{"id":"https://openalex.org/W2353611136","doi":null,"title":"[Quercetin permeability across blood-brain barrier and its effect on the viability of U251 cells].","display_name":"[Quercetin permeability across blood-brain barrier and its effect on the viability of U251 cells].","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2353611136","mag":"2353611136","pmid":"https://pubmed.ncbi.nlm.nih.gov/21302433"},"language":"zh","primary_location":{"id":"pmid:21302433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21302433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040972891","display_name":"Sichong Ren","orcid":"https://orcid.org/0000-0001-7311-4314","observed_orcids":["https://orcid.org/0000-0001-7311-4314"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-chong Ren","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058090999","display_name":"Qifeng Suo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi-feng Suo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Wen-ting Du","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wen-ting Du","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101534744","display_name":"Hong Pan","orcid":"https://orcid.org/0009-0009-7451-4294","observed_orcids":["https://orcid.org/0009-0009-7451-4294","https://orcid.org/0000-0002-8124-8184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Pan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006202965","display_name":"Mingming Yang","orcid":"https://orcid.org/0000-0001-8843-4935","observed_orcids":["https://orcid.org/0000-0001-8843-4935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming-ming Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051184099","display_name":"Ruo-han Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruo-han Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100396324","display_name":"Ji Liu","orcid":"https://orcid.org/0000-0002-5692-7513","observed_orcids":["https://orcid.org/0000-0002-5692-7513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ji Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3672,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.65876193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"5","first_page":"751","last_page":"4, 759"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9850000143051147},{"id":"https://openalex.org/keywords/u251-cells","display_name":"U251 cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.7269999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/brain-microvascular-endothelial-cells","display_name":"brain microvascular endothelial cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9750000238418579},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.8989999890327454},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.7716113328933716},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7501028776168823},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6224005818367004},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.5808213949203491},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.5765438079833984},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.566806435585022},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48996391892433167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48035988211631775},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.44526875019073486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42364662885665894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35765254497528076},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2172124683856964},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.16047480702400208},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.07234591245651245},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.059853702783584595}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:21302433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21302433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition","raw_type":"English Abstract"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3032379932","https://openalex.org/W3009338790","https://openalex.org/W2497667677","https://openalex.org/W2045730256","https://openalex.org/W3135719357","https://openalex.org/W2037168210","https://openalex.org/W2472051450","https://openalex.org/W2384526853","https://openalex.org/W3174422902","https://openalex.org/W2009779220"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,15,119,123,134,140,148,152],"permeability":[4,66],"of":[5,19,30,115,125,154],"quercetin":[6,65,116],"across":[7,67,118,147],"blood-brain":[8],"barrier":[9],"(BBB)":[10],"and":[11,17,37,50,89,102,127,157],"its":[12],"impact":[13],"on":[14],"proliferation":[16,124,153],"apoptosis":[18],"U251":[20,69,126,135,155],"cells.":[21],"METHODS:":[22],"The":[23,107,130],"BBB":[24,108,149],"model":[25],"was":[26,43,61,109],"established":[27],"through":[28],"culture":[29],"primary":[31,38],"brain":[32],"microvessel":[33],"endothelial":[34],"cells":[35,40,70,136,156],"(BMVEC)":[36],"astroglia":[39],"(AC),":[41],"which":[42],"confirmed":[44],"by":[45],"transmission":[46],"electron":[47],"microscopy":[48],"(TEM)":[49],"trans":[51],"epithelial":[52],"electric":[53],"resistance":[54],"(TEER).":[55],"High":[56],"pressure":[57],"liquid":[58],"chromatography":[59],"(HPLC)":[60],"performed":[62,94],"to":[63,73,95,113],"determine":[64],"BBB.":[68,120],"were":[71,93,137],"exposed":[72],"quercetin.":[74],"MTT":[75],"assay,":[76],"terminal":[77],"deoxynucleotidyl":[78],"transferase-mediated":[79],"dUTP":[80],"nick":[81],"end":[82],"labeling":[83],"(TUNEL),":[84],"single-cell":[85],"gel":[86],"electrophoresis":[87],"(SCGE)":[88],"flow":[90],"cytometry":[91],"(FCM)":[92],"analyze":[96],"cell":[97,103],"proliferation,":[98],"apoptosis,":[99],"DNA":[100],"damage":[101],"cycle":[104],"distribution.":[105],"RESULTS:":[106],"constructed":[110],"successfully.":[111],"Up":[112],"65.54%":[114],"permeated":[117],"Quercetin":[121,144],"attenuated":[122],"induced":[128],"apoptosis.":[129,159],"FCM":[131],"revealed":[132],"that":[133],"inhibited":[138],"at":[139],"G2/M":[141],"point.":[142],"CONCLUSION:":[143],"can":[145],"permeate":[146],"effectively,":[150],"restraining":[151],"inducing":[158]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}