{"id":"https://openalex.org/W2357971202","doi":null,"title":"Synergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells.","display_name":"Synergistic combinations of tanshinone IIA and trans-resveratrol toward cisplatin-comparable cytotoxicity in HepG2 human hepatocellular carcinoma cells.","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2357971202","mag":"2357971202","pmid":"https://pubmed.ncbi.nlm.nih.gov/25275043"},"language":"en","primary_location":{"id":"pmid:25275043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25275043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102301401","display_name":"Tung-Wu Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4405266015","display_name":"Hualien District Agricultural Research and Extension Station Council of Agriculture","ror":"https://ror.org/04b1aht43","country_code":"TW","type":"government","lineage":["https://openalex.org/I4405266015"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Wu Chang","raw_affiliation_strings":["Department of Agronomy, National Taiwan University, Taipei, Taiwan, R.O.C Division of Crop Improvement, Hualien District Agricultural Research and Extension Station, Council of Agriculture, Hualien County, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agronomy, National Taiwan University, Taipei, Taiwan, R.O.C Division of Crop Improvement, Hualien District Agricultural Research and Extension Station, Council of Agriculture, Hualien County, Taiwan, R.O.C","institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4405266015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100857749","display_name":"Chueh-Yu Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chueh-Yu Lin","raw_affiliation_strings":["Institute of Medical Sciences, Tzu-Chi University, Hualien City, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Sciences, Tzu-Chi University, Hualien City, Taiwan, R.O.C","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004558779","display_name":"Yin\u2010Jeh Tzeng","orcid":"https://orcid.org/0000-0001-6767-7452","observed_orcids":["https://orcid.org/0000-0001-6767-7452"]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yin-Jeh Tzeng","raw_affiliation_strings":["Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien City, Taiwan, R.O.C tzeng@mail.tcu.edu.tw tzeng@gms.tcu.edu.tw lurhs@ntu.edu.tw","Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien City, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien City, Taiwan, R.O.C tzeng@mail.tcu.edu.tw tzeng@gms.tcu.edu.tw lurhs@ntu.edu.tw","institution_ids":["https://openalex.org/I189772984"]},{"raw_affiliation_string":"Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien City, Taiwan, R.O.C","institution_ids":["https://openalex.org/I189772984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017921770","display_name":"Huu\u2010Sheng Lur","orcid":"https://orcid.org/0000-0003-2485-9875","observed_orcids":["https://orcid.org/0000-0003-2485-9875"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Huu-Sheng Lur","raw_affiliation_strings":["Department of Agronomy, National Taiwan University, Taipei, Taiwan, R.O.C tzeng@mail.tcu.edu.tw tzeng@gms.tcu.edu.tw lurhs@ntu.edu.tw","Department of Agronomy, National Taiwan University, Taipei, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Agronomy, National Taiwan University, Taipei, Taiwan, R.O.C tzeng@mail.tcu.edu.tw tzeng@gms.tcu.edu.tw lurhs@ntu.edu.tw","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Department of Agronomy, National Taiwan University, Taipei, Taiwan, R.O.C","institution_ids":["https://openalex.org/I16733864"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5771,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.94581686,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"10","first_page":"5473","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.6851000189781189,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tanshinone-iia","display_name":"tanshinone IIA","score":1.0},{"id":"https://openalex.org/keywords/trans-resveratrol","display_name":"trans-resveratrol","score":0.9919999837875366},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.6399999856948853},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.949999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.9415757656097412},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8474754691123962},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.8148506879806519},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7378880977630615},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.7128496170043945},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.5831859707832336},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.5825599431991577},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5805448293685913},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.564898669719696},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5503713488578796},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.49732282757759094},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.47655728459358215},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4369908571243286},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43232667446136475},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.356306254863739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.310022234916687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24197569489479065},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1338791847229004},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06832420825958252},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0538066029548645},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077185","descriptor_name":"Resveratrol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013267","descriptor_name":"Stilbenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D045784","descriptor_name":"Abietanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056945","descriptor_name":"Hep G2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059447","descriptor_name":"Cell Cycle Checkpoints","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25275043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25275043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2357971202","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25275043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W47809698","https://openalex.org/W47894982","https://openalex.org/W1585576985","https://openalex.org/W1979569154","https://openalex.org/W1981989535","https://openalex.org/W1999237090","https://openalex.org/W2003286160","https://openalex.org/W2004107289","https://openalex.org/W2008936830","https://openalex.org/W2011396543","https://openalex.org/W2017945551","https://openalex.org/W2049239878","https://openalex.org/W2049502294","https://openalex.org/W2051029757","https://openalex.org/W2052560004","https://openalex.org/W2071902341","https://openalex.org/W2081882557","https://openalex.org/W2085039455","https://openalex.org/W2085423369","https://openalex.org/W2106787323","https://openalex.org/W2111989524","https://openalex.org/W2122188209","https://openalex.org/W2124157955","https://openalex.org/W2125065061","https://openalex.org/W2128215898","https://openalex.org/W2134634216","https://openalex.org/W2157534045","https://openalex.org/W2171199875","https://openalex.org/W2352505828","https://openalex.org/W2412157505","https://openalex.org/W2494366594","https://openalex.org/W2785982436"],"related_works":["https://openalex.org/W2354943095","https://openalex.org/W2554713683","https://openalex.org/W2977987787","https://openalex.org/W2969119912","https://openalex.org/W4402783524","https://openalex.org/W2381926317","https://openalex.org/W1840775025","https://openalex.org/W2364973605","https://openalex.org/W3006056689","https://openalex.org/W2893342273"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"determine":[2],"the":[3,35,90,149],"combinative":[4,91],"effects":[5],"of":[6,67,77,81,98,106,148],"tanshinone":[7],"IIA":[8,61,122],"(Tan":[9],"IIA)":[10],"and":[11,19,38,44,62,69,83,123,129,137],"trans-resveratrol":[12],"(Resv)":[13],"on":[14],"cytotoxicity,":[15],"apoptosis,":[16,132],"cell-cycle":[17],"arrest":[18,43,136],"DNA":[20,52,108,138],"fragmentation":[21,109],"in":[22,89,93,112,116],"HepG2":[23],"human":[24],"liver":[25],"cancer":[26],"cells.":[27],"MATERIALS":[28],"AND":[29],"METHODS:":[30],"Cytotoxicity":[31],"was":[32,110],"detected":[33],"by":[34,56],"cell":[36,134],"proliferation":[37],"cytotoxicity":[39,73,128],"WST-1":[40],"assay.":[41],"Cell-cycle":[42],"apoptosis":[45],"were":[46,54,86],"determined":[47],"using":[48],"flow":[49],"cytometry":[50],"analysis.":[51],"fragments":[53],"separated":[55],"gel":[57],"electrophoresis.":[58],"RESULTS:":[59],"Tan":[60,121],"Resv":[63,124],"at":[64],"mixture":[65],"ratios":[66],"1/2:1/2":[68],"1/3:2/3":[70],"exerted":[71],"synergistic":[72,126],"comparable":[74],"to":[75],"that":[76],"cisplatin.":[78],"Elevated":[79],"proportions":[80],"sub-G1":[82,133],"apoptotic":[84,107],"cells":[85],"respectively":[87],"found":[88],"treatments":[92,114],"comparison":[94],"with":[95],"hypothetic":[96],"values":[97],"additive":[99],"effects.":[100],"Moreover,":[101],"a":[102],"more":[103],"intensive":[104],"pattern":[105],"visualized":[111],"combined":[113],"than":[115],"individual":[117],"ones.":[118],"CONCLUSION:":[119],"Combining":[120],"causes":[125],"cisplatin-comparable,":[127],"robustly":[130],"induces":[131],"cycle":[135],"fragmentation.":[139],"This":[140],"study":[141],"provides":[142],"evidence":[143],"supporting":[144],"further":[145],"pre-clinical":[146],"investigations":[147],"combinational":[150],"synergism.":[151]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
