{"id":"https://openalex.org/W2351469732","doi":null,"title":"Role of angiotensin II in the regulation of platelet-derived growth factor receptor \u03b2 subunit of vascular smooth muscle","display_name":"Role of angiotensin II in the regulation of platelet-derived growth factor receptor \u03b2 subunit of vascular smooth muscle","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2351469732","mag":"2351469732"},"language":"en","primary_location":{"id":"mag:2351469732","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200106001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo bingli shengli zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101669910","display_name":"Dongqi Xing","orcid":"https://orcid.org/0000-0003-2227-3571","observed_orcids":["https://orcid.org/0000-0003-2227-3571"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dongqi Xing","raw_affiliation_strings":["1,BAI Hua  2,SUN Yin-ping  3,LIU Jie  1, WU Li-ling  1"],"raw_orcid":"https://orcid.org/0000-0003-2227-3571","affiliations":[{"raw_affiliation_string":"1,BAI Hua  2,SUN Yin-ping  3,LIU Jie  1, WU Li-ling  1","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101669910"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.24847236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":1.0},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.9390000104904175},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7070000171661377},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.722000002861023},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9850000143051147},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.7279999852180481},{"id":"https://openalex.org/keywords/mek","display_name":"MEK","score":0.6549999713897705},{"id":"https://openalex.org/keywords/renal-hypertension","display_name":"renal hypertension","score":0.625},{"id":"https://openalex.org/keywords/2-kidney-1-clip-model","display_name":"two-kidney one-clip model","score":0.8970000147819519},{"id":"https://openalex.org/keywords/losartan","display_name":"losartan","score":0.8550000190734863},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.6793214082717896},{"id":"https://openalex.org/C2780288358","wikidata":"https://www.wikidata.org/wiki/Q410074","display_name":"Losartan","level":4,"score":0.651614248752594},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.632308304309845},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6098380088806152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6096644401550293},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5639127492904663},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5484696626663208},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4984297752380371},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49217286705970764},{"id":"https://openalex.org/C2781294074","wikidata":"https://www.wikidata.org/wiki/Q22327352","display_name":"Platelet-derived growth factor","level":5,"score":0.47118356823921204},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42864349484443665},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.42818203568458557},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.4235001802444458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.390296995639801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35651010274887085},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22222274541854858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11177718639373779},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.05522468686103821},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2351469732","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-ZBLS200106001.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2765062696","display_name":"Zhongguo bingli shengli zazhi","issn_l":"1000-4718","issn":["1000-4718"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo bingli shengli zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1971702901","https://openalex.org/W2885587112","https://openalex.org/W4232214661","https://openalex.org/W2059215487","https://openalex.org/W2069320755","https://openalex.org/W2103736967","https://openalex.org/W2116753515","https://openalex.org/W2135659250","https://openalex.org/W2154315680","https://openalex.org/W1990132316"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,79,164,180,193],"crosstalk":[4],"between":[5],"angiotensin":[6],"\u2161":[7,50],"(Ang\u2161)-mediated":[8],"and":[9,147,183,188],"platelet-derived":[10],"growth":[11],"factor":[12],"(PDGF)-mediated":[13],"signal":[14,186,195],"transduction":[15,196],"in":[16,59,95,109,192],"vascular":[17,63],"smooth":[18,64],"muscle":[19,65],"proliferation.METHODS:":[20],"A":[21],"model":[22],"of":[23,33,38,48,81,86,104,119,127,138,151,166],"renal":[24],"hypertension":[25],"was":[26,40,57,115,129,157],"made":[27],"by":[28,42,90,113,121,132,160,179],"two":[29],"kidney/one-clip":[30],"operation.":[31],"Level":[32],"PDGF":[34,52,82,105,172],"receptor":[35,53,83,106,141,173],"\u03b2":[36,54,84,107,174],"subunit":[37,55,85,108,175],"aorta":[39,87],"measured":[41],"Western":[43],"Blot":[44],"analysis.":[45],"The":[46,102,125,155],"effect":[47,126,156],"Ang":[49],"on":[51],"expression":[56,103,176],"investigated":[58],"culture":[60],"rat":[61],"aortic":[62],"cells":[66],"(VSMC).RESULTS:":[67],"Systolic":[68],"blood":[69],"pressure":[70],"obviously":[71],"increased":[72,89],"at":[73],"8th":[74],"week":[75],"after":[76],"operation,":[77],"whereas":[78],"level":[80],"significantly":[88],"126.6%":[91],"(":[92],"P0.05":[93],")":[94],"2K1C":[96],"rats":[97],"compared":[98],"with":[99,134],"control":[100,120],"group.":[101],"cultured":[110],"VSMC":[111],"stimulated":[112],"Ang\u2161":[114,128,140],"higher":[116],"than":[117],"that":[118],"192.74%(":[122],"P0.01":[123],").":[124],"inhibited":[130],"remarkably":[131],"pretreated":[133],"losartan,":[135],"a":[136,149],"kind":[137,150],"specific":[139],"1":[142,182],"(AT":[143],"1)":[144],"subtype":[145],"antagonist":[146],"U73122,":[148],"phospholipase":[152],"C":[153],"inhibitor.":[154],"partly":[158],"blocked":[159],"PD98059,":[161],"which":[162],"inhibit":[163],"activity":[165],"mitogen-activated,":[167],"ERK-activating":[168],"kinase":[169],"(MEK).CONCLUSION:":[170],"Ang\u2161-induced":[171],"is":[177],"regulated":[178],"AT":[181],"its":[184],"downstream":[185],"molecule-PLC":[187],"ERK,":[189],"might":[190],"participate":[191],"intracellular":[194],"pathway.":[197],"[":[198]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}