{"id":"https://openalex.org/W2348587804","doi":null,"title":"Effect of celecoxib on proliferation of KB/VCR cell lines resistant to vincristine and its mechanism","display_name":"Effect of celecoxib on proliferation of KB/VCR cell lines resistant to vincristine and its mechanism","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2348587804","mag":"2348587804"},"language":"en","primary_location":{"id":"mag:2348587804","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-QLZL201123005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764348286","display_name":"Zhonghua zhongliu fangzhi zazhi","issn_l":"1673-5269","issn":["1673-5269"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323238127","host_organization_name":"Zhonghua Zhong liu Fang Zhi za Zhi","host_organization_lineage":["https://openalex.org/P4323238127"],"host_organization_lineage_names":["Zhonghua Zhong liu Fang Zhi za Zhi"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua zhongliu fangzhi zazhi","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027145422","display_name":"Weizhong Li","orcid":"https://orcid.org/0000-0003-1804-9403","observed_orcids":["https://orcid.org/0000-0003-1804-9403"]},"institutions":[{"id":"https://openalex.org/I4210103346","display_name":"Nanfang Hospital","ror":"https://ror.org/01eq10738","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210103346"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weizhong Li","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery,Nanfang Hospital,Southern Medical University, Guangzhou 510515,P"],"raw_orcid":"https://orcid.org/0000-0003-1804-9403","affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery,Nanfang Hospital,Southern Medical University, Guangzhou 510515,P","institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027145422"],"corresponding_institution_ids":["https://openalex.org/I4210103346","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26220259,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/celecoxib","display_name":"celecoxib","score":1.0},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9520000219345093},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8370000123977661},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cox-2-inhibitors","display_name":"COX-2 inhibitors","score":0.7919999957084656},{"id":"https://openalex.org/keywords/drug-accumulation","display_name":"drug accumulation","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5929999947547913},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2776467144","wikidata":"https://www.wikidata.org/wiki/Q408801","display_name":"Celecoxib","level":2,"score":0.9921550750732422},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.6961102485656738},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5125896334648132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5012500286102295},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4812288284301758},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.471521258354187},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.458077609539032},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3444667160511017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2715460956096649},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.15133130550384521},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14484649896621704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1305626630783081},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1176626980304718},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07727649807929993}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2348587804","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-QLZL201123005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764348286","display_name":"Zhonghua zhongliu fangzhi zazhi","issn_l":"1673-5269","issn":["1673-5269"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4323238127","host_organization_name":"Zhonghua Zhong liu Fang Zhi za Zhi","host_organization_lineage":["https://openalex.org/P4323238127"],"host_organization_lineage_names":["Zhonghua Zhong liu Fang Zhi za Zhi"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua zhongliu fangzhi zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2409205014","https://openalex.org/W2092991902","https://openalex.org/W2359760977","https://openalex.org/W2530613732","https://openalex.org/W1983364111","https://openalex.org/W2067788438","https://openalex.org/W2383572542","https://openalex.org/W1979529597","https://openalex.org/W2376564945","https://openalex.org/W2114939751"],"abstract_inverted_index":{"OBJECTIVE:To":[0],"investigate":[1],"the":[2,8,14,19,45,58,67,146,157,162,167],"influence":[3],"of":[4,10,16,21,48,60,69,78,99,123,148,159,164,169],"celecoxib,COX-2":[5],"selective":[6],"inhibitor,upon":[7],"proliferation":[9],"KB/VCR":[11,23,51,73,79,151,173],"cells,and":[12],"analyze":[13],"effect":[15,47],"celecoxib":[17,35,49,84,95,102,107,128,131,160],"on":[18,50,161],"expression":[20,59,98,163],"P-glycoprotein(P-gp).METHODS:The":[22],"cells":[24,80],"were":[25,30,109,133],"divided":[26],"into":[27],"4":[28],"groups,which":[29],"vincristine(VCR)":[31],"group,celecoxib":[32],"group,VCR":[33],"plus":[34,83,106,127],"group":[36,85,93,103,108,116,129,132,140],"and":[37,94,104,117,130,141],"control":[38,115,139],"group.MTT":[39],"method":[40],"was":[41,54,63,86],"employed":[42,55],"to":[43,56,65],"study":[44],"inhibition":[46,76],"cells.Western":[52],"blot":[53],"detect":[57],"P-gp.Flow":[61],"cytometry":[62],"used":[64],"evaluate":[66],"amount":[68,168],"Rho123":[70,124],"accumulated":[71,171],"in":[72,81,91,101,114,125,138,172],"cells.RESULTS:The":[74],"growth":[75],"rate":[77],"VCR":[82,92,105,118,126,142,149,170],"significantly":[87,134],"higher":[88,135],"than":[89,136],"that":[90],"group(all":[96],"P0.01).The":[97],"P-gp":[100],"markedly":[110],"lower,compared":[111],"with":[112,156],"those":[113,137],"group.Meanwhile,the":[119],"intracellular":[120],"fluorescence":[121],"intensity":[122],"group.CONCLUSIONS:Celecoxib":[143],"can":[144],"enhance":[145],"toxicity":[147],"against":[150],"cells.The":[152],"mechanism":[153],"probably":[154],"correlates":[155],"down-regulation":[158],"P-gp,which":[165],"increases":[166],"cells.":[174]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2016-06-24T00:00:00"}