{"id":"https://openalex.org/W2361600841","doi":null,"title":"Clinical significance of nitric oxide synthase mRNA expression in patients with congenital heart disease associated with pulmonary hypertension","display_name":"Clinical significance of nitric oxide synthase mRNA expression in patients with congenital heart disease associated with pulmonary hypertension","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2361600841","mag":"2361600841"},"language":"en","primary_location":{"id":"mag:2361600841","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-DSJY200614023.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764924667","display_name":"Di-Si Junyi Daxue xuebao","issn_l":"1000-2790","issn":["1000-2790"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322632808","host_organization_name":"Fourth Military University","host_organization_lineage":["https://openalex.org/P4322632808"],"host_organization_lineage_names":["Fourth Military University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-Si Junyi Daxue xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040799766","display_name":"Feng Jia","orcid":"https://orcid.org/0000-0001-6357-9644","observed_orcids":["https://orcid.org/0000-0001-6357-9644"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Feng Jia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6357-9644","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040799766"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36760207,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.984000027179718},{"id":"https://openalex.org/keywords/congenital-heart-disease","display_name":"congenital heart disease","score":0.8989999890327454},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pulmonary-arteriopathy","display_name":"pulmonary arteriopathy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nos-mrna-expression","display_name":"NOS mRNA expression","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lung-tissue","display_name":"lung tissue","score":0.7570000290870667},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.9437083601951599},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7038304209709167},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6347308158874512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.585835337638855},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5578596591949463},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.516133189201355},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.48806893825531006},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.43708565831184387},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.42781805992126465},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4127275347709656},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.41050979495048523}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2361600841","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-DSJY200614023.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764924667","display_name":"Di-Si Junyi Daxue xuebao","issn_l":"1000-2790","issn":["1000-2790"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322632808","host_organization_name":"Fourth Military University","host_organization_lineage":["https://openalex.org/P4322632808"],"host_organization_lineage_names":["Fourth Military University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Di-Si Junyi Daxue xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096399399","https://openalex.org/W2378223183","https://openalex.org/W2183520272","https://openalex.org/W2362438513","https://openalex.org/W3030765233","https://openalex.org/W2035111611","https://openalex.org/W2140639869","https://openalex.org/W2149156922","https://openalex.org/W1971410288","https://openalex.org/W1984481499"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"explore":[2],"the":[3,68,82,98,104,108,139,147],"pathophysiological":[4],"significance":[5],"of":[6,135,149],"nitric":[7,10],"oxide(NO)":[8],"and":[9,42,103,127,138],"oxide":[11],"synthase(NOS)":[12],"in":[13,51,67,81,107,132],"congenital":[14,24,119],"heart":[15,25,120],"defects":[16,26,121],"with":[17,23,54,70,84,110,118,123],"pulmonary":[18,33,39,74,105,111,124,136,150,153],"hypertension.":[19],"METHODS:":[20],"Twenty-four":[21],"patients":[22,69,109,117],"were":[27,76],"divided":[28],"into":[29],"3":[30],"groups:":[31],"mild":[32],"hypertension":[34,40,44,75,86,89,112,151],"group(n=8),":[35],"moderate":[36,71],"or":[37,72,87,152],"severe":[38,73],"group(n=9),":[41],"non-pulmonary":[43,88],"group(n=7).":[45],"NOS":[46,63,99,128,140],"mRNA":[47,64,100,141],"expression":[48,65,101,142],"was":[49,93,144],"detected":[50],"lung":[52],"tissues":[53],"reverse":[55],"transcriptase":[56],"polymerase":[57],"chain":[58],"reaction":[59],"(RT-PCR).":[60],"RESULTS:":[61],"The":[62],"levels":[66],"much":[77],"lower":[78],"than":[79],"those":[80],"ones":[83],"mild-pulmonary":[85],"(P":[90],"0.05).":[91],"There":[92],"an":[94],"inverse":[95],"correlation":[96],"between":[97],"level":[102,143],"arteriopathy":[106],"(r=-0.833,":[113],"P0.01).":[114],"CONCLUSION:":[115],"In":[116],"associated":[122],"hypertension,":[125],"NO":[126],"play":[129],"a":[130],"role":[131],"pathological":[133],"process":[134],"arteriopathy,":[137],"proportional":[145],"to":[146],"severity":[148],"arteriopathy.":[154]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}