{"id":"https://openalex.org/W2350468705","doi":null,"title":"Protective effects of carvedilol on myocardium cells apoptosis induced by TNF-\u03b1","display_name":"Protective effects of carvedilol on myocardium cells apoptosis induced by TNF-\u03b1","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2350468705","mag":"2350468705"},"language":"en","primary_location":{"id":"mag:2350468705","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YLZL200511019.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764721185","display_name":"Zhongguo linchuang yaolixue yu zhiliaoxue","issn_l":"1009-2501","issn":["1009-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361727491","host_organization_name":"Chinese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4361727491"],"host_organization_lineage_names":["Chinese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo linchuang yaolixue yu zhiliaoxue","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100358041","display_name":"Zhaohui Wang","orcid":"https://orcid.org/0000-0002-3253-7078","observed_orcids":["https://orcid.org/0000-0002-3253-7078"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhaohui Wang","raw_affiliation_strings":["1 Cardiovascular Department, Tongji Medical College Affiliated Union Hospital, Wuhan 430022,Hubei,China"],"raw_orcid":"https://orcid.org/0000-0002-3253-7078","affiliations":[{"raw_affiliation_string":"1 Cardiovascular Department, Tongji Medical College Affiliated Union Hospital, Wuhan 430022,Hubei,China","institution_ids":["https://openalex.org/I4210129222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100358041"],"corresponding_institution_ids":["https://openalex.org/I4210129222"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3921000063419342,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.3921000063419342,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.30709999799728394,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.27079999446868896,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":1.0},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.9817489385604858},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8831255435943604},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.8331831693649292},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.7113067507743835},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.5348381400108337},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.47370120882987976},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4213404655456543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41769081354141235},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4077299237251282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37415963411331177},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3511613607406616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34154409170150757},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3224649429321289},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1142248809337616},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.060220152139663696}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2350468705","doi":null,"is_oa":false,"landing_page_url":"https://en.cnki.com.cn/Article_en/CJFDTOTAL-YLZL200511019.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764721185","display_name":"Zhongguo linchuang yaolixue yu zhiliaoxue","issn_l":"1009-2501","issn":["1009-2501"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4361727491","host_organization_name":"Chinese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4361727491"],"host_organization_lineage_names":["Chinese Pharmacological Society"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo linchuang yaolixue yu zhiliaoxue","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063921817","https://openalex.org/W2352331490","https://openalex.org/W2076820567","https://openalex.org/W2381637318","https://openalex.org/W2399381316","https://openalex.org/W2367514103","https://openalex.org/W2364318887","https://openalex.org/W2463861286","https://openalex.org/W2315346884","https://openalex.org/W2352987715"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"explore":[2],"normal":[3,35,39,43],"myocardium":[4,26,93],"cells":[5,27,94],"apoptosis":[6,50,95],"induced":[7,96],"by":[8,51,97],"tumor":[9],"necrosis":[10],"factor-\u03b1":[11],"(TNF-\u03b1)":[12],"and":[13,53,56],"the":[14],"protective":[15,90],"effects":[16,91],"of":[17],"carvedilol":[18,41,74],"on":[19,92],"it.":[20],"METHODS:":[21],"1-3":[22],"days":[23],"SD":[24],"rats":[25],"were":[28],"divided":[29],"into":[30],"three":[31],"groups:":[32],"control":[33,68],"group:":[34,38,42],"DMEM;":[36],"TNF-\u03b1":[37,60,82],"DMEM+TNF-\u03b1;":[40],"DMEM+TNF-\u03b1":[44],"+":[45],"carvedilol.":[46],"We":[47],"analyzed":[48],"cell":[49],"TUNEL":[52],"electron":[54],"microscope":[55],"flowcytometry.":[57],"RESULTS:":[58],"In":[59],"group,":[61,75],"apoptotic":[62,76],"cardiomyocyte":[63,77],"increased":[64],"apparently":[65],"compared":[66,80],"with":[67,81],"group":[69,83],"\ue006(P":[70,84],"0.01).\ue006":[71],"But":[72],"in":[73],"decreased":[78],"obviously":[79],"0.01).":[85],"\ue006CONCLUSIONS[WTBZ]:":[86],"Carvedilol":[87],"has":[88],"good":[89],"TNF-\u03b1.":[98]},"counts_by_year":[],"updated_date":"2026-08-27T14:10:00.468798","created_date":"2016-06-24T00:00:00"}