{"id":"https://openalex.org/W2359969596","doi":null,"title":"Hhepatocyte growth factor stimulate vascular endothelial growth factor secretion in ovarian cancer cell line and its signal transduction pathway","display_name":"Hhepatocyte growth factor stimulate vascular endothelial growth factor secretion in ovarian cancer cell line and its signal transduction pathway","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2359969596","mag":"2359969596"},"language":"en","primary_location":{"id":"mag:2359969596","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-FKLC200506010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764932434","display_name":"Chinese Journal of Clinical Obstetrics and Gynecology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Clinical Obstetric and Gynecology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067360424","display_name":"Lu YanMing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lu YanMing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067360424"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1797217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":1.0},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9279999732971191},{"id":"https://openalex.org/keywords/skov-3-cells","display_name":"SKOV3 cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8029999732971191},{"id":"https://openalex.org/keywords/pyrrolidine-dithiocarbamate","display_name":"pyrrolidine dithiocarbamate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7900000214576721},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.5989999771118164},{"id":"https://openalex.org/keywords/vegf-expression-regulation","display_name":"VEGF expression regulation","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C2776996007","wikidata":"https://www.wikidata.org/wiki/Q2399112","display_name":"Hepatocyte growth factor","level":3,"score":0.8968405723571777},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.6805235147476196},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6113536357879639},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5663366317749023},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5234572291374207},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4703308045864105},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4593806862831116},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.44295793771743774},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4253532290458679},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4118039309978485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38483989238739014},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3559795320034027},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34775254130363464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26648086309432983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25335684418678284},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19519689679145813},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.12125766277313232},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06414201855659485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.053335219621658325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.048119306564331055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2359969596","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-FKLC200506010.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764932434","display_name":"Chinese Journal of Clinical Obstetrics and Gynecology","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Chinese Journal of Clinical Obstetric and Gynecology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2360302137","https://openalex.org/W3032867961","https://openalex.org/W1968535565","https://openalex.org/W957105284","https://openalex.org/W7135640620","https://openalex.org/W2064412032","https://openalex.org/W86733458","https://openalex.org/W2357846250","https://openalex.org/W284977140","https://openalex.org/W3022860198"],"abstract_inverted_index":{"Objective":[0],"To":[1],"observe":[2],"the":[3,48,71,101,105,116,126],"effects":[4],"of":[5,44,73,88,118,128],"hepatocyte":[6],"growth":[7,11],"factor(HGF)on":[8],"vascular":[9],"endothelial":[10],"factor(VEGF)in":[12],"ovarian":[13,22,79,131],"epithelial":[14],"cancer":[15,23,80,132],"cells(SKOV3)and":[16],"its":[17],"signal":[18],"transduction":[19],"pathway.Methods":[20],"The":[21],"cells":[24,49,106],"was":[25,50,92],"treated":[26,36,108],"with":[27,37,109],"HGF":[28,69,95,110,124],"at":[29,133],"different":[30],"concentration":[31],"and":[32,66,76,100,135],"for":[33,111],"varied":[34],"time,or":[35],"Nuclear":[38],"factor":[39],"kB(NFkB)inhibitor":[40],"PDTC.The":[41],"expression":[42,72,117,127],"level":[43,137],"VEGF":[45,64,74,129],"mRNA":[46,75,134],"in":[47,78,84,96,130],"evaluated":[51],"by":[52,94,122],"relative":[53],"quantitative":[54],"reserve-transcription":[55],"polymerase":[56],"chain":[57],"reaction(RT-PCR).Western":[58],"blot":[59],"were":[60,107],"used":[61],"to":[62],"examine":[63],"protein":[65,77,91,120,136],"NFkB":[67,90,119,139],"protein.Results":[68],"increased":[70,93],"cell":[81],"line":[82],"SKOV3":[83],"dose-and":[85],"time-dependant":[86,98],"manner.Expression":[87],"nucleus":[89],"a":[97],"manner":[99],"peak":[102],"appeared":[103],"when":[104],"1":[112],"hour.However,PDTC":[113],"significantly":[114],"inhibited":[115],"induced":[121],"HGF.Conclusion":[123],"modulates":[125],"via":[138],"pathway.":[140]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
