{"id":"https://openalex.org/W2354892273","doi":null,"title":"Bimatoprost-induced periocular skin hyperpigmentation: Histopathological study","display_name":"Bimatoprost-induced periocular skin hyperpigmentation: Histopathological study","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2354892273","mag":"2354892273"},"language":"en","primary_location":{"id":"mag:2354892273","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-SJXY200603032.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764606992","display_name":"Digest of the World Core Medical Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Digest of the World Core Medical Journals","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"W. Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"W. Taylor","raw_affiliation_strings":["St, Chicago, IL 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St, Chicago, IL 60612, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.20227694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.011800000444054604,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bimatoprost","display_name":"bimatoprost","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eyelid","display_name":"eyelid","score":0.6019999980926514},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.8410000205039978},{"id":"https://openalex.org/keywords/melanin-granules","display_name":"melanin granules","score":0.8930000066757202},{"id":"https://openalex.org/keywords/melanosomes","display_name":"melanosomes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.734000027179718},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/s100-protein","display_name":"S-100 protein","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.6869999766349792},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.9179999828338623},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7379999756813049},{"id":"https://openalex.org/keywords/prostamide","display_name":"prostamide","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2777336333","wikidata":"https://www.wikidata.org/wiki/Q2393348","display_name":"Bimatoprost","level":4,"score":0.907450258731842},{"id":"https://openalex.org/C94435474","wikidata":"https://www.wikidata.org/wiki/Q1065756","display_name":"Melanosome","level":3,"score":0.8466038703918457},{"id":"https://openalex.org/C2776728111","wikidata":"https://www.wikidata.org/wiki/Q1641068","display_name":"Hyperpigmentation","level":2,"score":0.6904451251029968},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.6716148853302002},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.563109815120697},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.5417194962501526},{"id":"https://openalex.org/C14764753","wikidata":"https://www.wikidata.org/wiki/Q905225","display_name":"Bright-field microscopy","level":3,"score":0.48427218198776245},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.45437145233154297},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41436487436294556},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.4134847819805145},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3437017798423767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3178088665008545},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2567453682422638},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.19904711842536926},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.14553824067115784},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.13026544451713562},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.0638694167137146},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2354892273","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTotal-SJXY200603032.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764606992","display_name":"Digest of the World Core Medical Journals","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Digest of the World Core Medical Journals","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988540100","https://openalex.org/W2170344532","https://openalex.org/W1983179942","https://openalex.org/W2084633653","https://openalex.org/W2019253320","https://openalex.org/W6902260786","https://openalex.org/W1965356910","https://openalex.org/W4389998065","https://openalex.org/W1848776477","https://openalex.org/W2075517925"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"investigate":[2],"light":[3,25,66],"microscopic":[4],"and":[5,19,27,42,57,93,138],"ultrastructural":[6],"changes":[7],"in":[8,71,79,97,128,136,146,152,177],"bimatoprost-induced":[9],"skin":[10],"hyperpigmentation.":[11],"Methods:":[12],"Eyelid":[13],"biopsy":[14],"specimens":[15,113,149,179],"from":[16],"bimatoprost-treated":[17,81,137,148],"patients":[18],"matched":[20],"controls":[21],"were":[22,37,44,62,126,134,150,181],"examined":[23],"by":[24,162],"microscopy":[26,84],"transmission":[28],"electron":[29,47],"microscopy.":[30],"Using":[31],"an":[32],"image":[33],"analyzer,":[34],"melanin":[35,75],"granules":[36,76],"counted":[38,45],"on":[39,46],"Fontana-Masson-stained":[40],"sections,":[41],"melanosomes":[43,96],"micrographs.":[48],"Immunohistochemical":[49],"analysis":[50],"was":[51,77,167],"performed":[52],"with":[53,88,104,119],"antibodies":[54],"against":[55],"S100":[56],"CD3.":[58],"Positively":[59],"labeled":[60],"cells":[61,145],"counted.":[63],"Results:":[64],"By":[65],"microscopy,":[67],"a":[68],"marked":[69],"increase":[70],"the":[72,80,108,111,147,178],"number":[73],"of":[74,100,110,122,170],"noted":[78,151],"specimens.":[82,106,130,140],"Electron":[83],"demonstrated":[85],"dermal":[86],"melanocytes":[87,125,133],"prominent":[89],"rough":[90],"endoplasmic":[91],"reticulum":[92],"abundant":[94,115],"normal-sized":[95],"different":[98],"stages":[99],"maturation":[101],"as":[102],"compared":[103,118],"control":[105,139],"Furthermore,":[107],"keratinocytes":[109],"bimatoprosttreated":[112],"showed":[114],"mature":[116],"melanosomeswhen":[117],"controls.":[120],"Also":[121],"note,":[123],"atypical":[124],"absent":[127],"both":[129,153],"The":[131],"S100-positive":[132],"comparable":[135],"Few":[141],"CD3-and":[142],"CD68-positi":[143],"ve":[144],"groups.":[154],"Conclu":[155],"sion:":[156],"Bimatoprost-induced":[157],"periocular":[158],"hyperpigmentation":[159],"is":[160],"caused":[161],"increa":[163],"sed":[164],"melanogenesis.":[165],"There":[166],"no":[168],"evidence":[169],"melanocyte":[171],"proliferation":[172],"or":[173],"prostagl":[174],"andin-induced":[175],"inflammation":[176],"that":[180],"examined.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}