{"id":"https://openalex.org/W2359516495","doi":null,"title":"[Pharmacological activities of Z-ligustilide and metabolites in rats].","display_name":"[Pharmacological activities of Z-ligustilide and metabolites in rats].","publication_year":2009,"publication_date":"2009-09-01","ids":{"openalex":"https://openalex.org/W2359516495","mag":"2359516495","pmid":"https://pubmed.ncbi.nlm.nih.gov/19950595"},"language":"zh","primary_location":{"id":"pmid:19950595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19950595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015594980","display_name":"Jiajing Tang","orcid":"https://orcid.org/0000-0001-9928-7918","observed_orcids":["https://orcid.org/0000-0001-9928-7918"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Tang","raw_affiliation_strings":["Department of Pharmacology & Biopharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu, China","Department of Pharmacology and Biopharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Biopharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]},{"raw_affiliation_string":"Department of Pharmacology and Biopharmaceutics, West China School of Pharmacy, Sichuan University, Chengdu, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013447592","display_name":"C Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072871743","display_name":"Yang Yu","orcid":"https://orcid.org/0000-0001-9052-1245","observed_orcids":["https://orcid.org/0000-0001-9052-1245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109869740","display_name":"Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun-Rong Du","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wen Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Cheng-Yuan Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng-Yuan Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.8749,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.90452783,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"40","issue":"5","first_page":"839","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.49729999899864197,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.49729999899864197,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":0.19750000536441803,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/z-ligustilide","display_name":"Z-ligustilide","score":0.9929999709129333},{"id":"https://openalex.org/keywords/senkyunolide-i","display_name":"senkyunolide I","score":0.921999990940094},{"id":"https://openalex.org/keywords/biotransformation","display_name":"biotransformation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/metabolites","display_name":"metabolites","score":0.718999981880188},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5690000057220459},{"id":"https://openalex.org/keywords/hydrogen-peroxide-induced-injury","display_name":"hydrogen peroxide-induced injury","score":0.906000018119812},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.9129999876022339},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9580000042915344},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.8725681304931641},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.663196861743927},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.650287926197052},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6315641403198242},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.6196850538253784},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5866121053695679},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.5849858522415161},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4404716193675995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3860247731208801},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37782490253448486},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.31184977293014526},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22735440731048584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15157201886177063},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001572","descriptor_name":"Benzofurans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015107","descriptor_name":"4-Butyrolactone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19950595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19950595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","raw_type":"Journal Article"},{"id":"mag:2359516495","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19950595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099961950","https://openalex.org/W2071871783","https://openalex.org/W2799636739","https://openalex.org/W3093476344","https://openalex.org/W2015415371","https://openalex.org/W4288036681","https://openalex.org/W2067376880","https://openalex.org/W3021489017","https://openalex.org/W2052342909","https://openalex.org/W2002541732"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,15,93,110,133],"metabolism":[4],"of":[5,18,27,71,92,95,113,136],"Z-ligustilide(Z-LIG)":[6],"in":[7,10,12,22,29,31,43,84,104,127,138,150],"vivo":[8,32],"and":[9,14,20,51,67,73,117,121,141],"vitro":[11,105],"rats":[13,30],"pharmacological":[16],"activities":[17],"Z-LIG":[19,28,35,72,96,116,137,140],"metabolites":[21,76,94],"vitro.":[23,44],"METHODS:":[24],"The":[25,45,69,89],"biotransformation":[26],"was":[33,36,48,97,107],"tested.":[34],"also":[37],"incubated":[38,46],"with":[39,53],"rat":[40],"liver":[41],"microsomes":[42],"product":[47],"extracted,":[49],"separated":[50],"identified":[52,108],"high":[54,59],"performance":[55],"liquid":[56],"chromatography":[57],"(HPLC),":[58],"resolution":[60],"mass":[61],"spectrometry,":[62],"nuclear":[63],"magnetic":[64],"resonance":[65],"spectrum":[66],"UV.":[68],"effects":[70,146],"its":[74],"main":[75,111,134],"on":[77],"hydrogen":[78],"peroxide":[79],"(H1O2)-induced":[80],"injuries":[81,126],"were":[82],"examined":[83],"cultured":[85,151],"PC12":[86,128,152],"cells.":[87,129,153],"RESULTS:":[88],"HPLC":[90],"analysis":[91],"obtained.":[98],"Senkyunolide":[99],"I":[100],"(SYL)":[101],"isolated":[102],"from":[103],"incubation":[106],"as":[109],"metabolite":[112,135],"Z-LIG.":[114],"Both":[115],"SYL":[118,131,142],"showed":[119],"significant":[120],"concentration-dependent":[122],"protection":[123],"against":[124,147],"H2O2-induced":[125],"CONCLUSION:":[130],"is":[132],"rats.":[139],"exert":[143],"similar":[144],"protective":[145],"oxidative":[148],"damage":[149]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}