{"id":"https://openalex.org/W235533997","doi":null,"title":"Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation.","display_name":"Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation.","publication_year":2009,"publication_date":"2009-10-05","ids":{"openalex":"https://openalex.org/W235533997","mag":"235533997","pmid":"https://pubmed.ncbi.nlm.nih.gov/20079138"},"language":"en","primary_location":{"id":"pmid:20079138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20079138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101614054","display_name":"Zhijie He","orcid":"https://orcid.org/0000-0003-1712-1733","observed_orcids":["https://orcid.org/0000-0003-1712-1733","https://orcid.org/0009-0004-7092-7079"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-jie He","raw_affiliation_strings":["Department of ICU, the Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510120, China. hezhijie2004@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of ICU, the Second Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510120, China. hezhijie2004@126.com","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101853931","display_name":"Zitong Huang","orcid":"https://orcid.org/0000-0001-7936-4963","observed_orcids":["https://orcid.org/0000-0001-7936-4963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zi-tong Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xiao-tong Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-tong Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101727450","display_name":"Zijun Zou","orcid":"https://orcid.org/0000-0001-8467-0236","observed_orcids":["https://orcid.org/0000-0001-8467-0236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zi-jun Zou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8906,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.92601461,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"122","issue":"19","first_page":"2346","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9779999852180481},{"id":"https://openalex.org/keywords/sb-3ct","display_name":"SB-3CT","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cardiopulmonary-resuscitation","display_name":"cardiopulmonary resuscitation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/global-cerebral-ischemia-reperfusion-injury","display_name":"global cerebral ischemia-reperfusion injury","score":0.8640000224113464},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cerebral-edema","display_name":"cerebral edema","score":0.703000009059906},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7689999938011169},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.7210000157356262},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cardiac-arrest","display_name":"cardiac arrest","score":0.6909999847412109},{"id":"https://openalex.org/keywords/brain-ultrastructure","display_name":"brain ultrastructure","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.84024977684021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7876731157302856},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6444538831710815},{"id":"https://openalex.org/C2777055891","wikidata":"https://www.wikidata.org/wiki/Q185325","display_name":"Cardiopulmonary resuscitation","level":3,"score":0.6384232640266418},{"id":"https://openalex.org/C2777649898","wikidata":"https://www.wikidata.org/wiki/Q5415983","display_name":"Evans Blue","level":2,"score":0.5693057775497437},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5206093788146973},{"id":"https://openalex.org/C2775997469","wikidata":"https://www.wikidata.org/wiki/Q18029196","display_name":"MMP9","level":4,"score":0.5069387555122375},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5037469267845154},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.4341077506542206},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.4307454228401184},{"id":"https://openalex.org/C2776452961","wikidata":"https://www.wikidata.org/wiki/Q1940733","display_name":"Mean arterial pressure","level":4,"score":0.42574024200439453},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27152231335639954},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2660057842731476},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2452380359172821},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.16339382529258728},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.1124599277973175},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07769706845283508},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016887","descriptor_name":"Cardiopulmonary Resuscitation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:20079138","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20079138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical journal","raw_type":"Journal Article"},{"id":"mag:235533997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20079138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:3142393405","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/85656X/200919/32512207.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541197","display_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1970341483","https://openalex.org/W1973613680","https://openalex.org/W1998557118","https://openalex.org/W2005491839","https://openalex.org/W2008996296","https://openalex.org/W2014662852","https://openalex.org/W2034804703","https://openalex.org/W2034882426","https://openalex.org/W2043276957","https://openalex.org/W2048047884","https://openalex.org/W2061173173","https://openalex.org/W2092658609","https://openalex.org/W2104740550","https://openalex.org/W2123648780","https://openalex.org/W2132401640","https://openalex.org/W2135423586","https://openalex.org/W2166860948","https://openalex.org/W2168824255","https://openalex.org/W2169043018","https://openalex.org/W2398222113"],"related_works":["https://openalex.org/W21718459","https://openalex.org/W3030998889","https://openalex.org/W2359469333","https://openalex.org/W2254032589","https://openalex.org/W3028859739","https://openalex.org/W2391305259","https://openalex.org/W7007272585","https://openalex.org/W1181397514","https://openalex.org/W2222821926","https://openalex.org/W3196829745"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuroprotective":[1],"strategies":[2],"following":[3],"cardiopulmonary":[4],"resuscitation":[5,78,84,101,104,115,150,213,261,274,291],"(CPR)":[6],"are":[7],"an":[8],"important":[9],"focus":[10],"in":[11,29,40,259,272,289,314,337],"emergency":[12],"and":[13,52,67,83,96,103,133,164,176,197,201,222,231,239,302,311,326],"critical":[14],"care":[15],"medicine.":[16],"Matrix":[17],"metalloproteinases":[18],"(MMPs),":[19],"especially":[20],"MMP9":[21,186,188,220,300,330],"attracted":[22],"much":[23],"attention":[24],"because":[25],"of":[26,47,130,158,185,219,299,322],"its":[27],"function":[28],"focal":[30,36],"brain":[31,50,203,216,316,339],"ischemia/reperfusion":[32],"injury.":[33,340],"In":[34,113,211],"the":[35,45,100,114,202,212,249,260,273,279,290,323],"cerebral":[37,59],"ischemia":[38],"model":[39],"rats,":[41],"SB-3CT":[42,118],"can":[43],"suppress":[44],"expression":[46,184,218,331],"MMP9,":[48],"relieving":[49],"edema,":[51],"there":[53],"was":[54,119,199,332],"no":[55],"studies":[56],"on":[57],"global":[58],"ischemia-reperfusion":[60],"injury":[61],"after":[62,122,169,244,318],"CPR.":[63],"METHODS:":[64],"One":[65],"hundred":[66],"twenty":[68],"rats":[69,92,161],"were":[70,93,162,166,233,270,286],"randomly":[71],"assigned":[72],"to":[73],"sham-operated":[74,250,280],"(n":[75,80,86,179],"=":[76,81,87,140,180],"40),":[77,82],"treatment":[79,102,116,275],"control":[85,105,151,214,262,292],"40)":[88],"groups.":[89],"Sham-operated":[90],"group":[91,152,251,276,281,293],"anesthetized":[94],"only":[95],"intubated":[97],"tracheally,":[98],"while":[99],"groups":[106],"also":[107,153,257],"received":[108],"cardiac":[109],"arrest":[110],"by":[111],"asphyxiation.":[112],"group,":[117,215],"injected":[120],"intraperitoneally":[121],"restoring":[123],"spontaneous":[124],"circulation":[125],"(ROSC),":[126],"defined":[127],"as":[128],"restoration":[129],"supraventricular":[131],"rhythm":[132],"mean":[134],"arterial":[135],"pressure":[136],"(MAP)":[137],">":[138],"or":[139],"60":[141],"mm":[142],"Hg":[143],"for":[144],"more":[145],"than":[146,288],"5":[147],"minutes.":[148],"The":[149,160],"implemented":[154],"ROSC":[155],"without":[156],"injection":[157],"SB-3CT.":[159],"executed":[163],"samples":[165],"taken":[167],"immediately":[168],"death,":[170],"then":[171],"at":[172,236,241],"3,":[173],"9,":[174],"24,":[175],"48":[177],"hours":[178,243],"8).":[181],"Brain":[182],"tissue":[183,204,217,317],"protein,":[187],"mRNA,":[189,223,303],"water":[190,224,304],"content,":[191,194,225,228,305,308],"Evans":[192,226,306],"blue":[193,227,307],"TNF-alpha,":[195,229,309],"IL-1,":[196,230,310],"IL-6":[198,232,312],"measured,":[200],"ultramicrostructure":[205,256],"studied":[206],"with":[207,248,278,334],"electron":[208],"microscopy.":[209],"RESULTS:":[210],"protein":[221,301],"significantly":[234],"elevated":[235],"3":[237],"hours,":[238],"peaked":[240],"24":[242],"resuscitation,":[245],"when":[246],"compared":[247,277],"(P":[252,282,294],"<":[253,283,295],"0.05).":[254,296],"Tissue":[255],"changed":[258],"group.":[263],"By":[264],"contrast,":[265],"although":[266],"all":[267],"these":[268],"indexes":[269],"increased":[271,313],"0.05),":[284],"they":[285],"lower":[287],"CONCLUSIONS:":[297],"Expression":[298],"rat":[315],"CPR,":[319],"indicating":[320],"disruption":[321],"blood-brain":[324],"barrier":[325],"excess":[327],"inflammatory":[328],"reaction.":[329],"reduced":[333,338],"SB-3CT,":[335],"resulting":[336]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}