{"id":"https://openalex.org/W2360085461","doi":null,"title":"rhCD40L induces expression of matrix metalloproteinases in cultured U937 cells by cyclooxygenase-2 pathway","display_name":"rhCD40L induces expression of matrix metalloproteinases in cultured U937 cells by cyclooxygenase-2 pathway","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2360085461","mag":"2360085461"},"language":"en","primary_location":{"id":"mag:2360085461","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-XGNZ201101015.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764645039","display_name":"Chinese Heart Journal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Heart Journal","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102002907","display_name":"Qinqin Wang","orcid":"https://orcid.org/0000-0003-2741-1566","observed_orcids":["https://orcid.org/0000-0003-2741-1566","https://orcid.org/0000-0003-3625-5980"]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qinqin Wang","raw_affiliation_strings":["Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China"],"raw_orcid":"https://orcid.org/0000-0003-3625-5980","affiliations":[{"raw_affiliation_string":"Department of Cardiovasology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102002907"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27663026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.953000009059906},{"id":"https://openalex.org/keywords/u937-cells","display_name":"U937 cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ns-398","display_name":"NS-398","score":0.902999997138977},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mmp-secretion","display_name":"MMP secretion","score":0.4740000069141388},{"id":"https://openalex.org/keywords/dose-dependent-induction","display_name":"dose-dependent induction","score":0.5619999766349792},{"id":"https://openalex.org/keywords/gelatin-zymography","display_name":"gelatin zymography","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C108634530","wikidata":"https://www.wikidata.org/wiki/Q7863610","display_name":"U937 cell","level":3,"score":0.9213632345199585},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8777344226837158},{"id":"https://openalex.org/C177430391","wikidata":"https://www.wikidata.org/wiki/Q1173648","display_name":"Zymography","level":3,"score":0.8173667192459106},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.6850349307060242},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5458559989929199},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.499114990234375},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47173798084259033},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.45230913162231445},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.44918474555015564},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.34912219643592834},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2950476109981537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2768688201904297},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2523813247680664},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0556124746799469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04869171977043152}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2360085461","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-XGNZ201101015.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764645039","display_name":"Chinese Heart Journal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Heart Journal","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2381441990","https://openalex.org/W2361922632","https://openalex.org/W7067653640","https://openalex.org/W2155573803","https://openalex.org/W2158637841","https://openalex.org/W35802304","https://openalex.org/W199351475","https://openalex.org/W2260770349","https://openalex.org/W2258087137","https://openalex.org/W4313385215"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"evaluate":[2],"matrix":[3],"metalloproteinase(MMP)":[4],"expression":[5],"induced":[6,100],"by":[7,54,70,101],"rhCD40L":[8,23,77,103],"in":[9,26,56,83,111],"cultured":[10],"U937":[11,18,47,106],"cell":[12],"and":[13,24,42],"possible":[14],"effects":[15],"of":[16,32,45,66,74,81,92,98],"cyclooxygenase-2(COX-2).METHODS:":[17],"cells":[19,37,48,107],"were":[20,38,68],"treated":[21],"with":[22,35,40],"NS-398":[25,41,87],"different":[27],"concentrations,respectively,and":[28],"on":[29],"the":[30,33,46,71,75,79,90,96],"basis":[31],"treatment":[34],"rhCD40L,U937":[36],"cocultured":[39],"aspirin.The":[43],"supernatant":[44],"cultures":[49],"was":[50,52],"collected.Zymography":[51],"performed":[53],"SDS-PAGE":[55],"10%":[57],"gels":[58],"containing":[59],"0.1%(w/v)":[60],"gelatin(denatured":[61],"collagen)":[62],"at":[63],"4\u2103.The":[64],"activities":[65],"MMPs":[67,82,99,110],"detected":[69],"grey":[72],"level":[73],"band.RESULTS:":[76],"increased":[78],"activity":[80,91,97],"a":[84,112],"dose-dependent":[85,113],"manner,whereas":[86],"significantly":[88,94],"inhibited":[89,95],"MMPs.NS-398":[93],"rhCD40L.CONCLUSION:":[102],"can":[104],"induce":[105],"to":[108,118],"secrete":[109],"manner,which":[114],"may":[115],"be":[116],"related":[117],"COX-2":[119],"pathway.":[120]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}