{"id":"https://openalex.org/W2351820163","doi":null,"title":"The expression of recombinant thymosin alpha 1 in E.coli and its biological function","display_name":"The expression of recombinant thymosin alpha 1 in E.coli and its biological function","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2351820163","mag":"2351820163"},"language":"en","primary_location":{"id":"mag:2351820163","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZSYX201210007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764620810","display_name":"Zhongguo shouyi xuebao","issn_l":"1005-4545","issn":["1005-4545"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322696411","host_organization_name":"Jilin University","host_organization_lineage":["https://openalex.org/P4322696411"],"host_organization_lineage_names":["Jilin University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shouyi xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030417274","display_name":"MA Feng-long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392021163","display_name":"Shandong Sinder Technology Co., Ltd.","ror":"https://ror.org/02nak7d72","country_code":"CN","type":"company","lineage":["https://openalex.org/I4392021163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MA Feng-long","raw_affiliation_strings":["Shandong Sinder Technology Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Sinder Technology Co","institution_ids":["https://openalex.org/I4392021163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047318997","display_name":"Xuezhi Cui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xuezhi Cui","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048714815","display_name":"Huanzhen Liu","orcid":"https://orcid.org/0009-0006-9499-3171","observed_orcids":["https://orcid.org/0009-0006-9499-3171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huanzhen Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033987444","display_name":"Huanqi Liu","orcid":"https://orcid.org/0000-0002-1685-2609","observed_orcids":["https://orcid.org/0000-0002-1685-2609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huanqi Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110370251","display_name":"Lili Jiang","orcid":"https://orcid.org/0000-0002-8466-591X","observed_orcids":["https://orcid.org/0000-0002-8466-591X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023647778","display_name":"Ren Qingna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4392021163","display_name":"Shandong Sinder Technology Co., Ltd.","ror":"https://ror.org/02nak7d72","country_code":"CN","type":"company","lineage":["https://openalex.org/I4392021163"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ren Qingna","raw_affiliation_strings":["Shandong Sinder Technology Co"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Sinder Technology Co","institution_ids":["https://openalex.org/I4392021163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19366624,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"10","first_page":"1448","last_page":"1451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.24449999630451202,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.13210000097751617,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymosin-alpha-1","display_name":"thymosin alpha 1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.9929999709129333},{"id":"https://openalex.org/keywords/escherichia-coli-bl21-de3","display_name":"Escherichia coli BL21(DE3)","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ni2-affinity-chromatography","display_name":"Ni2+ affinity chromatography","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lymphocyte-transformation","display_name":"lymphocyte transformation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/e-rosette-formation","display_name":"E-rosette formation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5920000076293945},{"id":"https://openalex.org/keywords/codon-optimization","display_name":"codon optimization","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.9131859540939331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7178685069084167},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7095487117767334},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6462596654891968},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5996898412704468},{"id":"https://openalex.org/C179247698","wikidata":"https://www.wikidata.org/wiki/Q382799","display_name":"Affinity chromatography","level":3,"score":0.4904501140117645},{"id":"https://openalex.org/C2776451592","wikidata":"https://www.wikidata.org/wiki/Q424656","display_name":"Thymosin","level":2,"score":0.46455615758895874},{"id":"https://openalex.org/C33161422","wikidata":"https://www.wikidata.org/wiki/Q5421712","display_name":"Expression vector","level":4,"score":0.43618881702423096},{"id":"https://openalex.org/C170344550","wikidata":"https://www.wikidata.org/wiki/Q311359","display_name":"lac operon","level":4,"score":0.42159438133239746},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30943095684051514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2187177836894989},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12039637565612793}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2351820163","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZSYX201210007.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764620810","display_name":"Zhongguo shouyi xuebao","issn_l":"1005-4545","issn":["1005-4545"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4322696411","host_organization_name":"Jilin University","host_organization_lineage":["https://openalex.org/P4322696411"],"host_organization_lineage_names":["Jilin University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shouyi xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2363114149","https://openalex.org/W2389431551","https://openalex.org/W2392027514","https://openalex.org/W7100592688","https://openalex.org/W2359165711","https://openalex.org/W2424892411","https://openalex.org/W2367343695","https://openalex.org/W2392234961","https://openalex.org/W1995678243","https://openalex.org/W2367660226"],"abstract_inverted_index":{"According":[0],"to":[1,12],"Escherichia":[2,15],"coli":[3,16],"codon":[4],"preference,synthesize":[5],"thymosin":[6,115],"alpha":[7],"1(T\u03b11)":[8],"gene":[9],"and":[10,77],"attach":[11],"vector":[13],"pET32\u03b1(+),convert":[14],"BL21(DE3).After":[17],"IPTG":[18],"induction,by":[19],"15%":[20],"SDS-PAGE":[21],"detected,T\u03b11":[22],"obtain":[23],"soluble":[24],"expression.A":[25],"positive":[26],"fusion":[27,85],"protein":[28,31,61],"band,which":[29],"matches":[30],"molecular":[32],"weight":[33],"about":[34],"21":[35],"800,was":[36],"detected":[37,72],"in":[38,144],"the":[39,42,57,106,111,121,129,147],"expression":[40],"product.Then":[41],"expressed":[43],"recombinant":[44,69,84,100,137],"T\u03b11":[45,70,86,101,138],"was":[46,54,63,71,102],"purified":[47,68,99],"by":[48,56,73],"Ni2+":[49],"affinity":[50],"chromatography,and":[51],"test":[52,76],"samples":[53],"prepared":[55],"desalination":[58],"after":[59],"eluting":[60],"peaks":[62],"collected.The":[64],"immune":[65],"activity":[66,130,143],"of":[67,98,114,120,123,131],"lymphocyte":[74,93],"transformation":[75],"E":[78,95,124],"rosette":[79,96],"test.The":[80],"results":[81,134],"showed":[82],"that":[83,136],"could":[87,126],"obviously":[88],"promote":[89],"BALB/c":[90],"mice":[91],"spleen":[92],"proliferation.The":[94],"percentage":[97,122],"higher":[103,109],"14.3%":[104],"than":[105,110,118],"control":[107],"group,being":[108],"quality":[112],"standards":[113],"solution(not":[116],"less":[117],"10%":[119],"rosette),indicating":[125],"significantly":[127],"enhance":[128],"T":[132],"cells.These":[133],"suggest":[135],"have":[139],"a":[140],"similar":[141],"immunological":[142],"vitro,compared":[145],"with":[146],"synthetic":[148],"or":[149],"natural":[150],"T\u03b11.":[151]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
