{"id":"https://openalex.org/W2357770486","doi":"https://doi.org/10.1016/j.toxicon.2016.05.005","title":"Functional characterizations of venom phenotypes in the eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for expression-driven divergence in toxic activities among populations","display_name":"Functional characterizations of venom phenotypes in the eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for expression-driven divergence in toxic activities among populations","publication_year":2016,"publication_date":"2016-05-11","ids":{"openalex":"https://openalex.org/W2357770486","doi":"https://doi.org/10.1016/j.toxicon.2016.05.005","mag":"2357770486","pmid":"https://pubmed.ncbi.nlm.nih.gov/27179420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5178144"},"language":"en","primary_location":{"id":"doi:10.1016/j.toxicon.2016.05.005","doi":"https://doi.org/10.1016/j.toxicon.2016.05.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxicon.2016.05.005","pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0041010116301349?via%3Dihub","source":{"id":"https://openalex.org/S42803210","display_name":"Toxicon","issn_l":"0041-0101","issn":["0041-0101","1879-3150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/am/pii/S0041010116301349?via%3Dihub","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074009978","display_name":"Mark J. Margres","orcid":"https://orcid.org/0000-0002-6153-6701","observed_orcids":["https://orcid.org/0000-0002-6153-6701"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Margres","raw_affiliation_strings":["Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091611764","display_name":"Robert Walls","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181414168","display_name":"Texas A&M University \u2013 Kingsville","ror":"https://ror.org/05abs3w97","country_code":"US","type":"education","lineage":["https://openalex.org/I181414168"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Walls","raw_affiliation_strings":["National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA","institution_ids":["https://openalex.org/I181414168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036671721","display_name":"Montamas Suntravat","orcid":"https://orcid.org/0000-0001-8955-7806","observed_orcids":["https://orcid.org/0000-0001-8955-7806"]},"institutions":[{"id":"https://openalex.org/I181414168","display_name":"Texas A&M University \u2013 Kingsville","ror":"https://ror.org/05abs3w97","country_code":"US","type":"education","lineage":["https://openalex.org/I181414168"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Montamas Suntravat","raw_affiliation_strings":["National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA","institution_ids":["https://openalex.org/I181414168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111569115","display_name":"Sara E. Lucena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181414168","display_name":"Texas A&M University \u2013 Kingsville","ror":"https://ror.org/05abs3w97","country_code":"US","type":"education","lineage":["https://openalex.org/I181414168"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Lucena","raw_affiliation_strings":["National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA","institution_ids":["https://openalex.org/I181414168"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021210234","display_name":"Elda Eliza Sanchez","orcid":"https://orcid.org/0000-0001-5222-8873","observed_orcids":["https://orcid.org/0000-0001-5222-8873"]},"institutions":[{"id":"https://openalex.org/I181414168","display_name":"Texas A&M University \u2013 Kingsville","ror":"https://ror.org/05abs3w97","country_code":"US","type":"education","lineage":["https://openalex.org/I181414168"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elda E. S\u00e1nchez","raw_affiliation_strings":["National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA; Department of Chemistry, Texas A&M University-Kingsville, MSC 161, Kingsville, TX 78363, USA","Department of Chemistry, Texas A&M University-Kingsville, MSC 161, Kingsville, TX 78363, USA","National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA; Department of Chemistry, Texas A&M University-Kingsville, MSC 161, Kingsville, TX 78363, USA","institution_ids":["https://openalex.org/I181414168"]},{"raw_affiliation_string":"Department of Chemistry, Texas A&M University-Kingsville, MSC 161, Kingsville, TX 78363, USA","institution_ids":["https://openalex.org/I181414168"]},{"raw_affiliation_string":"National Natural Toxins Research Center (NNTRC), Texas A&M University-Kingsville, MSC 158, 975 West Avenue B, Kingsville, TX 78363, USA","institution_ids":["https://openalex.org/I181414168"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089949345","display_name":"Darin R. Rokyta","orcid":"https://orcid.org/0000-0002-0356-2178","observed_orcids":["https://orcid.org/0000-0002-0356-2178"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Darin R. Rokyta","raw_affiliation_strings":["Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA. Electronic address: drokyta@bio.fsu.edu","Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA. Electronic address: drokyta@bio.fsu.edu","institution_ids":["https://openalex.org/I103163165"]},{"raw_affiliation_string":"Department of Biological Science, Florida State University, Tallahassee, FL 32306-4295, USA","institution_ids":["https://openalex.org/I103163165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5089949345"],"corresponding_institution_ids":["https://openalex.org/I103163165"],"apc_list":{"value":3340,"currency":"USD","value_usd":3340},"apc_paid":null,"fwci":5.6383,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.96170396,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"119","issue":null,"first_page":"28","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10332","display_name":"Amphibian and Reptile Biology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eastern-diamondback-rattlesnake","display_name":"eastern diamondback rattlesnake","score":0.9679999947547913},{"id":"https://openalex.org/keywords/crotalus-adamanteus","display_name":"Crotalus adamanteus","score":1.0},{"id":"https://openalex.org/keywords/snake-venom","display_name":"snake venom","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hemolytic-activity","display_name":"hemolytic activity","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gelatinase-activity","display_name":"gelatinase activity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/fibrinogenolytic-activity","display_name":"fibrinogenolytic activity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/coagulant-activity","display_name":"coagulant activity","score":0.890999972820282},{"id":"https://openalex.org/keywords/venom-toxicity","display_name":"venom toxicity","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.8365965485572815},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5768411159515381},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5154377222061157},{"id":"https://openalex.org/C2780331750","wikidata":"https://www.wikidata.org/wiki/Q463637","display_name":"Crotalus","level":3,"score":0.4793477952480316},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2876986265182495},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.14596959948539734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1067202091217041}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D003435","descriptor_name":"Crotalid Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017839","descriptor_name":"Crotalus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.toxicon.2016.05.005","doi":"https://doi.org/10.1016/j.toxicon.2016.05.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxicon.2016.05.005","pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0041010116301349?via%3Dihub","source":{"id":"https://openalex.org/S42803210","display_name":"Toxicon","issn_l":"0041-0101","issn":["0041-0101","1879-3150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicon","raw_type":"journal-article"},{"id":"pmid:27179420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27179420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicon : official journal of the International Society on Toxinology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5178144","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5178144","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicon","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.toxicon.2016.05.005","doi":"https://doi.org/10.1016/j.toxicon.2016.05.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.toxicon.2016.05.005","pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0041010116301349?via%3Dihub","source":{"id":"https://openalex.org/S42803210","display_name":"Toxicon","issn_l":"0041-0101","issn":["0041-0101","1879-3150"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Toxicon","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G258636715","display_name":null,"funder_award_id":"#AC-0006","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G6303890544","display_name":"Collaborative Research:   ABI Development:   Development and Application of Graphical User Interfaces for System Building and Analysis of Membrane Simulations","funder_award_id":"1145987","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000911633","display_name":"Viper Resource Grant at Texas A&M University-Kingsville","funder_award_id":"P40OD010960","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320309170","display_name":"Florida State University","ror":"https://ror.org/05g3dte14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W610740297","https://openalex.org/W644821230","https://openalex.org/W1849631302","https://openalex.org/W1867204799","https://openalex.org/W1890259938","https://openalex.org/W1963545985","https://openalex.org/W1967868924","https://openalex.org/W1970362671","https://openalex.org/W1981733318","https://openalex.org/W1983996658","https://openalex.org/W1984028033","https://openalex.org/W1985423524","https://openalex.org/W1987435758","https://openalex.org/W1988946293","https://openalex.org/W1997134951","https://openalex.org/W2001354263","https://openalex.org/W2004217868","https://openalex.org/W2005960433","https://openalex.org/W2008964357","https://openalex.org/W2011758365","https://openalex.org/W2014928855","https://openalex.org/W2027259074","https://openalex.org/W2028205995","https://openalex.org/W2029136951","https://openalex.org/W2030404874","https://openalex.org/W2031215445","https://openalex.org/W2034137662","https://openalex.org/W2037177289","https://openalex.org/W2037717176","https://openalex.org/W2047919626","https://openalex.org/W2052509088","https://openalex.org/W2053209869","https://openalex.org/W2059003564","https://openalex.org/W2061200975","https://openalex.org/W2061320844","https://openalex.org/W2061466598","https://openalex.org/W2065142535","https://openalex.org/W2066352013","https://openalex.org/W2070553674","https://openalex.org/W2072880046","https://openalex.org/W2075049664","https://openalex.org/W2075941062","https://openalex.org/W2076274565","https://openalex.org/W2077905837","https://openalex.org/W2080409579","https://openalex.org/W2090117493","https://openalex.org/W2091370383","https://openalex.org/W2097790844","https://openalex.org/W2099925238","https://openalex.org/W2104511903","https://openalex.org/W2111598908","https://openalex.org/W2113111728","https://openalex.org/W2118303674","https://openalex.org/W2124140085","https://openalex.org/W2131395947","https://openalex.org/W2134634008","https://openalex.org/W2140146077","https://openalex.org/W2143162691","https://openalex.org/W2146419848","https://openalex.org/W2147914469","https://openalex.org/W2148187441","https://openalex.org/W2150146437","https://openalex.org/W2159783852","https://openalex.org/W2160146095","https://openalex.org/W2163393889","https://openalex.org/W2163916590","https://openalex.org/W2164539751","https://openalex.org/W2168535596","https://openalex.org/W2170508585","https://openalex.org/W2247009094","https://openalex.org/W2247952693","https://openalex.org/W2306228653","https://openalex.org/W2321769818","https://openalex.org/W2336791401","https://openalex.org/W4206631613","https://openalex.org/W4285719527","https://openalex.org/W4298009373","https://openalex.org/W6684594786","https://openalex.org/W6691280428"],"related_works":["https://openalex.org/W1985423524","https://openalex.org/W2608581538","https://openalex.org/W7151070023","https://openalex.org/W2010384525","https://openalex.org/W2795719805","https://openalex.org/W2140146077","https://openalex.org/W7204837410","https://openalex.org/W2793547367","https://openalex.org/W2023331728","https://openalex.org/W4408540867"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}