{"id":"https://openalex.org/W2348836768","doi":null,"title":"Altered expression of organic anion transporters and its significance in kidney disease states","display_name":"Altered expression of organic anion transporters and its significance in kidney disease states","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2348836768","mag":"2348836768"},"language":"en","primary_location":{"id":"mag:2348836768","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWLK200708018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764720353","display_name":"International Journal of Internal Medicine","issn_l":"2326-1064","issn":["2326-1064","2326-1072"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Internal Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100302767","display_name":"YU Xue-qin","orcid":"https://orcid.org/0009-0005-3452-6574","observed_orcids":["https://orcid.org/0009-0005-3452-6574"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"YU Xue-qin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100302767"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2909052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organic-anion-transporters","display_name":"organic anion transporters","score":1.0},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.7689999938011169},{"id":"https://openalex.org/keywords/proximal-tubule","display_name":"proximal tubule","score":0.9110000133514404},{"id":"https://openalex.org/keywords/uremic-toxins","display_name":"uremic toxins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/drug-excretion","display_name":"drug excretion","score":0.7390000224113464},{"id":"https://openalex.org/keywords/environmental-chemicals","display_name":"environmental chemicals","score":0.628000020980835},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.47099998593330383},{"id":"https://openalex.org/keywords/renal-tubular-transport","display_name":"renal tubular transport","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C123584848","wikidata":"https://www.wikidata.org/wiki/Q18034026","display_name":"Organic anion transporter 1","level":4,"score":0.8326239585876465},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.6963965892791748},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6497583389282227},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.6373063325881958},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.532223105430603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5004498958587646},{"id":"https://openalex.org/C121421483","wikidata":"https://www.wikidata.org/wiki/Q43457632","display_name":"Organic anion","level":3,"score":0.45021185278892517},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4340782165527344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3437322974205017},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33380070328712463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3243447244167328},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2927749752998352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28999316692352295},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24558526277542114},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.14901500940322876},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06920644640922546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2348836768","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-GWLK200708018.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764720353","display_name":"International Journal of Internal Medicine","issn_l":"2326-1064","issn":["2326-1064","2326-1072"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Internal Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767729888","https://openalex.org/W2122764045","https://openalex.org/W2339862143","https://openalex.org/W2073263307","https://openalex.org/W2061798737","https://openalex.org/W2011100509","https://openalex.org/W2046824019","https://openalex.org/W3047531688","https://openalex.org/W2393813588","https://openalex.org/W2124824529"],"abstract_inverted_index":{"Organic":[0],"anion":[1],"transporters(OATs)play":[2],"a":[3],"critical":[4],"role":[5],"in":[6,56,71,78,88],"the":[7,17,23,50,72],"elimination":[8],"of":[9,25,43,52,74],"numerous":[10],"endogenous":[11,37],"and":[12,36,60,68,82,86],"exogenous":[13,27],"organic":[14,28,38],"anions":[15,29,39],"from":[16],"body.The":[18],"renal":[19,79],"OATs":[20,53],"contribute":[21],"to":[22],"excretion":[24],"many":[26,41],"such":[30],"as":[31],"drugs,numerous":[32],"environmental":[33],"chemicals,biological":[34],"toxin":[35],"including":[40],"kinds":[42],"uremic":[44],"toxin.Recently,several":[45],"studies":[46],"have":[47],"indicated":[48],"that":[49],"expressions":[51],"are":[54,91],"affected":[55],"various":[57],"kidney":[58],"diseases":[59],"cause":[61],"consequent":[62],"pathophysiolgical":[63],"effects.In":[64],"this":[65],"review,current":[66],"knowledge":[67],"recent":[69],"progress":[70],"understanding":[73],"OATs'":[75],"biological":[76],"characteristics":[77],"proximal":[80],"tubular":[81],"its'":[83],"expression":[84],"change":[85],"significance":[87],"disease":[89],"states":[90],"discussed.":[92]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}