{"id":"https://openalex.org/W2361363944","doi":null,"title":"Treatment of multifocal osteosarcoma","display_name":"Treatment of multifocal osteosarcoma","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2361363944","mag":"2361363944"},"language":"en","primary_location":{"id":"mag:2361363944","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHGK200606004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764428191","display_name":"Zhonghua guke zazhi","issn_l":"0253-2352","issn":["0253-2352"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua guke zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112127275","display_name":"Shen Danhua","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shen Danhua","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5112127275"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.32839753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.5809999704360962},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8560000061988831},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.796999990940094},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ifosfamide","display_name":"ifosfamide","score":0.9020000100135803},{"id":"https://openalex.org/keywords/arsenic-trioxide","display_name":"arsenic trioxide","score":0.7749999761581421},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9950000047683716},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.9670000076293945},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.973997175693512},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.9495176672935486},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7375092506408691},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.6439885497093201},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6126498579978943},{"id":"https://openalex.org/C2777506904","wikidata":"https://www.wikidata.org/wiki/Q418560","display_name":"Ifosfamide","level":4,"score":0.6067280769348145},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.5243870615959167},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4958542287349701},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.42721980810165405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41166257858276367},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3942098617553711},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.19414928555488586},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15067535638809204},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.08453875780105591}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2361363944","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHGK200606004.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764428191","display_name":"Zhonghua guke zazhi","issn_l":"0253-2352","issn":["0253-2352"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua guke zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2108501999","https://openalex.org/W2146418734","https://openalex.org/W1964906310","https://openalex.org/W2007364774","https://openalex.org/W2116034353","https://openalex.org/W4401567662","https://openalex.org/W2004144935","https://openalex.org/W3134818568","https://openalex.org/W3200504766","https://openalex.org/W2355162807"],"abstract_inverted_index":{"Objective":[0],"To":[1,229],"discuss":[2],"the":[3,54,75,127,231],"treatment":[4],"and":[5,14,20,28,50,71,85,101,164,181,203,218],"prognosis":[6,210,232],"of":[7,41,53,156,171,179,211,233],"multifocal":[8,26,32,42,138,189,214,222,236],"osteosarcoma.":[9],"Methods":[10],"Between":[11],"January":[12],"1998":[13],"June":[15],"2005,":[16],"nine":[17,55],"patients(seven":[18],"males":[19],"two":[21,155,199],"females),":[22],"six":[23],"with":[24,30,59,187,201,213,220,235],"synchronous":[25,137],"osteosarcoma":[27,33,43,139,190,215,223],"three":[29],"metachronous":[31,188,221],"were":[34,83,88,103,135],"treated":[35],"in":[36,105,122,144],"our":[37],"department.":[38],"The":[39,209],"diagnosis":[40],"was":[44,120,151],"confirmed":[45],"by":[46],"clinical":[47],"presentation,":[48],"radiology":[49],"pathology.":[51],"Eight":[52],"patients":[56,106,133,186,212,219,234],"received":[57],"chemotherapy":[58,81,163],"adriamycin(60":[60],"mg/m2),":[61,63,68],"cisplatinum(100":[62],"high-dose":[64],"methotrexate(8-12":[65],"g/m2),":[66,70],"vincristine(1.4":[67],"ifosfamide(12.5":[69],"G-CSF.":[72],"Based":[73],"on":[74],"response":[76,161],"to":[77,90,95,110,126,146,162],"primary":[78,111],"chemotherapy,":[79],"further":[80],"plans":[82],"made,":[84],"different":[86],"operations":[87],"done":[89],"control":[91],"local":[92],"lesions":[93],"or":[94],"relieve":[96],"symptoms.":[97],"Arsenous":[98],"acid,":[99],"paclitaxel":[100],"VP-16":[102],"used":[104],"who":[107,116,134],"responded":[108],"poorly":[109],"chemotherapy.":[112],"Results":[113],"One":[114],"patient":[115],"given":[117],"up":[118],"remedy":[119],"died":[121,140],"systematic":[123],"fail":[124],"due":[125],"cancer":[128],"after":[129],"5":[130],"month,":[131],"five":[132],"diagnosed":[136],"from":[141],"progressive":[142],"disease":[143,202],"3.5":[145],"17":[147,182],"months":[148,183],"(mean":[149],"time":[150,178],"9.8":[152],"months).":[153],"Only":[154],"them":[157],"had":[158,165,174,191],"a":[159,175,192,196,225],"good":[160],"finished":[166],"at":[167],"least":[168],"four":[169],"cycles":[170],"chemotherapy,and":[172],"they":[173],"better":[176,193,227],"survival":[177],"15":[180],"respectively.":[184],"Three":[185],"prognosis.":[194,228],"After":[195],"two-year":[197],"follow-up,":[198],"lived":[200,205],"one":[204],"without":[206],"disease.":[207],"Conclusion":[208],"is":[216],"poor,":[217],"have":[224],"relatively":[226],"improve":[230],"osteosarcoma,":[237],"aggressive":[238],"chemother-apeutics":[239],"are":[240],"needed.":[241]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}