{"id":"https://openalex.org/W2359720644","doi":null,"title":"Osthole attenuates learning and memory deficits and neuronal ultrastructure in CA1 region of hippocampus induced by Abeta 25-35 fragment in rats","display_name":"Osthole attenuates learning and memory deficits and neuronal ultrastructure in CA1 region of hippocampus induced by Abeta 25-35 fragment in rats","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2359720644","mag":"2359720644"},"language":"en","primary_location":{"id":"mag:2359720644","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZYYB201104007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306500210","display_name":"Acta Academiae Medicinae Zunyi","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Academiae Medicinae Zunyi","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100676811","display_name":"Danli Yang","orcid":"https://orcid.org/0000-0003-2346-6404","observed_orcids":["https://orcid.org/0000-0003-2346-6404"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Danli Yang","raw_affiliation_strings":["Department of Pharmacology,Zunyi Medical College,Guizhou Zunyi 563000)"],"raw_orcid":"https://orcid.org/0000-0003-2346-6404","affiliations":[{"raw_affiliation_string":"Department of Pharmacology,Zunyi Medical College,Guizhou Zunyi 563000)","institution_ids":["https://openalex.org/I182386381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100676811"],"corresponding_institution_ids":["https://openalex.org/I182386381"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.24029751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osthole","display_name":"osthole","score":1.0},{"id":"https://openalex.org/keywords/amyloid-beta-25-35","display_name":"amyloid beta 25-35","score":0.8809999823570251},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8920000195503235},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.9459999799728394},{"id":"https://openalex.org/keywords/hippocampal-ca1","display_name":"hippocampal CA1","score":0.7940000295639038},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.8960000276565552},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.75}],"concepts":[{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.8142907619476318},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.8071626424789429},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.6473892331123352},{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.5463250279426575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5006935596466064},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.484096884727478},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.47644951939582825},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.4587900638580322},{"id":"https://openalex.org/C12515866","wikidata":"https://www.wikidata.org/wiki/Q50628021","display_name":"Water maze","level":3,"score":0.4483746290206909},{"id":"https://openalex.org/C2776993930","wikidata":"https://www.wikidata.org/wiki/Q1598902","display_name":"Stereology","level":2,"score":0.4398777484893799},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.4397600293159485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42774614691734314},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4123152494430542},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35601121187210083},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3213478922843933},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31243371963500977},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08455204963684082},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.07385772466659546},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.06526497006416321}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2359720644","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZYYB201104007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4306500210","display_name":"Acta Academiae Medicinae Zunyi","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta Academiae Medicinae Zunyi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2186846380","https://openalex.org/W2804903936","https://openalex.org/W2362549575","https://openalex.org/W2361116179","https://openalex.org/W2356175238","https://openalex.org/W2383067951","https://openalex.org/W2370299707","https://openalex.org/W1987725130","https://openalex.org/W2360752253","https://openalex.org/W2071900841"],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"the":[3,145,176],"protective":[4],"effect":[5],"of":[6,19,47,64,96,109,113,125,134,165],"osthole":[7,61,170],"on":[8],"learning":[9,85,110,198],"and":[10,13,68,86,89,111,199,202],"memory":[11,87,112,200],"deficits":[12,88,201],"neuronal":[14,90,159,189,203],"ultrastructure":[15,91,121,160,190,204],"in":[16,122,144,153,162,175,184,192,209],"CA1":[17,123,163],"region":[18,124,164],"hippocampus":[20,126],"induced":[21,93,206],"by":[22,52,77,94,117,129,207],"Abeta":[23],"25-35":[24],"fragment(A\u03b225-35)in":[25],"rats.Methods":[26],"Forty":[27],"male":[28],"Sprague":[29],"Dawley":[30],"rats":[31,114],"were":[32,41,58,71],"randomly":[33],"divided":[34],"equally":[35],"into":[36],"sham,model,positive-and":[37],"osthole-treated":[38],"groups.Positive-treated":[39],"groups":[40,57,70],"administrated":[42,59,72],"with":[43,60,73,84,167],"donepezil":[44,168],"at":[45,62],"doses":[46,63],"1.0":[48],"mg/kg":[49],"once":[50],"daily":[51],"gavage":[53],"consecutive":[54],"for":[55,81],"17d,osthole-treated":[56],"40":[65],"mg/kg,while":[66],"sham":[67],"model":[69,83,106],"volume-matched":[74],"normal":[75],"saline":[76],"gavage,instead.After":[78],"having":[79],"treated":[80],"3d,rat":[82],"was":[92,115,127],"injection":[95,157],"A\u03b225-35":[97,135,208],"to":[98,136],"lateral":[99,137],"cerebral":[100,138],"ventricle.And":[101],"10":[102],"d":[103],"later":[104],"after":[105],"establishment,the":[107],"ability":[108],"tested":[116],"Morris":[118],"water":[119],"maze,neuronal":[120],"observed":[128],"transmission":[130],"electron":[131],"microscopy.Results":[132],"Injection":[133],"ventricle":[139],"significantly":[140,171],"increased":[141,180],"eseape":[142,151,173,182],"latencey":[143,152],"place":[146,177],"navigation":[147,178],"test,and":[148,179,187],"decreased":[149],"adjusted":[150,181],"spatial":[154,185,197],"probe":[155,186],"test(P0.01).Meanwhile,A\u03b225-35":[156],"caused":[158],"injury":[161,191,205],"hippocampus.However,treatments":[166],"or":[169],"shortened":[172],"latency":[174,183],"attenuated":[188],"hippocampus.Conclusion":[193],"Osthole":[194],"may":[195],"attenuate":[196],"rats.":[210]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}