{"id":"https://openalex.org/W2348136232","doi":null,"title":"The Role of BRCA1 in DNA DSB Repair Pathway","display_name":"The Role of BRCA1 in DNA DSB Repair Pathway","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2348136232","mag":"2348136232"},"language":"en","primary_location":{"id":"mag:2348136232","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SWHZ201501005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102204436","display_name":"Wu Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wu Xiao","raw_affiliation_strings":["Key Laboratory for Medical Molecular Diagnostics of Guangdong Province"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Medical Molecular Diagnostics of Guangdong Province","institution_ids":["https://openalex.org/I4210098034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102204436"],"corresponding_institution_ids":["https://openalex.org/I4210098034"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14025696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":1.0},{"id":"https://openalex.org/keywords/double-strand-break-repair","display_name":"DNA double-strand break repair","score":0.9440000057220459},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.9369999766349792},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9240000247955322},{"id":"https://openalex.org/keywords/single-strand-annealing","display_name":"single-strand annealing","score":0.8930000066757202},{"id":"https://openalex.org/keywords/alternative-end-joining","display_name":"alternative end-joining","score":0.7179999947547913},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/chromatin-modification","display_name":"chromatin modification","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dna-end-resection","display_name":"DNA end resection","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7045088410377502},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.6669460535049438},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5549423098564148},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.49852514266967773},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4930128753185272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4831254184246063},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4637843370437622},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4445294439792633},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.41813552379608154},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3992556929588318},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37334775924682617},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32546696066856384}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2348136232","doi":null,"is_oa":false,"landing_page_url":"http://en.cnki.com.cn/Article_en/CJFDTOTAL-SWHZ201501005.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2911247321","display_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","issn_l":"1007-7626","issn":["1007-7626"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4324114229","host_organization_name":"Chinese Society of Biochemistry and Molecular Biology","host_organization_lineage":["https://openalex.org/P4324114229"],"host_organization_lineage_names":["Chinese Society of Biochemistry and Molecular Biology"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhongguo shengwu huaxue yu fenzi shengwu xuebao","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1970038285","https://openalex.org/W1975548607","https://openalex.org/W1986866593","https://openalex.org/W1997534905","https://openalex.org/W2000196896","https://openalex.org/W2008177568","https://openalex.org/W2021044341","https://openalex.org/W2021870890","https://openalex.org/W2023185750","https://openalex.org/W2032739040","https://openalex.org/W2035850406","https://openalex.org/W2048839078","https://openalex.org/W2049598883","https://openalex.org/W2060247906","https://openalex.org/W2064551980","https://openalex.org/W2067427915","https://openalex.org/W2069021242","https://openalex.org/W2097457790","https://openalex.org/W2109541017","https://openalex.org/W2109716976","https://openalex.org/W2123215808","https://openalex.org/W2125819717","https://openalex.org/W2128354543","https://openalex.org/W2146204567","https://openalex.org/W2152365838","https://openalex.org/W2156238710","https://openalex.org/W2157899948","https://openalex.org/W2160686876","https://openalex.org/W2326676869"],"related_works":["https://openalex.org/W2163784659","https://openalex.org/W2358710252","https://openalex.org/W2354646343","https://openalex.org/W3171806134","https://openalex.org/W2109361580","https://openalex.org/W2059365987","https://openalex.org/W2011934714","https://openalex.org/W1981191944","https://openalex.org/W2140930673","https://openalex.org/W2969689125"],"abstract_inverted_index":{"Breast":[0],"cancer":[1],"susceptibility":[2],"gene":[3,10],"1(":[4],"BRCA1)":[5],"is":[6,56],"a":[7,77],"tumor":[8],"suppressor":[9],"that":[11,26],"involves":[12],"in":[13,80],"DNA":[14,53],"end":[15],"resection,cell":[16],"cycle":[17],"regulation":[18],"and":[19,35,46,52],"chromatin":[20],"modification,etc.,maintaining":[21],"genomic":[22],"stability.Recent":[23],"research":[24],"suggested":[25,57],"BRCA1":[27,51,75],"can":[28],"promote":[29],"error-free":[30],"repairs":[31,42],"such":[32,43],"as":[33,37,39,44],"HDR":[34],"C-NHEJ":[36],"well":[38],"inhibit":[40],"error-prone":[41],"SSA":[45],"A-EJ.":[47],"The":[48],"interaction":[49],"between":[50],"repairrelated":[54],"proteins":[55],"to":[58],"guide":[59],"DSB":[60,81],"repair.":[61],"However,the":[62],"mechanism":[63],"behind":[64],"has":[65],"been":[66],"remained":[67],"unclear.":[68],"This":[69],"paper":[70],"mainly":[71],"focuses":[72],"on":[73],"how":[74],"plays":[76],"guiding":[78],"role":[79],"repair":[82],"pathways.":[83]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
