"score":0.47840771079063416},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4564320147037506},{"id":"https://openalex.org/C2776027960","wikidata":"https://www.wikidata.org/wiki/Q769815","display_name":"Food allergy","level":3,"score":0.4325897693634033},{"id":"https://openalex.org/C2779675166","wikidata":"https://www.wikidata.org/wiki/Q4732119","display_name":"Allergic inflammation","level":3,"score":0.43169790506362915},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4256618916988373},{"id":"https://openalex.org/C2776953665","wikidata":"https://www.wikidata.org/wiki/Q4732121","display_name":"Allergic response","level":4,"score":0.425215482711792},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4124157726764679},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4097389876842499},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2396489977836609},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1401596963405609},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.10523450374603271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/2045-7022-3-s3-p80","doi":"https://doi.org/10.1186/2045-7022-3-s3-p80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-7022-3-s3-p80","pdf_url":"https://link.springer.com/content/pdf/10.1186/2045-7022-3-S3-P80.pdf","source":{"id":"https://openalex.org/S2756291293","display_name":"Clinical and Translational Allergy","issn_l":"2045-7022","issn":["2045-7022"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Allergy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2717098","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3723968","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3723968","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3723968/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Allergy","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/2045-7022-3-s3-p80","doi":"https://doi.org/10.1186/2045-7022-3-s3-p80","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-7022-3-s3-p80","pdf_url":"https://link.springer.com/content/pdf/10.1186/2045-7022-3-S3-P80.pdf","source":{"id":"https://openalex.org/S2756291293","display_name":"Clinical and Translational Allergy","issn_l":"2045-7022","issn":["2045-7022"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Allergy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W23616601.pdf","grobid_xml":"https://content.openalex.org/works/W23616601.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1509579701","https://openalex.org/W2071442646","https://openalex.org/W2079710948","https://openalex.org/W2554110321","https://openalex.org/W2154838556","https://openalex.org/W2378396421","https://openalex.org/W2167771194","https://openalex.org/W6926438845","https://openalex.org/W3214491972","https://openalex.org/W2271920112"],"abstract_inverted_index":{"GM":[0,32,86],"peas":[1],"expressing":[2],"the":[3,35,105,133,142,181,220,232],"alpha-amylase":[4],"inhibitor":[5],"(AAI)":[6],"protein":[7,108],"derived":[8,149,186],"from":[9,64,150,187],"common":[10],"Tendergreen":[11,91],"bean":[12,92],"were":[13,77,100,130,177,202,213],"created":[14],"to":[15,48,54,205,215,228,234,242],"protect":[16],"them":[17],"against":[18],"infestation":[19],"by":[20,57],"pea":[21,89],"weevils.":[22],"Although":[23],"animal":[24],"models":[25],"are":[26],"used":[27],"for":[28,82,116,171],"studying":[29],"allergenicity":[30],"of":[31,104,135],"containing":[33],"foods,":[34],"correlation":[36],"with":[37,85,138,240],"human":[38],"allergy":[39,237],"remains":[40],"controversial.":[41],"Our":[42],"aim":[43],"in":[44,118,132,180,219,238],"this":[45],"study":[46,55],"was":[47],"establish":[49],"a":[50,113],"humanized":[51,221],"mouse":[52],"model":[53,224],"GMOs":[56],"adoptively":[58],"transferring":[59],"peripheral":[60],"blood":[61],"mononuclear":[62],"cells":[63,212],"AAI-specific":[65],"IgE-positive":[66],"legume":[67],"allergic":[68,120,151,157,172,188],"and":[69,90,152,160,189,207],"non-allergic":[70,153,190],"individuals":[71,239],"into":[72],"SCID":[73],"mice.":[74,222],"These":[75],"mice":[76,99,136,148,185],"then":[78],"gavaged":[79],"twice":[80],"weekly":[81],"1":[83,102],"month":[84],"pea,":[87],"non-transgenic":[88,143],"seed":[93,167],"meal":[94,168],"suspensions":[95],"or":[96,109,127,140],"PBS.":[97],"Subsequently,":[98],"administered":[101],"dose":[103],"purified":[106],"AAI":[107,206,216],"PBS":[110,139],"intranasally":[111],"as":[112],"read":[114],"out":[115],"an":[117],"vivo":[119],"response.":[121],"Seventy-two":[122],"hours":[123],"later,":[124],"no":[125,178],"eosinophilia":[126],"mucus":[128,161],"hypersecretion":[129],"observed":[131],"lungs":[134],"treated":[137],"fed":[141],"peas.":[144],"In":[145],"contrast,":[146],"hu-SCID":[147,184],"donors":[154,194],"had":[155,195],"intense":[156],"lung":[158],"inflammation":[159],"over":[162],"production":[163],"illustrating":[164],"that":[165,200],"AAI-containing":[166],"feeding":[169,218],"primed":[170],"immune":[173],"responses.":[174],"However,":[175],"there":[176],"differences":[179],"responses":[182],"between":[183],"donors.":[191],"Because":[192],"both":[193,203],"anti-AAI":[196],"antibodies,":[197],"we":[198],"hypothesize":[199],"they":[201],"sensitized":[204],"thus":[208],"indistinguishable":[209],"when":[210],"their":[211],"exposed":[214],"during":[217],"This":[223],"provides":[225],"new":[226],"opportunities":[227],"investigate":[229],"factors":[230],"underlying":[231],"propensity":[233],"develop":[235],"food":[236,243],"antibodies":[241],"allergens.":[244]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}