{"id":"https://openalex.org/W2351183751","doi":null,"title":"Preparation and Optimization of ATRA Loaded mPEG-DSPE Polymer Micelles","display_name":"Preparation and Optimization of ATRA Loaded mPEG-DSPE Polymer Micelles","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2351183751","mag":"2351183751"},"language":"en","primary_location":{"id":"mag:2351183751","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYX201019014.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764966987","display_name":"Zh\u014dnghu\u00e1 y\u00e0oxu\u00e9 z\u00e1zh\u00ec","issn_l":"1016-1015","issn":["1016-1015"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323237738","host_organization_name":"Pharmaceutical Society of the Republic of China","host_organization_lineage":["https://openalex.org/P4323237738"],"host_organization_lineage_names":["Pharmaceutical Society of the Republic of China"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zh\u014dnghu\u00e1 y\u00e0oxu\u00e9 z\u00e1zh\u00ec","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044867102","display_name":"Jinning Lou","orcid":"https://orcid.org/0000-0002-7793-5029","observed_orcids":["https://orcid.org/0000-0002-7793-5029"]},"institutions":[{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinning Lou","raw_affiliation_strings":["Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China"],"raw_orcid":"https://orcid.org/0000-0002-7793-5029","affiliations":[{"raw_affiliation_string":"Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, 100029, China","institution_ids":["https://openalex.org/I2801051648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044867102"],"corresponding_institution_ids":["https://openalex.org/I2801051648"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20449898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":0.9670000076293945},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.6790000200271606},{"id":"https://openalex.org/keywords/drug-loading-efficiency","display_name":"drug loading efficiency","score":0.8849999904632568},{"id":"https://openalex.org/keywords/drug-polymer-ratio","display_name":"drug-polymer ratio","score":0.8330000042915344},{"id":"https://openalex.org/keywords/critical-micelle-concentration","display_name":"critical micelle concentration","score":0.9179999828338623},{"id":"https://openalex.org/keywords/micelle-size","display_name":"micelle size","score":0.8790000081062317},{"id":"https://openalex.org/keywords/zeta-potential","display_name":"zeta potential","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cytotoxicity-enhancement","display_name":"cytotoxicity enhancement","score":0.6850000023841858},{"id":"https://openalex.org/keywords/hydrophobic-drug-solubilization","display_name":"hydrophobic drug solubilization","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.9100965857505798},{"id":"https://openalex.org/C2776074239","wikidata":"https://www.wikidata.org/wiki/Q2452042","display_name":"Sulforhodamine B","level":4,"score":0.7281521558761597},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.6171104907989502},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.5762830376625061},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5298259854316711},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.5094330906867981},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.4594079256057739},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.43517541885375977},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4242202639579773},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.42141860723495483},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3922145366668701},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.2912471890449524},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.2757730484008789},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.261051207780838},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.19148194789886475},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.18157890439033508},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.1485423743724823},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1311139166355133},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08617570996284485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07341498136520386},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2351183751","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZGYX201019014.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764966987","display_name":"Zh\u014dnghu\u00e1 y\u00e0oxu\u00e9 z\u00e1zh\u00ec","issn_l":"1016-1015","issn":["1016-1015"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323237738","host_organization_name":"Pharmaceutical Society of the Republic of China","host_organization_lineage":["https://openalex.org/P4323237738"],"host_organization_lineage_names":["Pharmaceutical Society of the Republic of China"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zh\u014dnghu\u00e1 y\u00e0oxu\u00e9 z\u00e1zh\u00ec","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2366531636","https://openalex.org/W2115237599","https://openalex.org/W2766348309","https://openalex.org/W3134679214","https://openalex.org/W3133868077","https://openalex.org/W2024179710","https://openalex.org/W2512496386","https://openalex.org/W2800017169","https://openalex.org/W2057598001","https://openalex.org/W2099149652"],"abstract_inverted_index":{"OBJECTIVE":[0],"To":[1],"prepare":[2],"all-trans-retinoic":[3],"acid":[4],"(ATRA)":[5],"loaded":[6,29,179],"methoxyl":[7],"poly(ethylene":[8],"glycol)-phosphatidylethanolamine":[9],"(mPEG-DSPE)":[10],"amphiphilic":[11,166],"linear":[12,167],"polymer":[13,48,142,168],"micelles":[14,30,71,97,108,119,154,181],"and":[15,20,73,98,103,114,125],"characterize":[16],"their":[17],"\u03b6":[18,74],"potential,size":[19],"loading":[21,78,105,129],"efficiency":[22,106,130],"for":[23],"optimizing":[24],"preparation":[25,112,134],"process.":[26],"METHODS":[27],"ATRA":[28,178],"with":[31,82,136],"different":[32],"drug/polymer":[33,115],"ratio":[34,116,138],"were":[35,80,109],"prepared":[36],"by":[37,111],"series":[38],"methods.":[39],"The":[40,76,118,145,165,177],"critical":[41],"micelle":[42],"concentration":[43],"(CMC)":[44],"of":[45,55,94,107,139,143,151,161,169,175],"the":[46,53,70,132,137],"mPEG-DSPE":[47,170,180],"was":[49,66,88,155],"estimated":[50],"to":[51,68,90,141,147],"prove":[52],"potential":[54],"micellar":[56],"structure":[57],"formation":[58],"using":[59],"fluorescence":[60],"spectroscopy.":[61],"Dynamic":[62],"light":[63],"scattering":[64],"(DLS)":[65],"performed":[67],"measure":[69],"size":[72,124],"potential.":[75],"drug":[77,104,128,140],"efficiencies":[79],"investigated":[81],"UV":[83],"spectrophotometry.":[84],"Sulforhodamine":[85],"B":[86],"(SRB)":[87],"used":[89],"investigate":[91],"cell":[92,149],"inhibition":[93],"drug-loaded":[95,152],"polymeric":[96,153],"free":[99,162],"drugs.":[100],"RESULTS":[101],"Size":[102],"affected":[110],"method":[113],"remarkably.":[117],"had":[120],"100":[121],"nm":[122],"in":[123,127,131,187],"17.47%":[126],"appropriate":[133],"condition":[135],"1:20.":[144],"ability":[146],"inhibit":[148],"growth":[150],"about":[156],"30":[157],"times":[158],"as":[159],"that":[160],"ATRA.":[163,176],"CONCLUSION":[164],"could":[171],"effective":[172],"load":[173],"hydrophobe":[174],"showed":[182],"obviously":[183],"solubility":[184],"cytotoxicity":[185],"enhancement":[186],"vitro.":[188]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}