{"id":"https://openalex.org/W23547296","doi":null,"title":"Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes.","display_name":"Exome sequencing on malignant meningiomas identified mutations in neurofibromatosis type 2 (NF2) and meningioma 1 (MN1) genes.","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W23547296","mag":"23547296","pmid":"https://pubmed.ncbi.nlm.nih.gov/25549701","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720499"},"language":"en","primary_location":{"id":"pmid:25549701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25549701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720499","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100437278","display_name":"Xu Zhang","orcid":"https://orcid.org/0000-0002-9784-0481","observed_orcids":["https://orcid.org/0000-0002-9784-0481"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zhang","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, Guangdong 510641, China and BGI Diagnosis, Tianjin, Tianjin 300308, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, Guangdong 510641, China and BGI Diagnosis, Tianjin, Tianjin 300308, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088968868","display_name":"Haiying Jia","orcid":"https://orcid.org/0000-0002-3051-6783","observed_orcids":["https://orcid.org/0000-0002-3051-6783"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210162753","display_name":"First Affiliated Hospital of Jinan University","ror":"https://ror.org/05d5vvz89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162753"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Haiying Jia","raw_affiliation_strings":["Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA and The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA and The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I159948400","https://openalex.org/I4210162753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090998485","display_name":"Yao Lu","orcid":"https://orcid.org/0000-0002-2898-9813","observed_orcids":["https://orcid.org/0000-0002-2898-9813"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Lu","raw_affiliation_strings":["School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, Guangdong 510641, China and BGI Tech Solutions, Shenzhen, Guangdong 518083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, Guangdong 510641, China and BGI Tech Solutions, Shenzhen, Guangdong 518083, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112183195","display_name":"Chengliang Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chengliang Dong","raw_affiliation_strings":["Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112127640","display_name":"Jinghui Hou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinghui Hou","raw_affiliation_strings":["Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510632, China","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401124","display_name":"Zheng Wang","orcid":"https://orcid.org/0000-0002-8388-6139","observed_orcids":["https://orcid.org/0000-0002-8388-6139","https://orcid.org/0000-0002-8835-9960"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Wang","raw_affiliation_strings":["Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100431215","display_name":"Feng Wang","orcid":"https://orcid.org/0000-0002-2441-7543","observed_orcids":["https://orcid.org/0000-0002-2441-7543"]},"institutions":[{"id":"https://openalex.org/I100135526","display_name":"BGI Group (China)","ror":"https://ror.org/045pn2j94","country_code":"CN","type":"company","lineage":["https://openalex.org/I100135526"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Wang","raw_affiliation_strings":["BGI Tech Solutions, Shenzhen, Guangdong 518083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI Tech Solutions, Shenzhen, Guangdong 518083, China","institution_ids":["https://openalex.org/I100135526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100538984","display_name":"Hongbin Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100135526","display_name":"BGI Group (China)","ror":"https://ror.org/045pn2j94","country_code":"CN","type":"company","lineage":["https://openalex.org/I100135526"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongbin Zhong","raw_affiliation_strings":["BGI Tech Solutions, Shenzhen, Guangdong 518083, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BGI Tech Solutions, Shenzhen, Guangdong 518083, China","institution_ids":["https://openalex.org/I100135526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403087","display_name":"Lin Wang","orcid":"https://orcid.org/0000-0001-5716-6587","observed_orcids":["https://orcid.org/0000-0001-5716-6587","https://orcid.org/0000-0001-5689-5040"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Wang","raw_affiliation_strings":["Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Zilkha Neurogenetic Institute and Department of Psychiatry, University of Southern California, Los Angeles, CA 90089, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zilkha Neurogenetic Institute and Department of Psychiatry, University of Southern California, Los Angeles, CA 90089, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2669,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.86671784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"101","first_page":"301","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaplastic-meningioma","display_name":"malignant meningioma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neurofibromatosis-type-2","display_name":"neurofibromatosis type 2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/mn1","display_name":"MN1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8489999771118164},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/arid1b","display_name":"ARID1B","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sema4d","display_name":"Sema4D","score":0.9990000128746033},{"id":"https://openalex.org/keywords/muc2","display_name":"MUC2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/private-mutations","display_name":"private mutations","score":0.4830000102519989},{"id":"https://openalex.org/keywords/candidate-genes","display_name":"candidate genes","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.8175077438354492},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.7770915031433105},{"id":"https://openalex.org/C2778679214","wikidata":"https://www.wikidata.org/wiki/Q1935832","display_name":"Neurofibromatosis type 2","level":3,"score":0.7168830037117004},{"id":"https://openalex.org/C10590036","wikidata":"https://www.wikidata.org/wiki/Q417664","display_name":"Exome","level":5,"score":0.6465151309967041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5936017036437988},{"id":"https://openalex.org/C2779160599","wikidata":"https://www.wikidata.org/wiki/Q369157","display_name":"Meningioma","level":2,"score":0.5917556881904602},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.5736429691314697},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5356793999671936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.511034369468689},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.48999539017677307},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47585031390190125},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.47030752897262573},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4578058421611786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39799028635025024},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19672927260398865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1786586046218872}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008577","descriptor_name":"Meningeal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016515","descriptor_name":"Genes, Neurofibromatosis 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059472","descriptor_name":"Exome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:25549701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25549701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Discovery medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4720499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},{"id":"mag:23547296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25549701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4720499","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720499","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Discov Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.7599999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6209933853","display_name":"Integrated Variation Detection Annotation and Analysis","funder_award_id":"R01HG006465","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1560814177","https://openalex.org/W1601233953","https://openalex.org/W1893588436","https://openalex.org/W1967937896","https://openalex.org/W1968560937","https://openalex.org/W1979068808","https://openalex.org/W1980740976","https://openalex.org/W1982203820","https://openalex.org/W1983904019","https://openalex.org/W1984053802","https://openalex.org/W1984068087","https://openalex.org/W1989773675","https://openalex.org/W1990028805","https://openalex.org/W1995616389","https://openalex.org/W2000292756","https://openalex.org/W2000381516","https://openalex.org/W2004853526","https://openalex.org/W2009669451","https://openalex.org/W2016090899","https://openalex.org/W2021392815","https://openalex.org/W2022093187","https://openalex.org/W2041456436","https://openalex.org/W2047265377","https://openalex.org/W2053642340","https://openalex.org/W2059145105","https://openalex.org/W2092864149","https://openalex.org/W2094523058","https://openalex.org/W2102140136","https://openalex.org/W2102730296","https://openalex.org/W2103441770","https://openalex.org/W2108234281","https://openalex.org/W2112612051","https://openalex.org/W2117197109","https://openalex.org/W2119180969","https://openalex.org/W2123783570","https://openalex.org/W2141759541","https://openalex.org/W2144179468","https://openalex.org/W2145187337","https://openalex.org/W2148977460","https://openalex.org/W2154170543","https://openalex.org/W2155943701","https://openalex.org/W2158217645","https://openalex.org/W2166299071","https://openalex.org/W2166693354","https://openalex.org/W2338112712","https://openalex.org/W4211028957"],"related_works":["https://openalex.org/W2021531214","https://openalex.org/W7100875199","https://openalex.org/W2688701451","https://openalex.org/W2069290266","https://openalex.org/W4410396303","https://openalex.org/W3217378641","https://openalex.org/W2943529051","https://openalex.org/W3023257897","https://openalex.org/W4206228219","https://openalex.org/W2090303627"],"abstract_inverted_index":{"BACKGROUND:":[0],"Meningiomas":[1],"are":[2,15,26,29],"tumors":[3,20],"originating":[4],"from":[5],"the":[6,10,22,88,218,230,236],"membranous":[7],"layers":[8],"surrounding":[9],"central":[11],"nervous":[12],"system,":[13],"and":[14,28,40,53,106,115,134,156,171,181,200],"generally":[16],"regarded":[17],"as":[18,203],"\"benign\"":[19],"of":[21,36,198,210,221,229],"brain.":[23],"Malignant":[24],"meningiomas":[25,86],"rare":[27],"typically":[30],"associated":[31],"with":[32,112,158],"a":[33,41,62,194,204],"higher":[34],"risk":[35],"local":[37],"tumor":[38],"recurrence":[39],"poorer":[42],"prognosis":[43],"(median":[44],"survival":[45],"time":[46],"<2":[47],"years).":[48],"Previous":[49],"genome-wide":[50],"association":[51],"studies":[52,56,70,233],"exome":[54,81,142],"sequencing":[55,82,143,232],"have":[57],"identified":[58,109,146,172],"genes":[59,111,150,166],"that":[60,188],"play":[61,193],"role":[63,195],"in":[64,161,167,176,190,196],"susceptibility":[65],"to":[66,104],"meningiomas,":[67,199,223],"but":[68,224],"these":[69,165],"did":[71],"not":[72],"focus":[73],"specifically":[74],"on":[75,83,87,130,235],"malignant":[76,85,138,208,222,237],"tumors.":[77,162],"METHODS:":[78],"We":[79,99,122,163,186],"performed":[80],"five":[84,131],"Illumina":[89],"HiSeq2000":[90],"platform":[91],"using":[92],"Agilent":[93],"SureSelect":[94],"Human":[95],"All":[96],"Exon":[97],"kits.":[98],"used":[100],"wANNOVAR":[101],"web":[102],"server":[103],"annotate":[105],"prioritize":[107],"variants,":[108],"candidate":[110,132,205],"recurrent":[113],"mutations,":[114],"validated":[116],"selected":[117],"mutations":[118,160,175,189],"by":[119,217],"Sanger":[120],"sequencing.":[121],"next":[123],"designed":[124],"custom":[125],"NimbleGen":[126],"targeted":[127],"region":[128],"arrays":[129],"genes,":[133],"sequenced":[135,164],"four":[136,168],"additional":[137,169],"meningiomas.":[139,211],"RESULTS:":[140],"From":[141],"data,":[144],"we":[145],"several":[147],"frequently":[148],"mutated":[149],"including":[151],"NF2,":[152],"MN1,":[153],"ARID1B,":[154],"SEMA4D,":[155],"MUC2,":[157],"private":[159],"samples":[170],"potential":[173],"driver":[174],"NF2":[177,191],"(neurofibromatosis":[178],"type":[179],"2)":[180],"MN1":[182,202],"(meningioma":[183],"1).":[184],"CONCLUSIONS:":[185],"confirmed":[187],"may":[192],"progression":[197],"nominated":[201],"gene":[206],"for":[207],"transformation":[209],"Our":[212],"sample":[213],"size":[214],"is":[215],"limited":[216],"extreme":[219],"rarity":[220],"our":[225],"study":[226],"represents":[227],"one":[228],"first":[231],"focusing":[234],"subtype.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}