{"id":"https://openalex.org/W2357160271","doi":null,"title":"N-nitro-L-arginine methyl ester influence on aluminium toxicity in the brain.","display_name":"N-nitro-L-arginine methyl ester influence on aluminium toxicity in the brain.","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2357160271","mag":"2357160271","pmid":"https://pubmed.ncbi.nlm.nih.gov/22101955"},"language":"en","primary_location":{"id":"pmid:22101955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22101955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070421994","display_name":"Ivana D. Stevanovi\u0107","orcid":"https://orcid.org/0000-0002-4588-3447","observed_orcids":["https://orcid.org/0000-0002-4588-3447"]},"institutions":[{"id":"https://openalex.org/I1304155728","display_name":"Military Medical Academy","ror":"https://ror.org/04dt6a039","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I1304155728"]},{"id":"https://openalex.org/I4400008901","display_name":"Institute for Medical Research","ror":"https://ror.org/02vde2j43","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193","https://openalex.org/I4400008901"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Ivana D Stevanovi\u0107","raw_affiliation_strings":["Military Medical Academy, Institute for Medical Research, Crnotravska 17, 11 000 Belgrade, Serbia. ivanav13@yahoo.ca","Military Medical Academy, Institute for Medical Research, Crnotravska 17, 11 000 Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Medical Academy, Institute for Medical Research, Crnotravska 17, 11 000 Belgrade, Serbia. ivanav13@yahoo.ca","institution_ids":["https://openalex.org/I1304155728","https://openalex.org/I4400008901"]},{"raw_affiliation_string":"Military Medical Academy, Institute for Medical Research, Crnotravska 17, 11 000 Belgrade, Serbia","institution_ids":["https://openalex.org/I1304155728","https://openalex.org/I4400008901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086840755","display_name":"Marina Jovanovi\u0107","orcid":"https://orcid.org/0000-0001-9617-1151","observed_orcids":["https://orcid.org/0000-0001-9617-1151"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marina D Jovanovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028278181","display_name":"Miodrag J \u010coli\u0107","orcid":"https://orcid.org/0000-0002-6602-9493","observed_orcids":["https://orcid.org/0000-0002-6602-9493"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miodrag Coli\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111649991","display_name":"A Jelenkovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ankica Jelenkovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048517798","display_name":"Dubravko Bokonji\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dubravko Bokonji\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013162094","display_name":"Milica Ninkovi\u0107","orcid":"https://orcid.org/0000-0003-3303-9916","observed_orcids":["https://orcid.org/0000-0003-3303-9916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milica Ninkovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055538410","display_name":"Ivana R. Stojanovi\u0107","orcid":"https://orcid.org/0000-0002-8835-9370","observed_orcids":["https://orcid.org/0000-0002-8835-9370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivana Stojanovi\u0107","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7549,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.73498789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"49","issue":"3","first_page":"219","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9660000205039978},{"id":"https://openalex.org/keywords/aluminum-chloride","display_name":"aluminum chloride","score":0.5479999780654907},{"id":"https://openalex.org/keywords/aluminum-neurotoxicity","display_name":"aluminum neurotoxicity","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibition","display_name":"nitric oxide synthase inhibition","score":0.9259999990463257},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9369999766349792},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8880000114440918},{"id":"https://openalex.org/keywords/active-avoidance","display_name":"active avoidance","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.597000002861023},{"id":"https://openalex.org/keywords/basal-forebrain","display_name":"basal forebrain","score":0.9309999942779541},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8740000128746033},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8069999814033508},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6043261885643005},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6038866639137268},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5900672674179077},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.5824733972549438},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.5781716704368591},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5384049415588379},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.5273842811584473},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.5223392248153687},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4983823299407959},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4836522340774536},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.4716550409793854},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.47014978528022766},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.4695456922054291},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4616597294807434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3760877251625061},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3724173903465271},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34236451983451843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2988489866256714},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25492119789123535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23362794518470764},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.22953450679779053}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017607","descriptor_name":"Aluminum Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019331","descriptor_name":"NG-Nitroarginine Methyl Ester","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:22101955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22101955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},{"id":"mag:2357160271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22101955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W209077005","https://openalex.org/W1498891976","https://openalex.org/W1573348274","https://openalex.org/W1721708493","https://openalex.org/W1775749144","https://openalex.org/W1962019830","https://openalex.org/W1964803638","https://openalex.org/W1967944001","https://openalex.org/W1971884099","https://openalex.org/W1983218156","https://openalex.org/W1985122965","https://openalex.org/W1989202389","https://openalex.org/W2003335896","https://openalex.org/W2008759529","https://openalex.org/W2011808912","https://openalex.org/W2018206432","https://openalex.org/W2022389180","https://openalex.org/W2025577312","https://openalex.org/W2039235928","https://openalex.org/W2045955332","https://openalex.org/W2048553024","https://openalex.org/W2054149684","https://openalex.org/W2056204707","https://openalex.org/W2060450776","https://openalex.org/W2078069511","https://openalex.org/W2090316173","https://openalex.org/W2091448266","https://openalex.org/W2093477129","https://openalex.org/W2094653426","https://openalex.org/W2101923590","https://openalex.org/W2164034701","https://openalex.org/W2165376987","https://openalex.org/W2419484586"],"related_works":["https://openalex.org/W1983026143","https://openalex.org/W7097078043","https://openalex.org/W2097020897","https://openalex.org/W7018760917","https://openalex.org/W2419484586","https://openalex.org/W2022389180","https://openalex.org/W2165376987","https://openalex.org/W4229445955","https://openalex.org/W7009390218","https://openalex.org/W2043426936"],"abstract_inverted_index":{"We":[0,97],"investigated":[1],"the":[2,41,58,63,91],"influence":[3],"of":[4,60,117,124],"a":[5,137,146],"non-specific":[6],"nitric":[7],"oxide":[8],"synthase":[9],"(NOS)":[10],"inhibitor,":[11],"N-nitro-L-arginine":[12],"methyl":[13],"ester":[14],"(L-NAME),":[15],"on":[16,130],"brain":[17],"nitrite":[18],"concentration":[19],"and":[20,37,43,45,66,69,120,126,136],"acetylcholine":[21],"esterase":[22],"activity":[23],"in":[24,54,62,150],"AlCl3-treated":[25],"Wistar":[26],"rats.":[27],"Animals":[28],"were":[29,48],"killed":[30],"10":[31],"min,":[32],"three":[33,35,118],"hours,":[34],"days":[36,39,119],"30":[38,121],"after":[40,83,114],"treatment":[42],"hippocampus":[44],"basal":[46],"forebrain":[47],"removed.":[49],"The":[50],"biochemical":[51],"changes":[52,104],"observed":[53],"neuronal":[55],"tissues":[56],"show":[57],"involvement":[59],"NO":[61],"AlCl3":[64,84],"toxicity":[65],"cholinergic":[67],"neurotransmission,":[68],"that":[70],"L-NAME":[71,89,112],"may":[72],"have":[73],"potential":[74],"neuroprotective":[75],"effects.":[76],"Active":[77],"avoidance":[78],"learning":[79],"was":[80],"significantly":[81],"impaired":[82],"application,":[85],"while":[86],"pretreatment":[87],"with":[88],"prevented":[90],"behavioural":[92],"deficits":[93],"caused":[94],"by":[95,106],"AlCl3.":[96],"also":[98],"applied":[99],"immunohistochemical":[100],"techniques":[101],"to":[102,154],"identify":[103],"induced":[105],"AlCl3,":[107],"L-NAME+AlCl3,":[108],"as":[109,111],"well":[110],"injections":[113],"survival":[115],"periods":[116],"days.":[122],"Immunoreactivity":[123],"astrocytes":[125],"phagocytic":[127],"microglia":[128],"based":[129],"glial":[131],"fibrillary":[132],"acidic":[133],"protein":[134],"(GFAP)":[135],"useful":[138],"marker":[139],"for":[140],"rat":[141],"macrophages":[142],"(ED1),":[143],"respectively,":[144],"revealed":[145],"greater":[147],"inflammatory":[148],"response":[149],"AlCl3-injected":[151],"animals":[152],"compared":[153],"controls.":[155]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}