{"id":"https://openalex.org/W2361294552","doi":null,"title":"PRDM16 and brown adipocyte differentiation","display_name":"PRDM16 and brown adipocyte differentiation","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2361294552","mag":"2361294552"},"language":"en","primary_location":{"id":"mag:2361294552","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SMHX200901008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306529802","display_name":"Shengming de Huaxue","issn_l":"1000-1336","issn":["1000-1336"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chemistry of Life","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113745098","display_name":"Guo Xiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Guo Xiao","raw_affiliation_strings":["-Hong WANG Wei BIAN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"-Hong WANG Wei BIAN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113745098"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34728588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prdm16","display_name":"PRDM16","score":1.0},{"id":"https://openalex.org/keywords/brown-adipocyte-differentiation","display_name":"brown adipocyte differentiation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9309999942779541},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.8619999885559082},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/pgc-1beta","display_name":"PGC-1\u03b2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/myf5","display_name":"Myf5","score":0.8970000147819519},{"id":"https://openalex.org/keywords/obesity-treatment","display_name":"obesity treatment","score":0.7570000290870667},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C143128242","wikidata":"https://www.wikidata.org/wiki/Q18045527","display_name":"PRDM16","level":4,"score":0.9868742823600769},{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.72989821434021},{"id":"https://openalex.org/C81979416","wikidata":"https://www.wikidata.org/wiki/Q419493","display_name":"Thermogenin","level":4,"score":0.7133641242980957},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.6353510022163391},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.5839706659317017},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.543428361415863},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5073994994163513},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5004973411560059},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.49805259704589844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48412713408470154},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46819907426834106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44542258977890015},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.4266808331012726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3991811275482178},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35735002160072327},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27276870608329773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16351518034934998},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07557293772697449}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2361294552","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SMHX200901008.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306529802","display_name":"Shengming de Huaxue","issn_l":"1000-1336","issn":["1000-1336"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chemistry of Life","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2355025425","https://openalex.org/W2104827888","https://openalex.org/W2226424863","https://openalex.org/W4237178331","https://openalex.org/W1992326632","https://openalex.org/W1965478486","https://openalex.org/W3172901108","https://openalex.org/W2163468424","https://openalex.org/W1995253518","https://openalex.org/W2058131133"],"abstract_inverted_index":{"PRDM16(PR":[0],"domain":[1],"containing":[2],"16)":[3],"is":[4],"an":[5],"important":[6],"kind":[7],"of":[8,15],"transcriptional":[9],"regulator,which":[10],"can":[11,49],"activate":[12],"the":[13,43,58],"expression":[14],"brown":[16,36,71],"fat-related":[17],"genes,such":[18],"as":[19],"UCP1(uncoupling":[20],"protein":[21],"1),by":[22],"binding":[23],"itself":[24],"to":[25,60,69],"PPAR-\u03b3(peroxisome":[26],"proliferator-activated":[27],"receptor-\u03b3),PPAR-\u03b3":[28],"co-activator":[29],"1\u03b1(PGC-1\u03b1)":[30],"and":[31,52,63],"1\u03b2(PGC-1\u03b2).Through":[32],"this":[33],"way,PRDM16":[34],"stimulates":[35],"adipocyte":[37],"differentiation":[38],"from":[39],"precursor":[40],"cells":[41],"expressing":[42],"myogenic":[44],"regulatory":[45],"factor":[46],"gene":[47],"Myf5,which":[48],"increase":[50],"thermogenesis":[51],"reduce":[53],"fat":[54],"storage.These":[55],"researches":[56],"indicate":[57],"potential":[59],"treat":[61],"obesity":[62],"related":[64],"diseases":[65],"through":[66],"activating":[67],"PRDM16":[68],"produce":[70],"adipose":[72],"tissue.":[73]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
