{"id":"https://openalex.org/W2356490264","doi":null,"title":"Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus.","display_name":"Ischemia-induced release of cytochrome c from mitochondria and up-regulation of Bcl-2 expression in rat hippocampus.","publication_year":2004,"publication_date":"2004-04-25","ids":{"openalex":"https://openalex.org/W2356490264","mag":"2356490264","pmid":"https://pubmed.ncbi.nlm.nih.gov/15127122"},"language":"en","primary_location":{"id":"pmid:15127122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15127122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chun-Yi Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Yi Zhang","raw_affiliation_strings":["Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, Xuzhou 221001, China","institution_ids":["https://openalex.org/I177388780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079033540","display_name":"Wanhua Shen","orcid":"https://orcid.org/0000-0002-5178-9561","observed_orcids":["https://orcid.org/0000-0002-5178-9561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wan-Hua Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101487989","display_name":"Guangyi Zhang","orcid":"https://orcid.org/0000-0003-2356-0687","observed_orcids":["https://orcid.org/0000-0003-2356-0687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guang-Yi Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"56","issue":"2","first_page":"147","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.6669999957084656},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.656000018119812},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.859000027179718},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.7820000052452087},{"id":"https://openalex.org/keywords/ketamine","display_name":"ketamine","score":0.824999988079071},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-c-oxidase","display_name":"cytochrome c oxidase","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8349999785423279}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7080245018005371},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6458291411399841},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.6216541528701782},{"id":"https://openalex.org/C123249941","wikidata":"https://www.wikidata.org/wiki/Q306116","display_name":"Cytochrome c oxidase","level":3,"score":0.594252347946167},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5738381743431091},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.4401649236679077},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.42657470703125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42082318663597107},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39173540472984314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37214839458465576},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3494250178337097},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3361111879348755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2953055500984192},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18400627374649048},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07392185926437378}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009543","descriptor_name":"Nifedipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D045304","descriptor_name":"Cytochromes c","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:15127122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15127122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sheng li xue bao : [Acta physiologica Sinica]","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W133907179","https://openalex.org/W1044773344","https://openalex.org/W1775749144","https://openalex.org/W1847469566","https://openalex.org/W1979995768","https://openalex.org/W2003290562","https://openalex.org/W2008895830","https://openalex.org/W2015591213","https://openalex.org/W2016575029","https://openalex.org/W2020296531","https://openalex.org/W2026235040","https://openalex.org/W2046170990","https://openalex.org/W2051063352","https://openalex.org/W2056326326","https://openalex.org/W2059006262","https://openalex.org/W2063568808","https://openalex.org/W2074421152","https://openalex.org/W2108131089","https://openalex.org/W2119683782","https://openalex.org/W2130866079","https://openalex.org/W2135725455","https://openalex.org/W2139290875","https://openalex.org/W2144701362","https://openalex.org/W2149967205","https://openalex.org/W2170407368","https://openalex.org/W2409339579"],"related_works":["https://openalex.org/W2046996594","https://openalex.org/W2026235040","https://openalex.org/W2385570132","https://openalex.org/W2006530193","https://openalex.org/W4322703187","https://openalex.org/W2488964765","https://openalex.org/W2014486362","https://openalex.org/W1966403764","https://openalex.org/W1690631198","https://openalex.org/W2379632331"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,8,18,66,90,138,148],"effects":[3],"of":[4,10,20,93,140,150],"different":[5],"antagonists":[6],"on":[7],"release":[9,139,165],"cytochrome":[11,33,55,94,106,141],"c":[12,34,56,107,142,164],"from":[13,143],"mitochondria":[14,23,109,144],"to":[15,132,145,175],"cytosol":[16,146],"and":[17,32,105,147],"expression":[19,35,70],"Bcl-2":[21,31,69,104,151,170],"in":[22,24,59,65,89,103,108],"rat":[25],"hippocampus":[26],"after":[27,50,77],"ischemia,":[28],"we":[29],"examined":[30],"by":[36,112,155],"immunoblotting":[37],"using":[38],"4-vessel":[39],"occlusion":[40],"(4-VO)":[41],"as":[42],"brain":[43,161],"ischemia":[44],"model.":[45],"The":[46,101,134],"results":[47,135],"showed":[48],"that":[49,137],"24":[51],"h":[52,79],"ischemia/reperfusion":[53],"(I/R)":[54],"decreased":[57],"markedly":[58],"mitochondria,":[60],"which":[61],"was":[62,71],"correspondingly":[63],"increased":[64],"cytosolic":[67],"fraction.":[68],"time-dependent,":[72],"reaching":[73],"its":[74],"peak":[75],"level":[76],"6":[78],"I/R.":[80],"In":[81],"all":[82],"those":[83],"samples,":[84],"there":[85],"were":[86,110],"no":[87],"alterations":[88],"subcellular":[91],"distribution":[92],"oxidase,":[95],"a":[96],"mitochondrial":[97],"respiratory":[98],"chain":[99],"protein.":[100],"decreases":[102],"restored":[111],"pretreatment":[113],"with":[114],"non-competitive":[115],"NMDA":[116,156],"receptor":[117],"antagonist":[118,126],"ketamine":[119],"or":[120,158],"L-type":[121],"voltage-gated":[122],"Ca(2+)":[123],"channel":[124],"(L-VGCC)":[125],"nifedipine":[127],"at":[128],"20":[129],"min":[130],"prior":[131],"ischemia.":[133,162],"demonstrate":[136],"up-regulation":[149,171],"are":[152],"possibly":[153],"mediated":[154],"receptors":[157],"L-VGCC":[159],"following":[160],"Cytochrome":[163],"may":[166,172],"be":[167,173],"injurious":[168],"while":[169],"protective":[174],"ischemic":[176],"hippocampus.":[177]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
