{"id":"https://openalex.org/W2354411595","doi":null,"title":"Overexpression of gamma-aminobutyric acid transporter subtype I leads to cognitive deterioration in transgenic mice.","display_name":"Overexpression of gamma-aminobutyric acid transporter subtype I leads to cognitive deterioration in transgenic mice.","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W2354411595","mag":"2354411595","pmid":"https://pubmed.ncbi.nlm.nih.gov/11742587"},"language":"en","primary_location":{"id":"pmid:11742587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11742587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y H Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y H Ma","raw_affiliation_strings":["Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China","institution_ids":["https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049891500","display_name":"Xiaogang Zhou","orcid":"https://orcid.org/0000-0002-2574-3973","observed_orcids":["https://orcid.org/0000-0002-2574-3973"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X G Zhou","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S H Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S H Duan","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103223758","display_name":"Jia Hua Hu","orcid":"https://orcid.org/0000-0002-5829-2638","observed_orcids":["https://orcid.org/0000-0002-5829-2638"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054716302","display_name":"Bin L\u00fc","orcid":"https://orcid.org/0000-0001-6675-0785","observed_orcids":["https://orcid.org/0000-0001-6675-0785"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B F Lu","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402153","display_name":"Yi Yu","orcid":"https://orcid.org/0009-0007-6283-4392","observed_orcids":["https://orcid.org/0009-0007-6283-4392"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Yu","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Z T Mei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z T Mei","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Fei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J Fei","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030476917","display_name":"L H Guo","orcid":"https://orcid.org/0000-0002-6283-3548","observed_orcids":["https://orcid.org/0000-0002-6283-3548"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210121447","display_name":"Center for Excellence in Molecular Cell Science","ror":"https://ror.org/02rrdvm96","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L H Guo","raw_affiliation_strings":["CAS - Shanghai Institute of Biochemistry and Cell Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS - Shanghai Institute of Biochemistry and Cell Biology","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210121447"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6321,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.61500766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"22","issue":"4","first_page":"340","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gat1","display_name":"GABA transporter 1","score":0.7580000162124634},{"id":"https://openalex.org/keywords/gaba-uptake","display_name":"GABA uptake","score":0.6790000200271606},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.621999979019165},{"id":"https://openalex.org/keywords/memory-retention","display_name":"memory retention","score":0.6439999938011169},{"id":"https://openalex.org/keywords/associative-learning","display_name":"associative learning","score":0.9919999837875366},{"id":"https://openalex.org/keywords/avoidance-conditioning","display_name":"avoidance conditioning","score":0.7310000061988831},{"id":"https://openalex.org/keywords/asymmetric-synapses","display_name":"asymmetric synapses","score":0.7429999709129333},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.8799999952316284},{"id":"https://openalex.org/keywords/overexpression","display_name":"overexpression","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.776416540145874},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7468640804290771},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.7254598736763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5082775950431824},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.49764779210090637},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44580143690109253},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.41518551111221313},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.40628811717033386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3694561719894409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33260267972946167},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32793331146240234},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.296966552734375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23820823431015015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1301407814025879}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012153","descriptor_name":"Retention, Psychology","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11742587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11742587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:2354411595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11742587","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W993326550","https://openalex.org/W2087605748","https://openalex.org/W3151256186","https://openalex.org/W235932831","https://openalex.org/W3147265771","https://openalex.org/W1644388421","https://openalex.org/W7097613531","https://openalex.org/W2151875814","https://openalex.org/W1974178559","https://openalex.org/W4394974977"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"explore":[2],"the":[3,150,156,183,186,195],"physiological":[4],"role":[5],"of":[6,25,38,44,80,95,112,152,158,173,188],"gamma-aminobutyric":[7,189],"acid":[8,190],"transporter":[9],"subtype":[10],"I":[11],"(GAT1)":[12],"in":[13,34,41,109,140,146,155,175,178,185,194],"cognition.":[14],"METHODS:":[15],"Transgenic":[16],"mice":[17,91,123,160,176],"were":[18,97],"produced":[19],"by":[20,29,48,56,66,74,84,164],"pronuclei":[21],"microinjection":[22],"method.":[23],"Integration":[24],"transgene":[26,96],"was":[27,46,54,64,72,82,100,161],"identified":[28],"Southern-blot":[30],"and":[31,58,106,133,142],"PCR":[32],"analysis":[33],"various":[35,93],"generations.":[36],"Level":[37],"GAT1":[39,52,99,174],"mRNA":[40,105],"a":[42,110],"variety":[43,111],"tissues":[45,113],"evaluated":[47],"semi-quantitative":[49],"RT-PCR":[50],"analysis.":[51,60],"protein":[53,107],"detected":[55],"immunofluorescence":[57],"histochemistry":[59],"Associative":[61],"learning":[62,128],"capacity":[63,129],"analyzed":[65],"conditioned":[67],"avoidance":[68],"task.":[69],"Memory":[70],"retention":[71,136],"assessed":[73],"novel":[75],"object":[76],"recognition":[77],"test.":[78],"Morphology":[79],"synaptosomes":[81],"examined":[83],"electron":[85],"microscope.":[86],"RESULTS:":[87],"Four":[88],"independent":[89],"founder":[90],"bearing":[92],"copies":[94],"generated.":[98],"evidently":[101],"overexpressed":[102],"at":[103],"both":[104],"level":[108],"from":[114],"transgenic":[115,122,159],"mice.":[116,170],"In":[117,148],"comparison":[118],"with":[119],"wild-type":[120,169],"mice,":[121],"exhibited":[124],"significantly":[125],"declined":[126],"associative":[127],"(P":[130,137],"<":[131,138,144],"0.01)":[132],"decreased":[134],"memory":[135],"0.01":[139],"1-h-retention,":[141],"P":[143],"0.05":[145],"1-d-retention).":[147],"addition,":[149],"amount":[151],"asymmetric":[153],"synapses":[154],"brain":[157],"reduced":[162],"approximately":[163],"24":[165],"%,":[166],"relative":[167],"to":[168],"CONCLUSION:":[171],"Overexpression":[172],"results":[177],"cognitive":[179,200],"deterioration,":[180],"indicating":[181],"that":[182],"alteration":[184],"expression":[187],"transporters":[191],"is":[192],"involved":[193],"pathophysiological":[196],"mechanism":[197],"underlying":[198],"some":[199],"deficiencies.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
