{"id":"https://openalex.org/W2361374580","doi":null,"title":"Bcl 2, P53 protein expression and apoptosis in pancreatic cancer","display_name":"Bcl 2, P53 protein expression and apoptosis in pancreatic cancer","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2361374580","mag":"2361374580"},"language":"en","primary_location":{"id":"mag:2361374580","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XXHB199910007.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rong Yuan","orcid":"https://orcid.org/0000-0001-9996-7331","observed_orcids":["https://orcid.org/0000-0001-9996-7331"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rong Yuan","raw_affiliation_strings":["Wen  1, DING Qing  2, JIANG Han  Ying  1, QIN Xiu  Fu  2, ZOU Sheng  Quan  2 and XIA Sui  Sheng  1  Organ Transplantation Research Institute, Tongji Medical University, Wuhan 430030, Hubei Province, China"],"raw_orcid":"https://orcid.org/0000-0001-9996-7331","affiliations":[{"raw_affiliation_string":"Wen  1, DING Qing  2, JIANG Han  Ying  1, QIN Xiu  Fu  2, ZOU Sheng  Quan  2 and XIA Sui  Sheng  1  Organ Transplantation Research Institute, Tongji Medical University, Wuhan 430030, Hubei Province, China","institution_ids":["https://openalex.org/I4210160344"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210160344"],"apc_list":null,"apc_paid":null,"fwci":1.216,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79088715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.23909999430179596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p53-expression","display_name":"p53 expression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8659999966621399},{"id":"https://openalex.org/keywords/histological-grade","display_name":"histological grade","score":0.9929999709129333},{"id":"https://openalex.org/keywords/apoptotic-index","display_name":"apoptosis index","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.807580828666687},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.788368284702301},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7414261698722839},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.7155839204788208},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6848342418670654},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5509136319160461},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.46290338039398193},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42007026076316833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4125368595123291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3741082549095154},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3610617518424988},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34501197934150696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3208674490451813},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04762008786201477},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2361374580","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XXHB199910007.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2371824174","https://openalex.org/W1965856211","https://openalex.org/W2349550069","https://openalex.org/W2388443789","https://openalex.org/W2383345350","https://openalex.org/W2075740127","https://openalex.org/W1195249186","https://openalex.org/W2110037559","https://openalex.org/W2059315799","https://openalex.org/W1480921836"],"abstract_inverted_index":{"AIM":[0],"To":[1],"study":[2],"the":[3,149],"mechanism":[4],"of":[5,15,33,49,80,151],"bcl":[6],"2,":[7],"p":[8],"53":[9],"genes":[10],"and":[11,21,54,68,86,101,122,166],"apoptosis":[12],"in":[13,30,41,57,63,89,96,114,119,129,134],"carcinogenesis":[14,150],"pancreatic":[16,34,152],"cancer.":[17,35],"METHODS":[18],"Bcl":[19,81,130,135,144,164],"2":[20,82,131,136,145,165],"P53":[22,50,167],"protein":[23,51,83,168],"levels":[24],"were":[25,38],"detected":[26,39],"by":[27,40],"ABC":[28],"immunohistochemistry":[29],"50":[31],"cases":[32,138],"Apoptotic":[36],"cells":[37],"situ":[42],"end":[43],"labeling.":[44],"RESULTS":[45],"The":[46,77,161],"positive":[47,78],"rate":[48,79],"was":[52,84,111,170],"54%":[53],"much":[55,87,112],"lower":[56,113],"clinical":[58,90],"stage":[59,64,69,91,97,102],"\u2160(26":[60],"7%)":[61],"than":[62,95,118,133],"\u2161":[65,98,121],"(61":[66],"1%)":[67],"\u2162+\u2163":[70,103],"(70":[71],"6%,":[72],"P":[73,106,125,140,177],"0":[74,107,126,141,178],"05)":[75],".":[76],"64%":[85],"higher":[88,128],"\u2160":[92,117],"(93":[93],"3%)":[94],"(55":[99],"6%)":[100],"(47":[104],"1%,":[105],"05).":[108,179],"Apoptosis":[109],"index":[110],"histological":[115],"grade":[116,120],"\u2162":[123],"(":[124,139],"05),much":[127],"(-)":[132],"(+)":[137],"01).":[142],"CONCLUSION":[143],"may":[146],"indirectly":[147],"promote":[148],"cancer":[153],"as":[154],"an":[155],"important":[156],"gene":[157],"inhibiting":[158],"cell":[159],"apoptosis.":[160],"relationship":[162],"between":[163],"expression":[169],"reversely":[171],"correlated":[172],"(\u03c4=":[173],"-0":[174],"1747":[175],",":[176]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}