{"id":"https://openalex.org/W2359999384","doi":null,"title":"Photoreceptor cell apoptosis of rat's retina induced by N-methyl-N-nitrosourea","display_name":"Photoreceptor cell apoptosis of rat's retina induced by N-methyl-N-nitrosourea","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W2359999384","mag":"2359999384"},"language":"en","primary_location":{"id":"mag:2359999384","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHYD200401010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764748524","display_name":"Zhonghua yandibing zazhi","issn_l":"1005-1015","issn":["1005-1015"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua yandibing zazhi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100525222","display_name":"Jinnan Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jinnan Yang","raw_affiliation_strings":["LING Shao-chun,   CHEN Jin-mao, et al"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LING Shao-chun,   CHEN Jin-mao, et al","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100525222"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31845882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.739300012588501,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.22120000422000885,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-methyl-n-nitrosourea","display_name":"N-methyl-N-nitrosourea","score":0.9490000009536743},{"id":"https://openalex.org/keywords/retinal-toxicity","display_name":"retinal toxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9850000143051147},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.9359999895095825},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/karyopyknosis","display_name":"karyopyknosis","score":0.9070000052452087},{"id":"https://openalex.org/keywords/internal-granular-layer","display_name":"internal granular layer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/rat-retina","display_name":"rat retina","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.7991946935653687},{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.756481409072876},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7096163034439087},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6654137372970581},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.6625158786773682},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6571397185325623},{"id":"https://openalex.org/C2778231335","wikidata":"https://www.wikidata.org/wiki/Q4113701","display_name":"Outer nuclear layer","level":3,"score":0.6401082873344421},{"id":"https://openalex.org/C2780916184","wikidata":"https://www.wikidata.org/wiki/Q748049","display_name":"Photoreceptor cell","level":3,"score":0.5686156153678894},{"id":"https://openalex.org/C2777506830","wikidata":"https://www.wikidata.org/wiki/Q4113799","display_name":"Inner nuclear layer","level":3,"score":0.4742416739463806},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4662064015865326},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4627212882041931},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42648908495903015},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3436131477355957},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3353736102581024},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31848517060279846},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.31368353962898254},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18505224585533142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15816205739974976},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10654768347740173},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2359999384","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZHYD200401010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764748524","display_name":"Zhonghua yandibing zazhi","issn_l":"1005-1015","issn":["1005-1015"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua yandibing zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2402749264","https://openalex.org/W211804280","https://openalex.org/W2371156648","https://openalex.org/W951329754","https://openalex.org/W97340538","https://openalex.org/W2382942240","https://openalex.org/W2387611742","https://openalex.org/W2349815721","https://openalex.org/W4290824920","https://openalex.org/W1988100131"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,6,55,108,111,122,133,172,203,219],"mechanism":[4],"of":[5,9,16,42,80,107,152,186,225],"toxic":[7],"effect":[8],"N-methyl-N-nitrosourea":[10],"(MNU)":[11],"on":[12,132],"photoreceptor":[13,59,144,220],"cell":[14,60,82,221],"apoptosis":[15,61,222],"rat\u2032s":[17],"retina.":[18],"Methods":[19],"Thirty":[20],"50-day-old":[21],"female":[22],"Sprague-Dawley":[23],"(":[24],"SD":[25],")":[26],"rats":[27],"were":[28,36],"intraperitoneally":[29],"injected":[30],"with":[31],"MNU":[32,215],"(60":[33],"mg/kg)":[34],"and":[35,48,51,74,87,119,128,131,160,165,177,188,194,208,223],"put":[37],"to":[38],"death":[39],"by":[40,64,100],"dislocation":[41],"cervical":[43],"vertebra":[44],"12,":[45],"24,":[46],"48,":[47],"72":[49,175,206],"hours":[50,147,168,199],"7":[52,181,212],"days":[53],"after":[54,98,137,148,169,174,180,200,205,211],"injection,":[56,170,201],"respectively.":[57],"The":[58,78,104,150,183],"was":[62,93,114,140,154,190],"detected":[63,94],"terminal":[65],"deoxynucleotidyl":[66],"transferase":[67],"mediated":[68],"dUTP":[69],"nick":[70],"end":[71],"labeling":[72],"(TUNEL)":[73],"transmission":[75],"electron":[76],"microscope.":[77],"expression":[79,151,185],"proliferating":[81],"nuclear":[83],"antigen":[84],"(PCNA),":[85],"vimentin":[86,189],"glial":[88],"fibrillary":[89],"acidic":[90],"protein":[91],"(GFAP)":[92],"at":[95,121],"different":[96],"time":[97],"injection":[99],"immunohistochemical":[101],"methods.":[102],"Results":[103],"apoptotic":[105],"index":[106],"retina":[109],"in":[110,142,156,192],"posterior":[112],"pole":[113],"(33.6\u00b12.3)%,":[115],"(46.5\u00b15.7)%,":[116],"(20.1\u00b15.3)%,":[117],"(8.2\u00b13.6)%":[118],"(2.5\u00b11.3%":[120],"12th,":[123],"24":[124,146,167,198],"th,":[125,127],"48":[126],"72nd":[129],"hour":[130],"7th":[134],"day,":[135],"respectively,":[136],"injection.":[138,149],"Karyopyknosis":[139],"found":[141,155,191],"most":[143],"cells":[145],"PCNA":[153],"internal":[157,162,193],"granular":[158,163,196],"layer":[159,164,197],"between":[161],"choroid":[166],"reached":[171,202],"peak":[173,204],"hours,":[176,207],"reduced":[178,209],"obviously":[179,210],"days.":[182,213],"positive":[184],"GFAP":[187],"external":[195],"Conclusion":[214],"may":[216],"selectively":[217],"lead":[218],"proliferation":[224],"Muller":[226],"cells.":[227]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
