{"id":"https://openalex.org/W2352889720","doi":null,"title":"[Effect of triclabendazole on the ultrastructure of body wall and vitelline cells of Paragonimus westermani].","display_name":"[Effect of triclabendazole on the ultrastructure of body wall and vitelline cells of Paragonimus westermani].","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2352889720","mag":"2352889720","pmid":"https://pubmed.ncbi.nlm.nih.gov/12563729"},"language":"zh","primary_location":{"id":"pmid:12563729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12563729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101775437","display_name":"Xu Shi","orcid":"https://orcid.org/0000-0002-6549-3331","observed_orcids":["https://orcid.org/0000-0002-6549-3331"]},"institutions":[{"id":"https://openalex.org/I4210120522","display_name":"Shantou University Medical College","ror":"https://ror.org/02gxych78","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210120522"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"S Xu","raw_affiliation_strings":["Department of Parasitology, Shantou University Medical College, Shantou 515031"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology, Shantou University Medical College, Shantou 515031","institution_ids":["https://openalex.org/I4210120522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067596610","display_name":"Chia\u2010Yu Chen","orcid":"https://orcid.org/0000-0002-8989-691X","observed_orcids":["https://orcid.org/0000-0002-8989-691X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043526045","display_name":"Lihua Jin","orcid":"https://orcid.org/0000-0002-2685-6048","observed_orcids":["https://orcid.org/0000-0002-2685-6048"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106524710","display_name":"Lu X","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5015584071","display_name":"J Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"6","first_page":"342","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals","score":0.1282999962568283,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triclabendazole","display_name":"triclabendazole","score":0.9829999804496765},{"id":"https://openalex.org/keywords/paragonimus-westermani","display_name":"Paragonimus westermani","score":1.0},{"id":"https://openalex.org/keywords/lung-fluke","display_name":"lung fluke","score":0.8610000014305115},{"id":"https://openalex.org/keywords/antiparasitic-efficacy","display_name":"antiparasitic drug efficacy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ultrastructural-damage","display_name":"ultrastructural damage","score":0.6729999780654907},{"id":"https://openalex.org/keywords/body-wall","display_name":"body wall","score":0.8730000257492065},{"id":"https://openalex.org/keywords/vitelline-cells","display_name":"vitelline cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nuclear-membrane-damage","display_name":"nuclear membrane damage","score":0.7369999885559082},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.6959999799728394},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mitochondria","display_name":"mitochondria","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.7704732418060303},{"id":"https://openalex.org/C2777861111","wikidata":"https://www.wikidata.org/wiki/Q419739","display_name":"Triclabendazole","level":4,"score":0.7191798686981201},{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.6792083978652954},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.57857745885849},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4885293245315552},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4719133675098419},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.41668885946273804},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40278685092926025},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39536967873573303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32623326778411865},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.0811711847782135},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.058811038732528687},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2777856171","wikidata":"https://www.wikidata.org/wiki/Q334149","display_name":"Fasciola hepatica","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077682","descriptor_name":"Triclabendazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000871","descriptor_name":"Anthelmintics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010238","descriptor_name":"Paragonimus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010238","descriptor_name":"Paragonimus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D014817","descriptor_name":"Vitelline Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014817","descriptor_name":"Vitelline Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12563729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12563729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases","raw_type":"Journal Article"},{"id":"mag:2352889720","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12563729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W640203145","https://openalex.org/W2300896658","https://openalex.org/W2350768123","https://openalex.org/W801759594","https://openalex.org/W2299947828","https://openalex.org/W2413745866","https://openalex.org/W1813951284","https://openalex.org/W2348800094","https://openalex.org/W2412143483","https://openalex.org/W2370702435"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"observe":[2],"the":[3,7,11,41,72,77,135,143],"ultrastructural":[4],"changes":[5],"in":[6,17,20,33,36,120,123],"body":[8,136],"wall":[9,137],"and":[10,19,23,35,48,55,65,86,98,102,113,138,147],"vitelline":[12,87,139],"cells":[13,88],"of":[14,40,76,84],"Paragonimus":[15,131],"westermani":[16,132],"vitro":[18,34],"vivo":[21,37,121],"before":[22],"after":[24,71],"triclabendazole":[25],"treatment.":[26,73],"METHODS:":[27],"The":[28,61,74,81,104,115],"worms":[29],"were":[30,43,67,89],"obtained":[31],"from":[32],"tests.":[38],"All":[39],"samples":[42],"processed":[44],"by":[45,50,133],"conventional":[46],"techniques,":[47],"observed":[49],"scanning":[51],"electron":[52,57],"microscopy":[53,58],"(SEM)":[54],"transmission":[56],"(TEM).":[59],"RESULTS:":[60],"external":[62],"plasma":[63],"membrane":[64,92,145],"matrix":[66],"cracked":[68],"or":[69],"disappeared":[70],"necrosis":[75],"muscular":[78],"layer":[79],"differed.":[80],"cell":[82],"membranes":[83],"cortex":[85],"damaged.":[90],"Nuclear":[91],"was":[93,117],"damaged":[94],"partially,":[95],"heterochromatin":[96],"solidified":[97],"condensed":[99],"to":[100],"brim":[101],"dissolved.":[103,114],"Golgi":[105],"complex":[106],"disappeared,":[107],"endoplasmic":[108],"reticulum":[109],"expanded,":[110],"mitochodria":[111],"denatured":[112],"damage":[116],"more":[118],"serious":[119],"than":[122],"vitro.":[124],"CONCLUSION:":[125],"Triclabendazole":[126],"is":[127],"remarkablely":[128],"effective":[129],"against":[130],"damaging":[134],"cells,":[140],"mainly":[141],"affecting":[142],"nuclei,":[144],"structures":[146],"microtubular":[148],"system.":[149]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}