{"id":"https://openalex.org/W2346980908","doi":"https://doi.org/10.1152/jn.2001.85.2.986","title":"M\u00fcller Cell Ca2+ Waves Evoked by Purinergic Receptor Agonists in Slices of Rat Retina","display_name":"M\u00fcller Cell Ca2+ Waves Evoked by Purinergic Receptor Agonists in Slices of Rat Retina","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2346980908","doi":"https://doi.org/10.1152/jn.2001.85.2.986","mag":"2346980908","pmid":"https://pubmed.ncbi.nlm.nih.gov/11160528"},"language":"en","primary_location":{"id":"doi:10.1152/jn.2001.85.2.986","doi":"https://doi.org/10.1152/jn.2001.85.2.986","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.2001.85.2.986","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100421703","display_name":"Yang Li","orcid":"https://orcid.org/0000-0003-0777-719X","observed_orcids":["https://orcid.org/0000-0003-0777-719X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011019169","display_name":"Lynne A. Holtzclaw","orcid":"https://orcid.org/0000-0001-5102-8992","observed_orcids":["https://orcid.org/0000-0001-5102-8992"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynne A. Holtzclaw","raw_affiliation_strings":["Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113977290","display_name":"James T. Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Russell","raw_affiliation_strings":["Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7985,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.91505216,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"85","issue":"2","first_page":"986","last_page":"994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-waves","display_name":"calcium waves","score":0.9419999718666077},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.609000027179718},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.7070000171661377},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.8500000238418579},{"id":"https://openalex.org/keywords/p2y1-receptor","display_name":"P2Y1 receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.7590000033378601},{"id":"https://openalex.org/keywords/wave-propagation","display_name":"wave propagation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/regenerative-amplification","display_name":"regenerative amplification","score":0.7300000190734863},{"id":"https://openalex.org/keywords/calcium-release-sites","display_name":"calcium release sites","score":0.6650000214576721},{"id":"https://openalex.org/keywords/retinal-slices","display_name":"retinal slices","score":0.675000011920929},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.6679999828338623}],"concepts":[{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.7996249794960022},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6748987436294556},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6016744375228882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5985918045043945},{"id":"https://openalex.org/C2780019924","wikidata":"https://www.wikidata.org/wiki/Q7120083","display_name":"PPADS","level":4,"score":0.5728546380996704},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.520470142364502},{"id":"https://openalex.org/C2776741303","wikidata":"https://www.wikidata.org/wiki/Q379842","display_name":"Tetrodotoxin","level":2,"score":0.4581294655799866},{"id":"https://openalex.org/C2776182878","wikidata":"https://www.wikidata.org/wiki/Q425946","display_name":"Suramin","level":3,"score":0.4499012231826782},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.42143744230270386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39598172903060913},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3557928204536438},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34345853328704834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34233707189559937},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058913","descriptor_name":"Purinergic Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/jn.2001.85.2.986","doi":"https://doi.org/10.1152/jn.2001.85.2.986","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jn.2001.85.2.986","pdf_url":null,"source":{"id":"https://openalex.org/S142952003","display_name":"Journal of Neurophysiology","issn_l":"0022-3077","issn":["0022-3077","1522-1598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurophysiology","raw_type":"journal-article"},{"id":"pmid:11160528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11160528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurophysiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.536.9844","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.536.9844","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.oucom.ohiou.edu/dbms-li/Publication PDF/Ca2+ muller cell.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W201144505","https://openalex.org/W1572171312","https://openalex.org/W1901485302","https://openalex.org/W1902112862","https://openalex.org/W1961374926","https://openalex.org/W1963647218","https://openalex.org/W1974260260","https://openalex.org/W1979361590","https://openalex.org/W1980235848","https://openalex.org/W1981837661","https://openalex.org/W2000245366","https://openalex.org/W2000314100","https://openalex.org/W2005102741","https://openalex.org/W2006338283","https://openalex.org/W2007263885","https://openalex.org/W2016576099","https://openalex.org/W2020949479","https://openalex.org/W2028675694","https://openalex.org/W2028684902","https://openalex.org/W2032618534","https://openalex.org/W2035058927","https://openalex.org/W2035971243","https://openalex.org/W2044787178","https://openalex.org/W2046353863","https://openalex.org/W2056320600","https://openalex.org/W2059477788","https://openalex.org/W2065843356","https://openalex.org/W2069514755","https://openalex.org/W2087667366","https://openalex.org/W2115972383","https://openalex.org/W2120613443","https://openalex.org/W2125297320","https://openalex.org/W2146262948","https://openalex.org/W2149364264","https://openalex.org/W2152691057","https://openalex.org/W2158972964","https://openalex.org/W2163161737","https://openalex.org/W2403054266","https://openalex.org/W2411545912","https://openalex.org/W2742618151","https://openalex.org/W4211044690","https://openalex.org/W4254432479"],"related_works":["https://openalex.org/W7095381757","https://openalex.org/W2019751678","https://openalex.org/W4294413586","https://openalex.org/W4254432479","https://openalex.org/W1980026136","https://openalex.org/W2528110441","https://openalex.org/W2562059170","https://openalex.org/W2398693955","https://openalex.org/W1965128300","https://openalex.org/W7096506238"],"abstract_inverted_index":{"We":[0],"have":[1],"measured":[2],"agonist":[3],"evoked":[4,179],"Ca2+":[5,51,62,99,113,138,141,155,177,252,270,280],"waves":[6,52,116],"in":[7,10,33,53,118,260,291,296],"M\u00fcller":[8,30,54,77,240,289],"cells":[9,32,78,95,241,259,290],"situ":[11],"within":[12],"freshly":[13],"isolated":[14],"retinal":[15,34],"slices.":[16],"Using":[17],"an":[18,303],"eye":[19],"cup":[20],"dye":[21],"loading":[22],"procedure":[23],"we":[24,237],"were":[25,64,73,124,186,202],"able":[26],"to":[27,66,257],"preferentially":[28],"fill":[29],"glial":[31,89,258],"slices":[35,46],"with":[36,47,88],"calcium":[37],"green.":[38],"Fluorescence":[39],"microscopy":[40],"revealed":[41],"that":[42,130,239,288],"bath":[43],"perfusion":[44],"of":[45,121,146,148,248,251,279],"purinergic":[48,132],"agonists":[49,133],"elicits":[50],"cells,":[55],"which":[56],"propagate":[57],"along":[58],"their":[59,80],"processes.":[60],"These":[61,115,285],"signals":[63,156,178,201],"insensitive":[65],"tetrodotoxin":[67],"(TTX,":[68],"1.0":[69],"microM)":[70,192,208],"pretreatment.":[71],"Cells":[72],"readily":[74,111],"identified":[75],"as":[76,302],"by":[79,84,126,136,180,188,205,211,265],"unique":[81],"morphology":[82],"and":[83,109,151,183,193,197,209,224,235,245,298],"subsequent":[85],"immunocytochemical":[86],"labeling":[87],"fibrillary":[90],"acidic":[91],"protein":[92],"antibodies.":[93],"While":[94],"never":[96],"exhibited":[97],"spontaneous":[98],"oscillations,":[100],"purinoreceptor":[101],"agonists,":[102],"ATP,":[103,181,229],"2":[104,107,158,184,230,232],"MeSATP,":[105,231],"ADP,":[106,182,234],"MeSADP,":[108,233],"adenosine":[110,199],"elicited":[112],"waves.":[114],"persisted":[117],"the":[119,131,198,216,225,243,277,292],"absence":[120],"[Ca2+]o":[122],"but":[123],"abolished":[125,203],"thapsigargin":[127],"pretreatment,":[128],"suggesting":[129],"tested":[134],"act":[135],"releasing":[137],"from":[139],"intracellular":[140],"stores.":[142],"The":[143,176],"rank":[144],"order":[145],"potency":[147],"different":[149],"purines":[150],"pyrimidines":[152],"for":[153,228],"inducing":[154],"was":[157,282],"MeSATP":[159,185],"=":[160,168],"2MeSADP":[161],">":[162,164,172],"ADP":[163],"ATP":[165],">>":[166],"alphabetameATP":[167],"uridine":[169,173],"triphosphate":[170],"(UTP)":[171],"diphosphate":[174],"(UDP).":[175],"inhibited":[187],"reactive":[189],"blue":[190],"(100":[191],"suramin":[194],"(200":[195,207],"microM),":[196],"induced":[200],"only":[204],"3,7-dimethyl-1-propargylxanthine":[206],"not":[210],"1,3-dipropyl-8-(2-amino-4-chlorophenyl)-xanthine)":[212],"or":[213],"8-cyclopentyl-1,3-dipropylxanthine":[214],"at":[215,268],"same":[217],"concentration.":[218],"Based":[219],"on":[220],"these":[221],"pharmacological":[222],"characteristics":[223],"dose-response":[226],"relationships":[227],"adenosine,":[236],"concluded":[238],"express":[242],"P1A2":[244],"P2Y1":[246],"subtypes":[247],"purinoceptors.":[249],"Analysis":[250],"responses":[253],"showed":[254],"that,":[255],"similar":[256],"culture,":[261],"wave":[262],"propagation":[263],"occurred":[264],"regenerative":[266],"amplification":[267,274],"specialized":[269],"release":[271,281],"sites":[272],"(wave":[273],"sites),":[275],"where":[276],"rate":[278],"significantly":[283],"enhanced.":[284],"data":[286],"suggest":[287],"retina":[293],"may":[294,300],"participate":[295],"signaling,":[297],"this":[299],"serve":[301],"extra-neuronal":[304],"signaling":[305],"pathway.":[306]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
