{"id":"https://openalex.org/W2354945339","doi":"https://doi.org/10.1002/biot.201600013","title":"Co\u2010culture engineering for microbial biosynthesis of 3\u2010amino\u2010benzoic acid in Escherichia coli","display_name":"Co\u2010culture engineering for microbial biosynthesis of 3\u2010amino\u2010benzoic acid in Escherichia coli","publication_year":2016,"publication_date":"2016-05-11","ids":{"openalex":"https://openalex.org/W2354945339","doi":"https://doi.org/10.1002/biot.201600013","mag":"2354945339","pmid":"https://pubmed.ncbi.nlm.nih.gov/27168529"},"language":"en","primary_location":{"id":"doi:10.1002/biot.201600013","doi":"https://doi.org/10.1002/biot.201600013","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201600013","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.7282/t398893r","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Haoran Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Haoran Zhang","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA","Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gregory Stephanopoulos","raw_affiliation_strings":["Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biochemical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ, USA","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009763658"],"corresponding_institution_ids":["https://openalex.org/I102322142","https://openalex.org/I63966007"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":3.9863,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.94821743,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"11","issue":"7","first_page":"981","last_page":"987"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9440000057220459},{"id":"https://openalex.org/keywords/microbial-production","display_name":"microbial production","score":0.9160000085830688},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"metabolic engineering","score":0.625},{"id":"https://openalex.org/keywords/biomanufacturing","display_name":"bioproduction","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8727952241897583},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.8153667449951172},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.8068808317184448},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5912439227104187},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.578669548034668},{"id":"https://openalex.org/C2778844314","wikidata":"https://www.wikidata.org/wiki/Q191700","display_name":"Benzoic acid","level":2,"score":0.5742299556732178},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5718865990638733},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5632095336914062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4510178565979004},{"id":"https://openalex.org/C2779039970","wikidata":"https://www.wikidata.org/wiki/Q3610387","display_name":"Industrial microbiology","level":3,"score":0.43646275997161865},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4237425923347473},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3668389320373535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25641900300979614},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.2561492919921875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.08834215998649597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05887335538864136},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053898","descriptor_name":"Biosynthetic Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D062368","descriptor_name":"meta-Aminobenzoates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/biot.201600013","doi":"https://doi.org/10.1002/biot.201600013","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.201600013","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:27168529","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27168529","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology journal","raw_type":"Journal Article"},{"id":"pmh:oai:alma.01RUT_INST:11643407280004646","doi":null,"is_oa":false,"landing_page_url":"https://scholarship.libraries.rutgers.edu/esploro/outputs/acceptedManuscript/Co-culture-engineering-for-microbial-biosynthesis-of/991031549906304646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:osti.gov:1400761","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/1400761","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.7282/t398893r","doi":"https://doi.org/10.7282/t398893r","is_oa":true,"landing_page_url":"https://doi.org/10.7282/t398893r","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.7282/t398893r","doi":"https://doi.org/10.7282/t398893r","is_oa":true,"landing_page_url":"https://doi.org/10.7282/t398893r","pdf_url":null,"source":{"id":"https://openalex.org/S4306401388","display_name":"Rutgers University Community Repository (Rutgers University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102322142","host_organization_name":"Rutgers, The State University of New Jersey","host_organization_lineage":["https://openalex.org/I102322142"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4409610238","display_name":"NEW; TITLE: DYNAMIC METABOLIC MODEL BUILDING BASED ON ENSEMBLE MODELING APPROACH; PI: JAMES LIAO","funder_award_id":"DESC0006698","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332322","display_name":"Institute on Ethnicity, Culture, and the Modern Experience, Rutgers University","ror":"https://ror.org/05vt9qd57"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W39180896","https://openalex.org/W1518596802","https://openalex.org/W1958250075","https://openalex.org/W1966949519","https://openalex.org/W1975053285","https://openalex.org/W1983374959","https://openalex.org/W1989316655","https://openalex.org/W2018077728","https://openalex.org/W2022720960","https://openalex.org/W2034233874","https://openalex.org/W2045517985","https://openalex.org/W2062609004","https://openalex.org/W2071348814","https://openalex.org/W2106857639","https://openalex.org/W2127543426","https://openalex.org/W2131164817","https://openalex.org/W2134783465","https://openalex.org/W2158197738","https://openalex.org/W2162780952","https://openalex.org/W2165500111","https://openalex.org/W2167153673"],"related_works":["https://openalex.org/W2935524918","https://openalex.org/W1958250075","https://openalex.org/W7117296611","https://openalex.org/W7134840933","https://openalex.org/W6888038641","https://openalex.org/W3037296410","https://openalex.org/W4409527180","https://openalex.org/W2883979689","https://openalex.org/W3027966366","https://openalex.org/W4221042714"],"abstract_inverted_index":{"3-amino-benzoic":[0],"acid":[1],"(3AB)":[2],"is":[3],"an":[4,69,75,89,93],"important":[5,16],"building":[6],"block":[7],"molecule":[8],"for":[9,36,126],"production":[10,40,63,128,139],"of":[11,15,64,112,150,157,176],"a":[12,32,104,110,168],"wide":[13],"range":[14],"compounds":[17],"such":[18],"as":[19],"natural":[20],"products":[21],"with":[22],"various":[23],"biological":[24],"activities.":[25],"In":[26,68],"the":[27,42,47,55,62,73,85,97,120,145,151,173],"present":[28],"study,":[29],"we":[30],"established":[31],"microbial":[33],"biosynthetic":[34,50,86,99,122],"system":[35,80,133,153],"de":[37],"novo":[38],"3AB":[39,49,138],"from":[41],"simple":[43],"substrate":[44],"glucose.":[45],"First,":[46],"active":[48],"pathway":[51,87],"was":[52,81,101,134],"reconstituted":[53],"in":[54,61,103,155,172],"bacterium":[56],"Escherichia":[57],"coli,":[58],"which":[59],"resulted":[60,154],"1.5":[65],"mg/L":[66,159],"3AB.":[67,160],"effort":[70],"to":[71,83,118,136,144],"improve":[72,137],"production,":[74],"E.":[76,106,113],"coli-E.":[77],"coli":[78,107,114],"co-culture":[79,132,152,164],"engineered":[82,117],"modularize":[84],"between":[88],"upstream":[90,98],"strain":[91],"and":[92,124],"downstream":[94,121],"strain.":[95],"Specifically,":[96],"module":[100,123],"contained":[102],"fixed":[105],"strain,":[108],"whereas":[109],"series":[111],"strains":[115],"were":[116],"accommodate":[119],"screened":[125],"optimal":[127],"performance.":[129],"The":[130],"best":[131],"found":[135],"by":[140],"15":[141],"fold,":[142],"compared":[143],"mono-culture":[146],"approach.":[147],"Further":[148],"engineering":[149,165],"biosynthesis":[156],"48":[158],"Our":[161],"results":[162],"demonstrate":[163],"can":[166],"be":[167],"powerful":[169],"new":[170],"approach":[171],"broad":[174],"field":[175],"metabolic":[177],"engineering.":[178]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}