{"id":"https://openalex.org/W2348701802","doi":null,"title":"[Association of interleukin-1 gene polymorphism with gastric cancer in a high-risk area of China].","display_name":"[Association of interleukin-1 gene polymorphism with gastric cancer in a high-risk area of China].","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2348701802","mag":"2348701802","pmid":"https://pubmed.ncbi.nlm.nih.gov/15485792"},"language":"zh","primary_location":{"id":"pmid:15485792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15485792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101638093","display_name":"Sheng Hu","orcid":"https://orcid.org/0000-0001-6046-3478","observed_orcids":["https://orcid.org/0000-0001-6046-3478"]},"institutions":[{"id":"https://openalex.org/I4210160841","display_name":"Hubei Cancer Hospital","ror":"https://ror.org/05p38yh32","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160841"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Hu","raw_affiliation_strings":["Oncology Hospital of Hubei Province, Wuhan 430079, China. ehusmn@yahoo.com.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Hospital of Hubei Province, Wuhan 430079, China. ehusmn@yahoo.com.cn","institution_ids":["https://openalex.org/I4210160841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102201896","display_name":"Qibin Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qi-bin Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074819285","display_name":"Ding Yu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ding Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103666520","display_name":"Yu-hua Ke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu-hua Ke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034408535","display_name":"Pin-jing Hu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pin-jing Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103442003","display_name":"Zhirong Zeng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhi-rong Zeng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7219,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.73019227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"24","issue":"10","first_page":"1171","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7870000004768372},{"id":"https://openalex.org/keywords/interleukin-1-gene-polymorphisms","display_name":"interleukin-1 gene polymorphisms","score":0.9359999895095825},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.7599999904632568},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.968999981880188},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.781000018119812},{"id":"https://openalex.org/keywords/high-risk-areas","display_name":"high-risk areas","score":0.6129999756813049},{"id":"https://openalex.org/keywords/shaanxi","display_name":"Shaanxi","score":0.8309999704360962},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.367000013589859}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7593681812286377},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5699388980865479},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5278651118278503},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.5198674201965332},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5137146711349487},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5040079951286316},{"id":"https://openalex.org/C17757408","wikidata":"https://www.wikidata.org/wiki/Q4135516","display_name":"genomic DNA","level":3,"score":0.4697449803352356},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.45694124698638916},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.4536950886249542},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.4412718415260315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40287771821022034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3840448260307312},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35024362802505493},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3463529944419861},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3356602191925049},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.09571534395217896}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012494","descriptor_name":"Sampling Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15485792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15485792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA","raw_type":"English Abstract"},{"id":"mag:2348701802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15485792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2361688097","https://openalex.org/W2348578664","https://openalex.org/W2371135766","https://openalex.org/W2353550122","https://openalex.org/W2031327305","https://openalex.org/W2159449545","https://openalex.org/W2382141756","https://openalex.org/W2369758319","https://openalex.org/W2071357805","https://openalex.org/W2388792819"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,6,44,109],"difference":[4],"in":[5,25,56,75,114],"frequencies":[7,72],"of":[8,32,35,47,73,111],"interleukin-1B":[9],"(IL-1)":[10],"+3954,":[11,76],"-511,":[12,77],"-31":[13,78],"and":[14,22,51,79,88,96],"IL-1RN":[15,80],"gene":[16,102],"polymorphism":[17,67,103],"between":[18,84],"gastric":[19,33,53,85,112],"cancer":[20,34,54,86,113],"patients":[21,55,87],"normal":[23,49,89],"subjects":[24,50,90],"Shaanxi":[26,57],"Province,":[27],"a":[28],"high":[29],"risk":[30,110],"area":[31],"China.":[36],"METHODS:":[37],"The":[38],"genomic":[39],"DNA":[40],"was":[41],"extracted":[42],"from":[43],"peripheral":[45],"blood":[46],"169":[48],"86":[52],"Province.":[58],"IL-1":[59,74,101],"polymorphisms":[60],"were":[61,82],"analyzed":[62],"using":[63],"PCR-restriction":[64],"fragment":[65],"length":[66],"(PCR-RFLP).":[68],"RESULTS:":[69],"T/T":[70],"genotype":[71],"loci":[81],"similar":[83],"(x(2)":[91],"=":[92],"0,":[93,97],"0.04,":[94],"0.3":[95],"P>0.05,":[98],"respectively).":[99],"CONCLUSION:":[100],"may":[104],"be":[105],"not":[106],"associated":[107],"with":[108],"this":[115],"high-risk":[116],"area.":[117]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2016-06-24T00:00:00"}