{"id":"https://openalex.org/W2348428835","doi":null,"title":"The costimulatory effect of mouse B7-H3 gene in the activation of T cells","display_name":"The costimulatory effect of mouse B7-H3 gene in the activation of T cells","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2348428835","mag":"2348428835"},"language":"en","primary_location":{"id":"mag:2348428835","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SHMY201101004.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Immunology","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115588092","display_name":"Xueguang Zhang","orcid":"https://orcid.org/0000-0002-3519-4277","observed_orcids":["https://orcid.org/0000-0002-3519-4277","https://orcid.org/0000-0002-8322-1073"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhang Xue-guang","raw_affiliation_strings":["Institute of Biotechnology,Soochow University,2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology,Soochow University,2","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5115588092"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.21944529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7329000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7329000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.19009999930858612,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.009800000116229057,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.996999979019165},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.796999990940094},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9399999976158142},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8880000114440918},{"id":"https://openalex.org/keywords/monoclonal-antibody-blockade","display_name":"monoclonal antibody blockade","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.73361736536026},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.6872908473014832},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6606717705726624},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6513323187828064},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6298319697380066},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.599574863910675},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.519531786441803},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5034968256950378},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47892507910728455},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.4686070680618286},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4354208707809448},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40735045075416565},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2791580855846405},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14449754357337952},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0980394184589386}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2348428835","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SHMY201101004.htm","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Current Immunology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2191971608","https://openalex.org/W2355481742","https://openalex.org/W2110172571","https://openalex.org/W2384099169","https://openalex.org/W1553363554","https://openalex.org/W2048775478","https://openalex.org/W1181094419","https://openalex.org/W3148988787","https://openalex.org/W7095949146","https://openalex.org/W2157646900"],"abstract_inverted_index":{"The":[0],"biological":[1,28,185],"function":[2,29,176],"of":[3,100,102,119,144,150,175,183,187],"mouse":[4,22,38,43,131,137,168],"B7-H3":[5,23,39,132,138],"was":[6,12,54,77,115,133],"still":[7],"not":[8],"identified":[9],"yet.This":[10],"paper":[11],"aimed":[13],"to":[14,25,69,96],"generate":[15],"an":[16],"engineered":[17,167],"CHO":[18,80],"cell":[19,126,170,177],"line":[20,127,171],"harboring":[21],"and":[24,30,48,66,85,91,110,121,148,152],"investigate":[26],"its":[27],"effects":[31],"on":[32,106],"T":[33,107,145],"lymphocyte":[34],"activation.The":[35],"genes":[36],"coding":[37],"were":[40,94],"obtained":[41],"from":[42],"liver":[44],"cDNA":[45],"by":[46,87,117,161],"RT-PCR":[47],"then":[49],"the":[50,71,98,103,130,136,142,166,180,184],"target":[51],"gene":[52],"fragment":[53],"inserted":[55],"into":[56,79],"eukaryotic":[57],"vector":[58,73,76],"pIRES2-EGFP":[59],"after":[60],"being":[61],"digested":[62],"with":[63,82],"EcoR":[64],"\u2160":[65],"Bgl":[67],"\u2161":[68],"construct":[70],"recombinant":[72,75],"pIRES2-EGFP/B7-H3.This":[74],"transfected":[78,104],"cells":[81,105,108,146],"LipfectAMINETM":[83],"2000":[84],"followed":[86],"G418":[88],"selection.RT-PCR,Western":[89],"blotting":[90],"flow":[92],"cytometry(FCM)":[93],"used":[95],"detect":[97],"expression":[99],"B7-H3.Effects":[101],"proliferation":[109,143],"cytokine":[111],"production":[112],"in":[113,147,154],"vitro":[114],"studied":[116],"methods":[118],"CCK8":[120],"ELISA.In":[122],"these":[123],"ways,a":[124],"stable":[125],"constitutively":[128],"expressing":[129],"established":[134],"successfully,and":[135],"could":[139,157],"obviously":[140],"promote":[141],"secretion":[149],"IL-2":[151],"IFN-\u03b3":[153],"vitro.This":[155],"effect":[156],"be":[158],"partly":[159],"blocked":[160],"mAb.It":[162],"is":[163],"evident":[164],"that":[165],"B7-H3/CHO":[169],"provides":[172],"a":[173],"gain":[174],"model":[178],"for":[179],"further":[181],"understanding":[182],"role":[186],"B7-H3.":[188]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}
