{"id":"https://openalex.org/W2346854449","doi":"https://doi.org/10.1016/j.cyto.2016.05.004","title":"Reduction in circulating level of HMGB-1 following continuous renal replacement therapy in sepsis","display_name":"Reduction in circulating level of HMGB-1 following continuous renal replacement therapy in sepsis","publication_year":2016,"publication_date":"2016-05-06","ids":{"openalex":"https://openalex.org/W2346854449","doi":"https://doi.org/10.1016/j.cyto.2016.05.004","mag":"2346854449","pmid":"https://pubmed.ncbi.nlm.nih.gov/27155819"},"language":"en","primary_location":{"id":"doi:10.1016/j.cyto.2016.05.004","doi":"https://doi.org/10.1016/j.cyto.2016.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2016.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101710451","display_name":"Takuya Ueno","orcid":"https://orcid.org/0009-0004-9938-6480","observed_orcids":["https://orcid.org/0009-0004-9938-6480"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP","US"],"is_corresponding":true,"raw_author_name":"Takuya Ueno","raw_affiliation_strings":["Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: ueno.takuya@mgh.harvard.edu","Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan","Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: ueno.takuya@mgh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210094737"]},{"raw_affiliation_string":"Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4210094737"]},{"raw_affiliation_string":"Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110514500","display_name":"Toshiaki Ikeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiaki Ikeda","raw_affiliation_strings":["Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Critical Care and Emergency Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4210094737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006983397","display_name":"Takayoshi Yokoyama","orcid":"https://orcid.org/0009-0003-1803-4508","observed_orcids":["https://orcid.org/0009-0003-1803-4508"]},"institutions":[{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayoshi Yokoyama","raw_affiliation_strings":["Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan","institution_ids":["https://openalex.org/I4210094737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040114902","display_name":"Yu Kihara","orcid":"https://orcid.org/0000-0001-8942-4464","observed_orcids":["https://orcid.org/0000-0001-8942-4464"]},"institutions":[{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Kihara","raw_affiliation_strings":["Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan","institution_ids":["https://openalex.org/I4210094737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044253082","display_name":"Osamu Konno","orcid":"https://orcid.org/0000-0001-7706-0616","observed_orcids":["https://orcid.org/0000-0001-7706-0616"]},"institutions":[{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Konno","raw_affiliation_strings":["Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan","institution_ids":["https://openalex.org/I4210094737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101797155","display_name":"Yuki Nakamura","orcid":"https://orcid.org/0000-0003-4931-2489","observed_orcids":["https://orcid.org/0000-0003-4931-2489"]},"institutions":[{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Nakamura","raw_affiliation_strings":["Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan","institution_ids":["https://openalex.org/I4210094737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079398725","display_name":"Hitoshi Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094737","display_name":"Tokyo Medical University Hachioji Medical Center","ror":"https://ror.org/00vpv1x26","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094737"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Iwamoto","raw_affiliation_strings":["Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Japan","institution_ids":["https://openalex.org/I4210094737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000181954","display_name":"Tetsunosuke Shimizu","orcid":"https://orcid.org/0000-0002-6953-8226","observed_orcids":["https://orcid.org/0000-0002-6953-8226"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsunosuke Shimizu","raw_affiliation_strings":["Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057759766","display_name":"Martina M. McGrath","orcid":"https://orcid.org/0000-0001-6210-9341","observed_orcids":["https://orcid.org/0000-0001-6210-9341"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martina M. McGrath","raw_affiliation_strings":["Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046964205","display_name":"Anil K. Chandraker","orcid":"https://orcid.org/0000-0001-9729-7717","observed_orcids":["https://orcid.org/0000-0001-9729-7717"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Chandraker","raw_affiliation_strings":["Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101710451"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I4210094737"],"apc_list":{"value":3220,"currency":"USD","value_usd":3220},"apc_paid":null,"fwci":2.4976,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.90292305,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"83","issue":null,"first_page":"206","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.972000002861023},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/septic-shock","display_name":"septic shock","score":0.9929999709129333},{"id":"https://openalex.org/keywords/continuous-renal-replacement-therapy","display_name":"continuous renal replacement therapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/continuous-hemodiafiltration","display_name":"continuous hemodiafiltration","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hemoperfusion","display_name":"hemoperfusion","score":0.8870000243186951},{"id":"https://openalex.org/keywords/endotoxin-removal","display_name":"endotoxin removal","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.7919999957084656},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8069999814033508},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C2781123077","wikidata":"https://www.wikidata.org/wiki/Q3144950","display_name":"Hemoperfusion","level":3,"score":0.9309399127960205},{"id":"https://openalex.org/C2777628635","wikidata":"https://www.wikidata.org/wiki/Q1765564","display_name":"Septic shock","level":3,"score":0.8493276834487915},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8291597366333008},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.7598342895507812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7455105781555176},{"id":"https://openalex.org/C2780026444","wikidata":"https://www.wikidata.org/wiki/Q1088175","display_name":"Polymyxin B","level":3,"score":0.6151095032691956},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5581891536712646},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.552161455154419},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.5419133901596069},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4539090096950531},{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.4421735107898712},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4269160032272339},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3377212882041931},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.1454765796661377},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.11022228002548218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0750192403793335},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017582","descriptor_name":"Renal Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017583","descriptor_name":"Hemodiafiltration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D024243","descriptor_name":"HMGB1 Protein","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cyto.2016.05.004","doi":"https://doi.org/10.1016/j.cyto.2016.05.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cyto.2016.05.004","pdf_url":null,"source":{"id":"https://openalex.org/S70396342","display_name":"Cytokine","issn_l":"1043-4666","issn":["1043-4666","1096-0023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"journal-article"},{"id":"pmid:27155819","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27155819","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytokine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2671470375","display_name":"New Insights of Roles of Dendritic Cells in Transplantation","funder_award_id":"15K15479","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1545128816","https://openalex.org/W1982395306","https://openalex.org/W1985903451","https://openalex.org/W1998599826","https://openalex.org/W2011638883","https://openalex.org/W2013327244","https://openalex.org/W2017750899","https://openalex.org/W2020055141","https://openalex.org/W2020942709","https://openalex.org/W2054107809","https://openalex.org/W2054661014","https://openalex.org/W2062450447","https://openalex.org/W2068866979","https://openalex.org/W2082280258","https://openalex.org/W2094830370","https://openalex.org/W2123255995","https://openalex.org/W2155470233","https://openalex.org/W2160691650","https://openalex.org/W2168722200","https://openalex.org/W2442246762","https://openalex.org/W3023757607"],"related_works":["https://openalex.org/W2067756540","https://openalex.org/W1504677535","https://openalex.org/W1982114976","https://openalex.org/W2202039851","https://openalex.org/W1970839067","https://openalex.org/W1545128816","https://openalex.org/W4324359935","https://openalex.org/W2087203304","https://openalex.org/W110441770","https://openalex.org/W2150099010"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
