{"id":"https://openalex.org/W2353576099","doi":null,"title":"Effects of NO donor on the proliferation differentiation and expression of bone morphogenetic protein-2 in rat osteoblasts","display_name":"Effects of NO donor on the proliferation differentiation and expression of bone morphogenetic protein-2 in rat osteoblasts","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2353576099","mag":"2353576099"},"language":"en","primary_location":{"id":"mag:2353576099","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XBGY201206028.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764563677","display_name":"Medical Journal of National Defending Forces in Northwest China","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4364148198","host_organization_name":"Peking University Library","host_organization_lineage":["https://openalex.org/P4364148198"],"host_organization_lineage_names":["Peking University Library"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medical Journal of National Defending Forces in Northwest China","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049091907","display_name":"Le Kang","orcid":"https://orcid.org/0000-0003-4262-2329","observed_orcids":["https://orcid.org/0000-0003-4262-2329","https://orcid.org/0000-0003-3930-1217"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Le Kang","raw_affiliation_strings":["E,et al"],"raw_orcid":"https://orcid.org/0000-0003-4262-2329","affiliations":[{"raw_affiliation_string":"E,et al","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5049091907"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19562409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/noc-18","display_name":"NOC-18","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8899999856948853},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9739999771118164},{"id":"https://openalex.org/keywords/osteoblast-proliferation","display_name":"osteoblast proliferation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/calvarial-bone","display_name":"calvarial bone","score":0.7689999938011169},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.8939746618270874},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.7436130046844482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.662956953048706},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5421867966651917},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5022273063659668},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4922098219394684},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.48610949516296387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4810183644294739},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4282114505767822},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4136420786380768},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19655045866966248},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18761810660362244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1732771098613739},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17033812403678894},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1350926160812378},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.039710283279418945}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2353576099","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-XBGY201206028.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764563677","display_name":"Medical Journal of National Defending Forces in Northwest China","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4364148198","host_organization_name":"Peking University Library","host_organization_lineage":["https://openalex.org/P4364148198"],"host_organization_lineage_names":["Peking University Library"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medical Journal of National Defending Forces in Northwest China","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4283825397","https://openalex.org/W2364407322","https://openalex.org/W2046308113","https://openalex.org/W2391769370","https://openalex.org/W3174135553","https://openalex.org/W2029610877","https://openalex.org/W7097350638","https://openalex.org/W2051213196","https://openalex.org/W1997931173","https://openalex.org/W2077336138"],"abstract_inverted_index":{"Objective:To":[0],"study":[1],"the":[2,8,37,49,75,82,91,140,149],"effects":[3,98,126,141],"of":[4,13,26,32,44,60,77,108,115,122,132,142,151],"nitric":[5],"oxide(NO)":[6],"on":[7,71,99,127],"proliferation":[9,51,69,112,129],"differentiation":[10,102,114,131],"and":[11,35,73,101,113,117,130],"expression":[12,59,76,150],"bone":[14,25,119],"morphogenetic":[15],"protein-2(BMP-2)":[16],"in":[17,42,46,103,144],"rat":[18,104],"osteoblasts.Methods:":[19],"Osteoblasts":[20],"were":[21,40,80],"isolated":[22],"from":[23],"calvarial":[24],"SD":[27],"rats":[28],"by":[29,54,64],"combined":[30],"means":[31],"enzymatic":[33],"digestion":[34],"fragments.Then":[36],"cultured":[38],"cells":[39],"added":[41],"NOC-18":[43,66,87],"concentration":[45,107,121],"0,1,10,100":[47],"umol,and":[48],"cell":[50],"was":[52,62,146],"measured":[53],"thiazoly":[55],"blue(MTT)":[56],"assay.The":[57],"protein":[58],"BMP-2":[61,79],"determined":[63],"immunocytochemisty.Results:":[65],"had":[67,90,96,124],"significant":[68],"effect":[70],"osteoblasts":[72,78,135],"all":[74],"increased.Among":[81],"3":[83],"groups,the":[84],"group":[85],"with":[86,148],"10":[88],"umol":[89],"strongest":[92],"osteoblast":[93,116,145],"proliferation.Conclusion:":[94],"NO":[95,109,123,143],"dual":[97],"proliferaton":[100],"osteoblasts.Moderate":[105],"low":[106],"could":[110],"stimulate":[111],"increase":[118],"formation;high":[120],"weak":[125],"stimulating":[128],"osteoblast,even":[133],"inhibiting":[134],"differentiation.The":[136],"results":[137],"showed":[138],"that":[139],"correlated":[147],"BMP-2.":[152]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}