{"id":"https://openalex.org/W2353224147","doi":"https://doi.org/10.1016/j.eurpsy.2016.01.1701","title":"Serine Racemase in Inhibitory Neurons at Striatum and it Might be Involved in Schizophrenia's Pathophysiology with d1 and d2 Receptors","display_name":"Serine Racemase in Inhibitory Neurons at Striatum and it Might be Involved in Schizophrenia's Pathophysiology with d1 and d2 Receptors","publication_year":2016,"publication_date":"2016-03-01","ids":{"openalex":"https://openalex.org/W2353224147","doi":"https://doi.org/10.1016/j.eurpsy.2016.01.1701","mag":"2353224147"},"language":"en","primary_location":{"id":"doi:10.1016/j.eurpsy.2016.01.1701","doi":"https://doi.org/10.1016/j.eurpsy.2016.01.1701","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eurpsy.2016.01.1701","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038445482","display_name":"Shunsuke Takagi","orcid":"https://orcid.org/0000-0001-7289-6553","observed_orcids":["https://orcid.org/0000-0001-7289-6553"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"S. Takagi","raw_affiliation_strings":["Tokyo Medical and Dental University, Psychiatry, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tokyo Medical and Dental University, Psychiatry, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051690277","display_name":"Darrick T. Balu","orcid":"https://orcid.org/0000-0003-3505-6832","observed_orcids":["https://orcid.org/0000-0003-3505-6832"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Balu","raw_affiliation_strings":["Harvard Medical School, Department of Psychiatry, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Psychiatry, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056026158","display_name":"Joseph T. Coyle","orcid":"https://orcid.org/0000-0002-0702-1395","observed_orcids":["https://orcid.org/0000-0002-0702-1395"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Coyle","raw_affiliation_strings":["Harvard Medical School, Department of Psychiatry, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Department of Psychiatry, Boston, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038445482"],"corresponding_institution_ids":["https://openalex.org/I125602781"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"S1","first_page":"S467","last_page":"S467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.8809000253677368,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.08579999953508377,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.013500000350177288,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-racemase","display_name":"serine racemase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/d-serine","display_name":"D-serine","score":0.878000020980835},{"id":"https://openalex.org/keywords/inhibitory-neurons","display_name":"inhibitory neurons","score":0.9160000085830688},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9520000219345093},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nmda-receptor-hypofunction","display_name":"NMDA receptor hypofunction","score":0.8600000143051147},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.8870000243186951},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":1.0},{"id":"https://openalex.org/keywords/medium-spiny-neurons","display_name":"medium spiny neurons","score":0.8460000157356262},{"id":"https://openalex.org/keywords/schizophrenia-pathophysiology","display_name":"schizophrenia pathophysiology","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.7372178435325623},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.660788893699646},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6568210124969482},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.641728937625885},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5605857968330383},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5553097128868103},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.5326093435287476},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.46260082721710205},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.44309040904045105},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4194400906562805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.402663916349411},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38538846373558044},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36897730827331543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3458084762096405},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.32461291551589966},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25301724672317505},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.1783725917339325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15835589170455933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1136445701122284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.eurpsy.2016.01.1701","doi":"https://doi.org/10.1016/j.eurpsy.2016.01.1701","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eurpsy.2016.01.1701","pdf_url":null,"source":{"id":"https://openalex.org/S87202501","display_name":"European Psychiatry","issn_l":"0924-9338","issn":["0924-9338","1778-3585"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Psychiatry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2513410811","https://openalex.org/W2517243612","https://openalex.org/W3026035490","https://openalex.org/W2768766048","https://openalex.org/W2898784992","https://openalex.org/W2327241846","https://openalex.org/W3165692674","https://openalex.org/W2511496678","https://openalex.org/W2145566795","https://openalex.org/W2051513718"],"abstract_inverted_index":{"Introduction":[0],"There":[1],"is":[2,12,195,214],"substantial":[3],"evidence":[4],"that":[5,44],"hypofunction":[6],"of":[7,58,91,102,111,168,181,200,239,248],"the":[8,89,107],"N-methyl-d-aspartate":[9],"receptor":[10],"(NMDAR)":[11],"a":[13],"core":[14],"pathophysiological":[15],"mechanism":[16],"underlying":[17],"schizophrenia.":[18],"d-serine":[19,68,92,112,144,180],"and":[20,26,69,93,98,109,113,158,177,202,209,235],"serine":[21],"racemase":[22],"(SR)":[23],"(NMDAR":[24],"co-agonist":[25],"it's":[27],"producer)":[28],"are":[29,71,101],"thought":[30],"to":[31],"be":[32,225],"involved":[33,226],"in":[34,73,78,95,115,170,175,196,216,221,227],"schizophrenia's":[35,228],"pathophysiology":[36,229],"as":[37],"NMDAR":[38,85],"function":[39],"moderators.":[40],"Our":[41],"laboratory":[42],"showed":[43],"excitatory":[45,79,87],"neuron":[46,120,199],"specific":[47,123],"SR":[48,59,70,94,114,149,153,169,194,213],"knock":[49],"out":[50],"(SRKO)":[51],"mice":[52,63,128,138,184],"still":[53],"have":[54,243],"just":[55],"50%":[56,166],"reduction":[57,167,174],"whereas":[60],"full":[61],"SRKO":[62,125,137,163,183],"had":[64,164],"no":[65,173],"SR.":[66],"Furthermore":[67],"found":[72],"inhibitory":[74,96,116,217],"neurons":[75,80,97,218],"not":[76,186,244],"only":[77],"with":[81,205,233],"immunohistochemistry":[82,151],"methods.":[83],"Because":[84],"has":[86,203],"functions,":[88],"existence":[90,108],"their":[99,246],"functions":[100],"interest.":[103,250],"Aims":[104],"To":[105],"elucidate":[106],"roles":[110],"neurons.":[117],"Methods":[118],"Inhibitory":[119],"marker,":[121],"GAD65,":[122],"conditional":[124],"(GAD65":[126],"SRKO)":[127],"were":[129,139],"made":[130],"by":[131,141],"Cre-lox":[132],"recombination":[133],"method.":[134],"The":[135,241],"GAD65":[136,162,182],"analyzed":[140],"HPLC":[142],"for":[143,148,152],"concentration,":[145],"western":[146],"blotting":[147],"expression,":[150],"positive":[154],"cell's":[155],"character":[156],"identification":[157],"behavioral":[159],"testing.":[160],"Results":[161],"about":[165],"striatum":[171,201],"but":[172],"hippocampus":[176],"frontal":[178],"cortex.":[179],"was":[185],"different":[187],"from":[188],"WT":[189],"mice.":[190],"Immunohistochemistry":[191],"works":[192],"revealed":[193],"medium":[197],"spiny":[198],"colocalization":[204],"DARRP-32,":[206],"D1":[207,234],"receptor,":[208],"D2":[210,236],"receptor.":[211],"Conclusions":[212],"expressed":[215],"at":[219],"least":[220],"striatum.":[222],"It":[223],"might":[224],"because":[230],"it":[231],"colocalizes":[232],"receptors.":[237],"Disclosure":[238],"interest":[240],"authors":[242],"supplied":[245],"declaration":[247],"competing":[249]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2016-06-24T00:00:00"}