{"id":"https://openalex.org/W2360350451","doi":null,"title":"Antitumor Effect of Sorafenib Combined with Itraconazole","display_name":"Antitumor Effect of Sorafenib Combined with Itraconazole","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2360350451","mag":"2360350451"},"language":"en","primary_location":{"id":"mag:2360350451","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHOU201304016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764999002","display_name":"Chinese Journal of Pharmaceuticals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727498","host_organization_name":"Shanghai Institute of Pharmaceutical Industry","host_organization_lineage":["https://openalex.org/P4361727498"],"host_organization_lineage_names":["Shanghai Institute of Pharmaceutical Industry"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Pharmaceuticals","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077343778","display_name":"Xiuhua Chen","orcid":"https://orcid.org/0000-0003-2134-3726","observed_orcids":["https://orcid.org/0000-0003-2134-3726"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xiuhua Chen","raw_affiliation_strings":["State Key Lab"],"raw_orcid":"https://orcid.org/0000-0003-2134-3726","affiliations":[{"raw_affiliation_string":"State Key Lab","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5077343778"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.47920000553131104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.47920000553131104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.23659999668598175,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.03480000048875809,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":1.0},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9789999723434448},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":1.0},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/b16-melanoma","display_name":"B16 melanoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7360000014305115},{"id":"https://openalex.org/keywords/g0-g1-phase","display_name":"G0/G1 phase","score":0.9520000219345093},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.8700000047683716},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/additive-effects","display_name":"additive effects","score":0.4399999976158142},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.7901977300643921},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7333011627197266},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.7109363079071045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.597779393196106},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5719029307365417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5426152348518372},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5136484503746033},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4946281611919403},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4767554700374603},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.4713318347930908},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4537499248981476},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.44417932629585266},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4437962770462036},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4110335409641266},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33889156579971313},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28236639499664307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21132397651672363},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1990574300289154},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13327237963676453},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.10393187403678894},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07667753100395203},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2360350451","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHOU201304016.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764999002","display_name":"Chinese Journal of Pharmaceuticals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4361727498","host_organization_name":"Shanghai Institute of Pharmaceutical Industry","host_organization_lineage":["https://openalex.org/P4361727498"],"host_organization_lineage_names":["Shanghai Institute of Pharmaceutical Industry"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Pharmaceuticals","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135808678","https://openalex.org/W7099274105","https://openalex.org/W2044468942","https://openalex.org/W2056203710","https://openalex.org/W1991248698","https://openalex.org/W2021491714","https://openalex.org/W2317071506","https://openalex.org/W2059516061","https://openalex.org/W2569207920","https://openalex.org/W4378472323"],"abstract_inverted_index":{"The":[0],"in":[1,40,97,100],"vitro":[2,98],"growth":[3],"inhibition":[4,42,68,102,130,153],"effects":[5,47,89],"of":[6,43,54,72,90,103,128,132,143,154,157],"sorafenib(1)":[7],"combined":[8,45,74,92],"with":[9,78,93,145],"itraconazole(2)":[10],"on":[11,48,69,95,135,152],"A549":[12,29],"human":[13,17,23,56],"lung":[14],"adenocarcinoma":[15],"cells,HCT116":[16],"colon":[18],"cancer":[19,25],"cells":[20,26,105],"and":[21,51,99,121,125],"MDA-MB-435":[22],"breast":[24],"were":[27,35,61,106],"investigated.The":[28],"tumor":[30,104],"bearing":[31,81],"nude":[32],"mouse":[33],"models":[34],"adopted":[36],"to":[37,139],"evaluate":[38],"the":[39,44,55,65,73,79,85,96,113,118,123,133],"vivo":[41,101],"regimen.The":[46],"cell":[49,114],"cycle,migration":[50],"vessel":[52,126],"formation":[53,127],"umbilical":[57],"vein":[58],"endothelial":[59],"cells(HUVEC)":[60],"also":[62,111,147],"investigated":[63],"at":[64,117],"cellular":[66],"level.The":[67],"pulmonary":[70,155],"metastasis":[71,156],"regimen":[75],"was":[76,137],"tested":[77],"mice":[80],"B16":[82,158],"melanoma":[83,159],"as":[84],"animal":[86],"models.The":[87],"additive":[88,150],"1":[91,140],"2":[94],"observed.The":[107],"combination":[108,134,142],"treatment":[109],"could":[110],"inhibit":[112,122],"cycle":[115],"progression":[116],"G0/G1":[119],"phase":[120],"migration":[124],"HUVEC.The":[129],"effect":[131,151],"HUVEC":[136],"superior":[138],"alone.The":[141],"sorafenib":[144],"itraconazole":[146],"displayed":[148],"an":[149],"tumor.":[160]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
