{"id":"https://openalex.org/W2347103100","doi":null,"title":"A Pilot Evaluation of p53 Activating Therapy as a Novel Strategy in the Treatment of Acute Myeloid Leukaemia","display_name":"A Pilot Evaluation of p53 Activating Therapy as a Novel Strategy in the Treatment of Acute Myeloid Leukaemia","publication_year":2008,"publication_date":"2008-06-08","ids":{"openalex":"https://openalex.org/W2347103100","mag":"2347103100"},"language":"en","primary_location":{"id":"pmh:oai:bora.uib.no:1956/3226","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/3226","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/1956/3226","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084730548","display_name":"Gurid Ven\u00e5s","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gurid Ven\u00e5s","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084730548"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.09269999712705612,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.925000011920929},{"id":"https://openalex.org/keywords/mdm2-inhibitors","display_name":"MDM2 inhibitors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/nutlin-3","display_name":"Nutlin-3","score":0.996999979019165},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.906000018119812},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mouse-xenograft-model","display_name":"xenograft mouse model","score":0.9139999747276306},{"id":"https://openalex.org/keywords/optical-imaging","display_name":"optical imaging","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2993296363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukaemia","level":2,"score":0.7007664442062378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6461081504821777},{"id":"https://openalex.org/C2993416501","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myeloid leukaemia","level":2,"score":0.49084168672561646},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46460598707199097},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.438009649515152},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36710190773010254}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:bora.uib.no:1956/3226","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/3226","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2347103100","doi":null,"is_oa":false,"landing_page_url":"https://bora.uib.no/handle/1956/3226","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:bora.uib.no:1956/3226","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1956/3226","pdf_url":null,"source":{"id":"https://openalex.org/S7407064446","display_name":"NORA - Norwegian Open Research Archives","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W140845169","https://openalex.org/W1641419369","https://openalex.org/W1650797637","https://openalex.org/W1965399369","https://openalex.org/W1970353405","https://openalex.org/W1991494214","https://openalex.org/W1991811857","https://openalex.org/W1993263392","https://openalex.org/W1994852323","https://openalex.org/W2000816728","https://openalex.org/W2001813972","https://openalex.org/W2007044832","https://openalex.org/W2008887283","https://openalex.org/W2012053348","https://openalex.org/W2015886726","https://openalex.org/W2020808779","https://openalex.org/W2037183626","https://openalex.org/W2041568308","https://openalex.org/W2042704778","https://openalex.org/W2044942890","https://openalex.org/W2049763628","https://openalex.org/W2050243632","https://openalex.org/W2058947924","https://openalex.org/W2062801650","https://openalex.org/W2066264051","https://openalex.org/W2067240980","https://openalex.org/W2068140004","https://openalex.org/W2074570559","https://openalex.org/W2079993210","https://openalex.org/W2086651719","https://openalex.org/W2096638244","https://openalex.org/W2097933346","https://openalex.org/W2099056818","https://openalex.org/W2100494757","https://openalex.org/W2102085111","https://openalex.org/W2107369582","https://openalex.org/W2131541507","https://openalex.org/W2138546316","https://openalex.org/W2149367936","https://openalex.org/W2151439322","https://openalex.org/W2168979257","https://openalex.org/W2185856844","https://openalex.org/W2194757950","https://openalex.org/W2253662961","https://openalex.org/W2274010676","https://openalex.org/W2284010712","https://openalex.org/W2569844665","https://openalex.org/W2764775166","https://openalex.org/W4242138200"],"related_works":["https://openalex.org/W2587502765","https://openalex.org/W1975746053","https://openalex.org/W2524752414","https://openalex.org/W2100494757","https://openalex.org/W2104608023","https://openalex.org/W2154876126","https://openalex.org/W2058769653","https://openalex.org/W1964079616","https://openalex.org/W4224078231","https://openalex.org/W2148213068"],"abstract_inverted_index":{"p53":[0,16,32,59,99,119,144,154,157,212,246,292],"is":[1,52,68,129,171],"a":[2,56,110,130,172,209,233,296],"tumour":[3,168],"suppressor":[4],"protein":[5],"involved":[6],"in":[7,31,34,71,120,159,196,215,227,236,238,267,285,299],"maintenance":[8],"of":[9,12,38,44,49,58,64,76,109,112,118,153,179,262,302],"genomic":[10],"stability":[11],"the":[13,18,45,107,116,137,143,156,263,291,300],"cell.":[14],"Primarily,":[15],"protects":[17],"cell":[19,24,241],"from":[20],"malignant":[21],"transformation":[22],"through":[23],"cycle":[25],"arrest":[26],"and":[27,82,124,155,181,187,220,225,273,282,304],"apoptosis.":[28],"While":[29],"mutations":[30],"occur":[33],"less":[35],"than":[36],"10%":[37],"acute":[39],"myeloid":[40,77],"leukaemia":[41],"(AML),":[42],"over-expression":[43],"main":[46],"negative":[47],"regulator":[48],"p53,":[50,87,165,186,206],"MDM2,":[51],"frequently":[53],"observed,":[54],"representing":[55,93],"mechanism":[57],"silencing.":[60],"Furthermore,":[61],"aberrant":[62],"recruitment":[63],"histone":[65],"deacetylases":[66],"(HDACs)":[67],"also":[69],"seen":[70],"AML,":[72,303],"leading":[73,88],"to":[74,89,142,151,191,217,231,259,278],"block":[75],"differentiation.":[78],"HDACs":[79],"deacetylate":[80],"histones":[81],"transcription":[83,182],"factors":[84,183],"such":[85,184],"as":[86,185,295],"increased":[90],"chromatin":[91,180],"compaction,":[92],"an":[94,193,239],"additional":[95],"means":[96],"for":[97],"silencing":[98],"activity.":[100],"In":[101],"this":[102],"study,":[103],"we":[104],"have":[105],"evaluated":[106],"effect":[108,195,235],"combination":[111,228],"two":[113,200],"drugs":[114],"affecting":[115],"regulation":[117],"AML":[121,197,240,251,280],"cells;":[122],"nutlin-3":[123],"valproic":[125],"acid":[126],"(VPA).":[127],"Nutlin-3":[128,224,272],"non-genotoxic":[131,174,211],"MDM2":[132],"antagonist,":[133],"which":[134],"specifically":[135],"disrupts":[136],"MDM2-p53":[138],"interaction":[139],"by":[140],"binding":[141],"specific":[145],"site":[146],"on":[147],"MDM2.":[148],"This":[149],"leads":[150],"activation":[152,213],"pathway":[158],"cancer":[160],"cells":[161],"with":[162],"wild":[163,244],"type":[164,245],"subsequently":[166],"inhibiting":[167,177],"growth.":[169],"VPA":[170,226,274],"well-tolerated":[173],"HDAC":[175],"inhibitor":[176],"deacetylation":[178],"has":[188],"been":[189],"found":[190,230,277],"show":[192,232],"anti-leukemic":[194],"patients.":[198],"These":[199,287],"therapeutic":[201,265],"compounds":[202],"both":[203],"indirectly":[204],"activate":[205],"thereby":[207],"presenting":[208],"combinational":[210,264],"strategy,":[214],"contrast":[216],"conventional":[218],"chemotherapy":[219],"bone":[221],"marrow":[222],"transplantation.":[223],"was":[229,255,276],"synergistic":[234],"vitro":[237],"line":[242],"expressing":[243],"(MOLM-13).":[247],"An":[248],"imageable":[249],"MOLM-13":[250],"xenograft":[252],"mouse":[253],"model":[254],"then":[256],"successfully":[257],"developed":[258],"enable":[260],"evaluation":[261],"strategy":[266,294],"vivo":[268],"using":[269],"optical":[270],"imaging.":[271],"combined":[275],"delay":[279],"development":[281],"increase":[283],"survival":[284],"vivo.":[286],"pilot":[288],"results":[289],"suggests":[290],"activating":[293],"valuable":[297],"concept":[298],"treatment":[301],"should":[305],"indeed":[306],"be":[307],"further":[308],"evaluated.":[309]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}