{"id":"https://openalex.org/W2358725439","doi":null,"title":"A Protective Role of Nrf2 in Inflammatory Disorders","display_name":"A Protective Role of Nrf2 in Inflammatory Disorders","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2358725439","mag":"2358725439"},"language":"en","primary_location":{"id":"mag:2358725439","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-YWSW201304018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764532358","display_name":"Pharmaceutical biotechnology","issn_l":"1078-0467","issn":["1078-0467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical biotechnology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105771579","display_name":"Min Ye","orcid":"https://orcid.org/0009-0007-9029-5904","observed_orcids":["https://orcid.org/0009-0007-9029-5904"]},"institutions":[{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Min Ye","raw_affiliation_strings":["School of Pharmacy, China Pharmaceutical University"],"raw_orcid":"https://orcid.org/0009-0007-9029-5904","affiliations":[{"raw_affiliation_string":"School of Pharmacy, China Pharmaceutical University","institution_ids":["https://openalex.org/I161716053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5105771579"],"corresponding_institution_ids":["https://openalex.org/I161716053"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.18660595,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-response-element","display_name":"antioxidant response element","score":0.7829999923706055},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8569999933242798},{"id":"https://openalex.org/keywords/electrophilic-stress","display_name":"electrophilic stress","score":0.9269999861717224},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6449999809265137},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/emphysema","display_name":"emphysema","score":0.9789999723434448},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7379999756813049},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.722000002861023},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7020000219345093},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7386020421981812},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6397420167922974},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5894138216972351},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5743917226791382},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4822174310684204},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44143950939178467},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4191458821296692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40299955010414124},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3745447099208832},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3390704393386841},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10854166746139526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09861454367637634}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2358725439","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-YWSW201304018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764532358","display_name":"Pharmaceutical biotechnology","issn_l":"1078-0467","issn":["1078-0467"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutical biotechnology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6903118858","https://openalex.org/W4415236864","https://openalex.org/W3027780031","https://openalex.org/W2143375187","https://openalex.org/W2043038263","https://openalex.org/W1518106396","https://openalex.org/W1019479792","https://openalex.org/W2972226533","https://openalex.org/W2779339038","https://openalex.org/W2404173614"],"abstract_inverted_index":{"Nuclear":[0],"factor-erythroid":[1],"2-related":[2],"factor-2(Nrf2)":[3],"is":[4,42,106],"a":[5,11],"key":[6],"transcription":[7,153],"factor":[8],"that":[9,39,108],"plays":[10],"central":[12],"role":[13,136],"in":[14,45,139],"cellular":[15],"defense":[16],"against":[17],"oxidative":[18,68],"and":[19,27,31,53,69,101,124],"electrophilic":[20,70],"insults":[21],"by":[22,115,150],"timely":[23],"induction":[24,128],"of":[25,57,80,85,93,112,129,137],"antioxidative":[26],"phase-2":[28],"detoxifying":[29],"enzymes":[30],"related":[32],"stressresponse":[33],"proteins.The":[34],"recent":[35],"studies":[36],"have":[37],"demonstrated":[38],"Nrf2-ARE":[40,86],"signaling":[41,59,148],"also":[43,73,125],"involved":[44],"attenuating":[46],"inflammation-associated":[47],"pathogenesis,such":[48],"as":[49],"autoimmune":[50],"diseases,rheumatoid":[51],"arthritis,asthma,emphysema,gastritis,colitis":[52],"atherosclerosis.Thus,disruption":[54],"or":[55,91],"loss":[56],"Nrf2":[58,116,138],"may":[60,117],"cause":[61],"the":[62,78,89,109,120,127,134,146],"enhanced":[63],"susceptibility":[64],"not":[65],"only":[66],"to":[67,74],"stresses":[71],"but":[72],"inflammatory":[75,147],"tissue":[76,82],"injuries.During":[77],"early-phase":[79],"inflammation-mediated":[81,140],"damage,the":[83],"activation":[84],"might":[87],"inhibit":[88],"production":[90],"expression":[92],"pro-inflammatory":[94,130],"mediators":[95],"including":[96],"cytokines,chemokines,cell":[97],"adhesion":[98],"molecules,matrix":[99],"metalloproteinases,cyclooxygenase-2":[100],"inducible":[102],"nitric":[103],"oxide":[104],"synthase.It":[105],"likely":[107],"cytoprotective":[110],"function":[111],"genes":[113],"targeted":[114],"cooperatively":[118],"regulate":[119],"innate":[121],"immune":[122],"response":[123],"repress":[126],"genes.This":[131],"review":[132],"highlights":[133],"protective":[135],"disorders":[141],"with":[142],"special":[143],"focus":[144],"on":[145],"modulated":[149],"this":[151],"redox-regulated":[152],"factor.":[154]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}
