{"id":"https://openalex.org/W234893549","doi":null,"title":"OXYGEN DELIVERY-UTILIZATION MATCHING IN SKELETAL MUSCLE by","display_name":"OXYGEN DELIVERY-UTILIZATION MATCHING IN SKELETAL MUSCLE by","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W234893549","mag":"234893549"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.917.3370","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.917.3370","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://krex.k-state.edu/dspace/bitstream/handle/2097/15066/DanielHirai2012.pdf%3Bjsessionid%3DF09664AF19B9D948A1BDF56A3FC8AA39?sequence%3D1","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071657250","display_name":"Daniel M. Hirai","orcid":"https://orcid.org/0000-0002-7861-637X","observed_orcids":["https://orcid.org/0000-0002-7861-637X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel Muller Hirai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"B. Sc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. Sc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071657250"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03059713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-bioavailability","display_name":"nitric oxide bioavailability","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.828000009059906},{"id":"https://openalex.org/keywords/l-name","display_name":"L-NAME","score":0.9340000152587891},{"id":"https://openalex.org/keywords/neuronal-nitric-oxide-synthase","display_name":"neuronal nitric oxide synthase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/s-methyl-l-thiocitrulline","display_name":"S-methyl-L-thiocitrulline","score":0.9380000233650208},{"id":"https://openalex.org/keywords/spinotrapezius-muscle","display_name":"spinotrapezius muscle","score":0.9020000100135803},{"id":"https://openalex.org/keywords/exercise-intolerance","display_name":"exercise intolerance","score":0.6639999747276306},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2994142871","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen delivery","level":3,"score":0.7657464742660522},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6108908653259277},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4253895878791809},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.4250933527946472},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3479539453983307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2747947573661804},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16594380140304565},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09984937310218811},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.917.3370","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.917.3370","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://krex.k-state.edu/dspace/bitstream/handle/2097/15066/DanielHirai2012.pdf%3Bjsessionid%3DF09664AF19B9D948A1BDF56A3FC8AA39?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:krex.k-state.edu:2097/15066","doi":null,"is_oa":false,"landing_page_url":"https://krex.k-state.edu/bitstreams/ad799744-c8df-4b53-98c9-913b11f3e5f7/download","pdf_url":null,"source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":224,"referenced_works":["https://openalex.org/W27929289","https://openalex.org/W116684383","https://openalex.org/W154549817","https://openalex.org/W623886000","https://openalex.org/W954944586","https://openalex.org/W1481335435","https://openalex.org/W1492157034","https://openalex.org/W1496671849","https://openalex.org/W1499355707","https://openalex.org/W1511189929","https://openalex.org/W1524842621","https://openalex.org/W1528220495","https://openalex.org/W1531919570","https://openalex.org/W1541276119","https://openalex.org/W1565656270","https://openalex.org/W1575561688","https://openalex.org/W1580052517","https://openalex.org/W1607286095","https://openalex.org/W1785268013","https://openalex.org/W1797124606","https://openalex.org/W1844317142","https://openalex.org/W1844957509","https://openalex.org/W1860472154","https://openalex.org/W1867229320","https://openalex.org/W1885067579","https://openalex.org/W1889843409","https://openalex.org/W1893160504","https://openalex.org/W1914380123","https://openalex.org/W1919315131","https://openalex.org/W1948975945","https://openalex.org/W1957992664","https://openalex.org/W1970705991","https://openalex.org/W1972327413","https://openalex.org/W1973687183","https://openalex.org/W1974004829","https://openalex.org/W1974971631","https://openalex.org/W1975288614","https://openalex.org/W1977500661","https://openalex.org/W1977510498","https://openalex.org/W1978043203","https://openalex.org/W1982282544","https://openalex.org/W1983341440","https://openalex.org/W1983439620","https://openalex.org/W1983677081","https://openalex.org/W1984396722","https://openalex.org/W1985883345","https://openalex.org/W1986547603","https://openalex.org/W1986886094","https://openalex.org/W1987160301","https://openalex.org/W1987981231","https://openalex.org/W1989852151","https://openalex.org/W1990202173","https://openalex.org/W1990665368","https://openalex.org/W1991209451","https://openalex.org/W1991295172","https://openalex.org/W1993113186","https://openalex.org/W1997177813","https://openalex.org/W1998954481","https://openalex.org/W2001292782","https://openalex.org/W2004639742","https://openalex.org/W2004715700","https://openalex.org/W2005602619","https://openalex.org/W2005672567","https://openalex.org/W2006599075","https://openalex.org/W2006854790","https://openalex.org/W2007405130","https://openalex.org/W2008579796","https://openalex.org/W2008793473","https://openalex.org/W2009372606","https://openalex.org/W2009817860","https://openalex.org/W2010469212","https://openalex.org/W2010917138","https://openalex.org/W2011480706","https://openalex.org/W2014374142","https://openalex.org/W2016378441","https://openalex.org/W2016589481","https://openalex.org/W2018108564","https://openalex.org/W2019700325","https://openalex.org/W2022295123","https://openalex.org/W2023853573","https://openalex.org/W2024360437","https://openalex.org/W2025854468","https://openalex.org/W2030962213","https://openalex.org/W2033484785","https://openalex.org/W2034401446","https://openalex.org/W2035346726","https://openalex.org/W2036596655","https://openalex.org/W2036765113","https://openalex.org/W2037365395","https://openalex.org/W2037854429","https://openalex.org/W2038865497","https://openalex.org/W2038971362","https://openalex.org/W2039387002","https://openalex.org/W2040559102","https://openalex.org/W2041672171","https://openalex.org/W2042054187","https://openalex.org/W2043035405","https://openalex.org/W2046690044","https://openalex.org/W2047548692","https://openalex.org/W2052928078","https://openalex.org/W2054475834","https://openalex.org/W2055207018","https://openalex.org/W2058687959","https://openalex.org/W2058853462","https://openalex.org/W2059383552","https://openalex.org/W2063775163","https://openalex.org/W2063807337","https://openalex.org/W2066072108","https://openalex.org/W2067632283","https://openalex.org/W2071186420","https://openalex.org/W2071621393","https://openalex.org/W2072882401","https://openalex.org/W2073555892","https://openalex.org/W2074166264","https://openalex.org/W2074939086","https://openalex.org/W2074967524","https://openalex.org/W2076304297","https://openalex.org/W2079057437","https://openalex.org/W2082144305","https://openalex.org/W2085351918","https://openalex.org/W2087309105","https://openalex.org/W2088661471","https://openalex.org/W2089665132","https://openalex.org/W2089945473","https://openalex.org/W2093071893","https://openalex.org/W2093518775","https://openalex.org/W2093688503","https://openalex.org/W2094866017","https://openalex.org/W2094914028","https://openalex.org/W2096668802","https://openalex.org/W2096995613","https://openalex.org/W2098189850","https://openalex.org/W2099375619","https://openalex.org/W2100626759","https://openalex.org/W2101120266","https://openalex.org/W2101164971","https://openalex.org/W2101444644","https://openalex.org/W2101861123","https://openalex.org/W2102335665","https://openalex.org/W2102874450","https://openalex.org/W2103266410","https://openalex.org/W2103716936","https://openalex.org/W2104585093","https://openalex.org/W2106052969","https://openalex.org/W2107621770","https://openalex.org/W2108339487","https://openalex.org/W2109319605","https://openalex.org/W2109560819","https://openalex.org/W2109919392","https://openalex.org/W2111880775","https://openalex.org/W2113529945","https://openalex.org/W2113766731","https://openalex.org/W2113820431","https://openalex.org/W2114196384","https://openalex.org/W2114664721","https://openalex.org/W2115781988","https://openalex.org/W2116127384","https://openalex.org/W2117309406","https://openalex.org/W2117389490","https://openalex.org/W2118529914","https://openalex.org/W2119114877","https://openalex.org/W2119504244","https://openalex.org/W2120761745","https://openalex.org/W2123492361","https://openalex.org/W2125596305","https://openalex.org/W2126067755","https://openalex.org/W2129091614","https://openalex.org/W2129739017","https://openalex.org/W2130102177","https://openalex.org/W2130140191","https://openalex.org/W2131794365","https://openalex.org/W2133244276","https://openalex.org/W2133309314","https://openalex.org/W2134224248","https://openalex.org/W2135290404","https://openalex.org/W2135609788","https://openalex.org/W2135704180","https://openalex.org/W2136301623","https://openalex.org/W2137244712","https://openalex.org/W2137387222","https://openalex.org/W2142483199","https://openalex.org/W2146056013","https://openalex.org/W2152928341","https://openalex.org/W2154375091","https://openalex.org/W2155197781","https://openalex.org/W2156172044","https://openalex.org/W2156265674","https://openalex.org/W2156817199","https://openalex.org/W2158137737","https://openalex.org/W2158214634","https://openalex.org/W2160615772","https://openalex.org/W2161949572","https://openalex.org/W2162161355","https://openalex.org/W2163898336","https://openalex.org/W2165366402","https://openalex.org/W2167102952","https://openalex.org/W2169693638","https://openalex.org/W2170027368","https://openalex.org/W2172218838","https://openalex.org/W2184796864","https://openalex.org/W2212093853","https://openalex.org/W2227174102","https://openalex.org/W2234733724","https://openalex.org/W2240115711","https://openalex.org/W2277160997","https://openalex.org/W2279317831","https://openalex.org/W2287732602","https://openalex.org/W2289643233","https://openalex.org/W2307876399","https://openalex.org/W2309805637","https://openalex.org/W2324054422","https://openalex.org/W2328279966","https://openalex.org/W2340972511","https://openalex.org/W2395238698","https://openalex.org/W2402305890","https://openalex.org/W2403855204","https://openalex.org/W2404103831","https://openalex.org/W2405350346","https://openalex.org/W2412377394","https://openalex.org/W2423810330","https://openalex.org/W2426138182","https://openalex.org/W2438313479","https://openalex.org/W3173410773","https://openalex.org/W3177158708"],"related_works":["https://openalex.org/W2897489926","https://openalex.org/W3006407004","https://openalex.org/W2496416646","https://openalex.org/W2745966479","https://openalex.org/W2615993839","https://openalex.org/W2217522680","https://openalex.org/W2745274276","https://openalex.org/W3028233929","https://openalex.org/W2273952393","https://openalex.org/W3014952891"],"abstract_inverted_index":{"The":[0,52],"overall":[1],"aim":[2],"of":[3,28,55,81,122,131,146,197,214,310,333],"this":[4,56,160],"dissertation":[5,57],"is":[6,23,171],"to":[7,156,190],"better":[8],"understand":[9],"the":[10,26,39,77,88,111,119,132,186,194,237,287,308,322],"mechanisms":[11],"determining":[12],"skeletal":[13,71,147,206,225,291,314],"muscle":[14,35,72,108,121,148,207,226,263,292,315],"oxygen":[15,45,212,293,323],"delivery-utilization":[16],"matching":[17],"in":[18,33,49,63,118,143,159,173,178,185,193,245,271,279,300],"health":[19,301],"and":[20,79,113,180,199,232,267,273,295,302],"disease.":[21,303],"Emphasis":[22],"directed":[24],"toward":[25],"role":[27],"nitric":[29],"oxide":[30],"(NO)":[31],"bioavailability":[32,65,281],"modulating":[34],"microvascular":[36,227,264,316],"oxygenation":[37,228,265],"(PO2mv;":[38],"sole":[40],"driving":[41],"force":[42,215],"for":[43],"blood-myocyte":[44],"flux)":[46],"during":[47,114],"transitions":[48],"metabolic":[50,238],"demand.":[51],"first":[53],"investigation":[54],"(Chapter":[58],"2)":[59],"demonstrates":[60,219],"that":[61,153,167,220,256],"alterations":[62,142,278],"NO":[64,85,89,97,134,280],"have":[66,282],"a":[67,283,327],"major":[68,284],"impact":[69,285],"on":[70,205,286,321],"PO2mv":[73,109,149,231,234,298],"kinetics":[74],"following":[75],"both":[76],"onset":[78,112],"cessation":[80],"contractions.":[82],"Specifically,":[83],"increased":[84],"levels":[86,98,191],"(via":[87],"donor":[90],"sodium":[91],"nitroprusside;":[92],"SNP)":[93],"elevates":[94],"whereas":[95],"reduced":[96],"(non-specific":[99],"NOS":[100],"inhibition":[101,130],"with":[102,127,150],"NG-nitro-L-arginine":[103],"methyl":[104],"ester;":[105],"L-NAME)":[106],"diminishes":[107],"at":[110],"recovery":[115],"from":[116],"contractions":[117],"spinotrapezius":[120],"healthy":[123,246],"young":[124,247],"rats.":[125],"Consistent":[126],"these":[128,174,335],"results,":[129],"neuronal":[133],"synthase":[135],"isoform":[136],"(S-methyl-L-thiocitrulline;":[137],"SMTC;":[138],"Chapter":[139,163,217],"3)":[140],"reveals":[141],"NO-mediated":[144,243,261],"regulation":[145],"advanced":[151,305],"age":[152,306],"likely":[154],"contribute":[155],"exercise":[157,222,257,269,318],"intolerance":[158,270],"population.":[161],"In":[162,276],"4":[164],"we":[165],"observed":[166],"pronounced":[168],"oxidative":[169],"stress":[170],"implicated":[172],"pathological":[175],"responses":[176],"seen":[177,192],"aged":[179,272],"diseased":[181,274],"states.":[182],"Transient":[183],"elevations":[184],"oxidant":[187],"hydrogen":[188],"peroxide":[189],"early":[195],"stages":[196],"senescence":[198],"cardiovascular":[200],"diseases":[201],"promote":[202],"detrimental":[203],"effects":[204],"contractile":[208],"function":[209,244],"(i.e.,":[210,229,297],"augmented":[211],"cost":[213],"production).":[216],"5":[218],"endurance":[221],"training":[223,258],"improves":[224],"greater":[230],"slower":[233],"kinetics)":[235,299],"across":[236],"transient":[239],"partly":[240],"via":[241],"enhanced":[242],"individuals.":[248],"These":[249],"data":[250],"carry":[251],"important":[252],"clinical":[253],"implications":[254],"given":[255],"may":[259],"ameliorate":[260],"function,":[262],"deficits":[266],"consequently":[268],"populations.":[275],"conclusion,":[277],"dynamic":[288],"balance":[289],"between":[290],"delivery":[294],"utilization":[296],"While":[304],"or":[307],"predations":[309],"disease":[311],"impair":[312],"considerably":[313],"oxygenation,":[317],"training-induced":[319],"adaptations":[320],"transport":[324],"system":[325],"constitute":[326],"non-pharmacological":[328],"therapeutic":[329],"intervention":[330],"potentially":[331],"capable":[332],"mitigating":[334],"microcirculatory":[336],"deficits.":[337]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-10-10T00:00:00"}