{"id":"https://openalex.org/W236161958","doi":"https://doi.org/10.1007/s10269-014-2445-4","title":"Bioth\u00e9rapies par voie sous-cutan\u00e9e : modalit\u00e9s d\u2019absorption et implications cliniques","display_name":"Bioth\u00e9rapies par voie sous-cutan\u00e9e : modalit\u00e9s d\u2019absorption et implications cliniques","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W236161958","doi":"https://doi.org/10.1007/s10269-014-2445-4","mag":"236161958"},"language":"fr","primary_location":{"id":"doi:10.1007/s10269-014-2445-4","doi":"https://doi.org/10.1007/s10269-014-2445-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10269-014-2445-4","pdf_url":null,"source":{"id":"https://openalex.org/S170348691","display_name":"ONCOLOGIE","issn_l":"1292-3818","issn":["1292-3818","1765-2839"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110411354","display_name":"Fr\u00e9d\u00e9ric Pinguet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154388","display_name":"Institut Regional du Cancer de Montpellier","ror":"https://ror.org/02693j602","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210141925","https://openalex.org/I4387154388"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"F. Pinguet","raw_affiliation_strings":["Service pharmacie-oncopharmacologie, Institut r\u00e9gional du cancer de Montpellier (ICM), Val d\u2019Aurelle, F-34298, Montpellier cedex 05, France","Institut r\u00e9gional du Cancer de Montpellier (ICM)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service pharmacie-oncopharmacologie, Institut r\u00e9gional du cancer de Montpellier (ICM), Val d\u2019Aurelle, F-34298, Montpellier cedex 05, France","institution_ids":["https://openalex.org/I4387154388"]},{"raw_affiliation_string":"Institut r\u00e9gional du Cancer de Montpellier (ICM)","institution_ids":["https://openalex.org/I4387154388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090050048","display_name":"Gerard Alain Milano","orcid":"https://orcid.org/0000-0003-2478-0040","observed_orcids":["https://orcid.org/0000-0003-2478-0040"]},"institutions":[{"id":"https://openalex.org/I4210151846","display_name":"Centre Antoine Lacassagne","ror":"https://ror.org/05hmfw828","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210151846"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"G. Milano","raw_affiliation_strings":["Laboratoire d\u2019oncopharmacologie, centre Antoine-Lacassagne, F-06189, Nice, France","centre Antoine-Lacassagne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u2019oncopharmacologie, centre Antoine-Lacassagne, F-06189, Nice, France","institution_ids":["https://openalex.org/I4210151846"]},{"raw_affiliation_string":"centre Antoine-Lacassagne","institution_ids":["https://openalex.org/I4210151846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090050048","https://openalex.org/A5110411354"],"corresponding_institution_ids":["https://openalex.org/I4210151846","https://openalex.org/I4387154388"],"apc_list":{"value":1000,"currency":"EUR","value_usd":1130},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"7-8","first_page":"393","last_page":"400"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.3628000020980835,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.14480000734329224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12255","display_name":"Biosimilars and Bioanalytical Methods","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.8299999833106995},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7300000190734863},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7519999742507935},{"id":"https://openalex.org/keywords/fixed-dose-regimen","display_name":"fixed-dose regimen","score":0.5879999995231628},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.871999979019165},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.5709999799728394},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6578919887542725},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6054345965385437}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s10269-014-2445-4","doi":"https://doi.org/10.1007/s10269-014-2445-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10269-014-2445-4","pdf_url":null,"source":{"id":"https://openalex.org/S170348691","display_name":"ONCOLOGIE","issn_l":"1292-3818","issn":["1292-3818","1765-2839"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncologie","raw_type":"journal-article"},{"id":"mag:3048062608","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007%2Fs10269-014-2445-4.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W28215347","https://openalex.org/W184799612","https://openalex.org/W206059586","https://openalex.org/W1586699825","https://openalex.org/W1648925388","https://openalex.org/W1906683030","https://openalex.org/W1970875728","https://openalex.org/W1978261191","https://openalex.org/W1993519240","https://openalex.org/W2005475183","https://openalex.org/W2015186160","https://openalex.org/W2016569715","https://openalex.org/W2018796671","https://openalex.org/W2024903800","https://openalex.org/W2028068697","https://openalex.org/W2030670140","https://openalex.org/W2044749789","https://openalex.org/W2046752196","https://openalex.org/W2066751846","https://openalex.org/W2067488225","https://openalex.org/W2067933166","https://openalex.org/W2087619860","https://openalex.org/W2107103026","https://openalex.org/W2112163451","https://openalex.org/W2158548553","https://openalex.org/W4205407880"],"related_works":["https://openalex.org/W3048062608","https://openalex.org/W4390671366","https://openalex.org/W7152046422","https://openalex.org/W7214246933","https://openalex.org/W2101680192","https://openalex.org/W4399654086","https://openalex.org/W7214701311","https://openalex.org/W2018796671","https://openalex.org/W1643052695","https://openalex.org/W4402555259"],"abstract_inverted_index":{"L\u2019utilisation":[0],"de":[1,14,17,31,44,65,88,92,110,129,178,204,218,236,246],"la":[2,15,46,55,63,68,103,143,179,191,219,241],"voie":[3,33,90,170,180,192,207],"sous-cutan\u00e9e":[4],"(SC)":[5],"pour":[6,142],"l\u2019administration":[7],"des":[8,19,25,57,70,99,145],"m\u00e9dicaments":[9],"injectables":[10],"permet":[11],"une":[12,52,72,121,201,212],"am\u00e9lioration":[13],"qualit\u00e9":[16],"vie":[18],"patients":[20],"et":[21,221,245],"facilite":[22],"le":[23,82,114,216],"d\u00e9veloppement":[24,98],"alternatives":[26],"\u00e0":[27,38,54,91,108,190,211],"l\u2019hospitalisation.":[28],"Cependant,":[29,128],"l\u2019utilisation":[30,87],"cette":[32,89,149],"a":[34,76,84],"longtemps":[35],"\u00e9t\u00e9":[36,77],"limit\u00e9e":[37],"certaines":[39],"mol\u00e9cules,":[40,71],"car":[41],"elle":[42],"n\u00e9cessite":[43],"franchir":[45],"matrice":[47],"extracellulaire":[48],"(MEC)":[49],"qui":[50],"est":[51,138],"barri\u00e8re":[53],"diffusion":[56,69],"fluides":[58],"dans":[59],"l\u2019espace":[60],"SC.":[61],"Apr\u00e8s":[62],"d\u00e9couverte":[64],"l\u2019hyaluronidase":[66],"am\u00e9liorant":[67],"version":[73],"recombinante":[74],"(rHuPH20)":[75],"d\u00e9velopp\u00e9e.":[78],"Associ\u00e9":[79],"au":[80,126,186],"m\u00e9dicament,":[81],"rHuPH20":[83,187],"permis":[85],"d\u2019\u00e9largir":[86],"plus":[93,140],"grosses":[94],"mol\u00e9cules.":[95],"Lors":[96],"du":[97,116,124,154,159,161,183,195],"anticorps":[100,146],"monoclonaux":[101],"anticanc\u00e9reux,":[102],"posologie":[104],"\u00e9tait":[105],"initialement":[106],"adapt\u00e9e":[107,214],"partir":[109],"crit\u00e8res":[111],"tels":[112],"que":[113],"poids":[115,217],"patient,":[117],"permettant,":[118],"en":[119,223,232],"th\u00e9orie,":[120],"meilleure":[122],"exposition":[123],"patient":[125],"m\u00e9dicament.":[127],"nombreux":[130],"auteurs":[131],"rapportent":[132],"qu\u2019une":[133],"administration":[134],"par":[135,169,188,206],"dose":[136,202,213],"fixe":[137,203],"globalement":[139],"pertinente":[141],"majorit\u00e9":[144],"monoclonaux.":[147],"Dans":[148],"revue,":[150],"nous":[151],"d\u00e9taillons":[152],"l\u2019exemple":[153],"trastuzumab":[155,205],"(Herceptin\u00ae),":[156],"traitement":[157],"standard":[158],"cancer":[160],"sein":[162],"HER2":[163],"amplifi\u00e9":[164],"ou":[165],"surexprim\u00e9,":[166],"habituellement":[167],"administr\u00e9":[168],"intraveineuse":[171],"(IV).":[172],"Plusieurs":[173],"travaux":[174,198],"ont":[175,199],"\u00e9valu\u00e9":[176],"l\u2019int\u00e9r\u00eat":[177],"SC":[181,208],"(poids":[182,194],"patient)":[184],"associ\u00e9e":[185],"rapport":[189],"IV":[193],"patient).":[196],"D\u2019autres":[197],"compar\u00e9":[200],"(+":[209],"rHuPH20)":[210],"selon":[215],"patiente":[220],"inject\u00e9e":[222],"IV.":[224],"Globalement,":[225],"les":[226],"diff\u00e9rentes":[227],"modalit\u00e9s":[228],"d\u2019administration":[229],"semblent":[230],"\u00e9quivalentes":[231],"termes":[233],"d\u2019efficacit\u00e9":[234],"(n\u00e9oadjuvant),":[235],"pharmacocin\u00e9tique":[237],"(PK)":[238],"[aire":[239],"sous":[240],"courbe,":[242],"concentration":[243],"r\u00e9siduelle]":[244],"toxicit\u00e9.":[247]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}