{"id":"https://openalex.org/W2346835907","doi":"https://doi.org/10.1159/000445550","title":"Generation of Cardiomyocytes in Pipe-Based Microbioreactor Under Segmented Flow","display_name":"Generation of Cardiomyocytes in Pipe-Based Microbioreactor Under Segmented Flow","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2346835907","doi":"https://doi.org/10.1159/000445550","mag":"2346835907","pmid":"https://pubmed.ncbi.nlm.nih.gov/27160591"},"language":"en","primary_location":{"id":"doi:10.1159/000445550","doi":"https://doi.org/10.1159/000445550","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000445550","pdf_url":"https://karger.com/cpb/article-pdf/38/5/1883/2437147/000445550.pdf","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://karger.com/cpb/article-pdf/38/5/1883/2437147/000445550.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113774902","display_name":"Dimitry Spitkovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dimitry Spitkovsky","raw_affiliation_strings":["Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne,","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112138388","display_name":"Karen Lemke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131196","display_name":"Institute for Bioprocessing and Analytical Measurement Techniques","ror":"https://ror.org/03gnnzc77","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210131196"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karen Lemke","raw_affiliation_strings":["Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany","institution_ids":["https://openalex.org/I4210131196"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tobias F\u00f6rster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131196","display_name":"Institute for Bioprocessing and Analytical Measurement Techniques","ror":"https://ror.org/03gnnzc77","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210131196"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias F\u00f6rster","raw_affiliation_strings":["Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany","institution_ids":["https://openalex.org/I4210131196"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert R\u00f6mer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131196","display_name":"Institute for Bioprocessing and Analytical Measurement Techniques","ror":"https://ror.org/03gnnzc77","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210131196"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert R\u00f6mer","raw_affiliation_strings":["Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany","institution_ids":["https://openalex.org/I4210131196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050904345","display_name":"Stefan Wiedemeier","orcid":"https://orcid.org/0000-0001-8865-7741","observed_orcids":["https://orcid.org/0000-0001-8865-7741"]},"institutions":[{"id":"https://openalex.org/I4210131196","display_name":"Institute for Bioprocessing and Analytical Measurement Techniques","ror":"https://ror.org/03gnnzc77","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210131196"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Wiedemeier","raw_affiliation_strings":["Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany","institution_ids":["https://openalex.org/I4210131196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111628906","display_name":"J\u00fcrgen Hescheler","orcid":"https://orcid.org/0000-0001-7686-6562","observed_orcids":["https://orcid.org/0000-0001-7686-6562"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Hescheler","raw_affiliation_strings":["Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne,","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041404332","display_name":"Agapios Sachinidis","orcid":"https://orcid.org/0000-0003-3054-225X","observed_orcids":["https://orcid.org/0000-0003-3054-225X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Agapios Sachinidis","raw_affiliation_strings":["Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, Cologne,","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005962152","display_name":"Gunter Gastrock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131196","display_name":"Institute for Bioprocessing and Analytical Measurement Techniques","ror":"https://ror.org/03gnnzc77","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210131196"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gunter Gastrock","raw_affiliation_strings":["Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Bioprocessing and Analytical Measurement Techniques e.V., Department of Bioprocess Engineering, Heilbad Heiligenstadt, Germany","institution_ids":["https://openalex.org/I4210131196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1785,"currency":"EUR","value_usd":1925},"apc_paid":{"value":1785,"currency":"EUR","value_usd":1925},"fwci":0.1253,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.42437687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"38","issue":"5","first_page":"1883","last_page":"1896"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.5522000193595886,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.27320000529289246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.08950000256299973,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/segmented-flow","display_name":"segmented flow","score":0.9179999828338623},{"id":"https://openalex.org/keywords/microfluidic-bioreactor","display_name":"microfluidic bioreactor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/embryoid-body-formation","display_name":"embryoid body formation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/egfp-expression","display_name":"EGFP expression","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6463627815246582},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.641257643699646},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5606405138969421},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5152445435523987},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.4629994034767151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4412716031074524},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.44038042426109314},{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.4388399124145508},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4336361885070801},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4299378991127014},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4018239676952362},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36050665378570557},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.2727324068546295},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.25925034284591675},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.24518510699272156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14637738466262817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14216196537017822},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000066450","descriptor_name":"Mouse Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D044085","descriptor_name":"Microfluidics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050991","descriptor_name":"GATA4 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050991","descriptor_name":"GATA4 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1159/000445550","doi":"https://doi.org/10.1159/000445550","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000445550","pdf_url":"https://karger.com/cpb/article-pdf/38/5/1883/2437147/000445550.pdf","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},{"id":"pmid:27160591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27160591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:29003","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/29003/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:doaj.org/article:6bc36670d2b94b9382400bb1f934456e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6bc36670d2b94b9382400bb1f934456e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cellular Physiology and Biochemistry, Vol 38, Iss 5, Pp 1883-1896 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1159/000445550","doi":"https://doi.org/10.1159/000445550","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000445550","pdf_url":"https://karger.com/cpb/article-pdf/38/5/1883/2437147/000445550.pdf","source":{"id":"https://openalex.org/S161399637","display_name":"Cellular Physiology and Biochemistry","issn_l":"1015-8987","issn":["1015-8987","1421-9778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular Physiology and Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8382350805","display_name":"High yield and performance stem cell lab","funder_award_id":"223011","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2346835907.pdf","grobid_xml":"https://content.openalex.org/works/W2346835907.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1484720505","https://openalex.org/W1499500424","https://openalex.org/W1587184261","https://openalex.org/W1965674737","https://openalex.org/W1990953278","https://openalex.org/W2000196225","https://openalex.org/W2006499623","https://openalex.org/W2015815222","https://openalex.org/W2025222636","https://openalex.org/W2025421119","https://openalex.org/W2038538829","https://openalex.org/W2042606838","https://openalex.org/W2045387133","https://openalex.org/W2051897558","https://openalex.org/W2058642135","https://openalex.org/W2067315058","https://openalex.org/W2076159213","https://openalex.org/W2084608346","https://openalex.org/W2088201703","https://openalex.org/W2101857495","https://openalex.org/W2132339849","https://openalex.org/W2136628069","https://openalex.org/W2143751064","https://openalex.org/W2150048579","https://openalex.org/W2155746231","https://openalex.org/W2169663226"],"related_works":["https://openalex.org/W2077276126","https://openalex.org/W2388060745","https://openalex.org/W2028330296","https://openalex.org/W2167308751","https://openalex.org/W2478197167","https://openalex.org/W1976879540","https://openalex.org/W2064908309","https://openalex.org/W2089573053","https://openalex.org/W991512989","https://openalex.org/W2021944346"],"abstract_inverted_index":{"BACKGROUND/AIMS:":[0],"Embryonic":[1],"stem":[2],"(ES)":[3],"cells":[4,21,47,97,115,145],"have":[5],"got":[6],"a":[7,64,153],"broad":[8],"range":[9],"differentiation":[10,13,36],"potential.":[11],"The":[12,113],"is":[14],"initiated":[15],"via":[16],"aggregation":[17],"of":[18,27,48,79,130,143,165,176],"non-differentiated":[19],"ES":[20,101,114],"into":[22,45],"embryoid":[23],"body":[24],"(EB)":[25],"capable":[26],"multi-lineage":[28],"development.":[29],"However":[30],"experimental":[31],"variables":[32],"present":[33,63],"in":[34,117],"standard":[35,154],"techniques":[37],"lead":[38],"to":[39,110,139,152,169],"high":[40],"EB":[41,106],"heterogeneity,":[42],"affecting":[43],"development":[44,164],"the":[46,55,118],"desired":[49],"lineage,":[50],"and":[51,58,85,181],"do":[52],"not":[53],"support":[54],"process":[56,94],"automatization":[57],"scalability.":[59],"METHODS:":[60],"Here":[61],"we":[62],"novel":[65],"pipe":[66],"based":[67,71,157],"microbioreactor":[68],"(PBM)":[69],"setup":[70],"on":[72],"segmented":[73],"flow,":[74],"designed":[75],"for":[76,92,108,123,137,174],"spatial":[77],"maintenance":[78],"temperature,":[80],"nutrition":[81],"supply,":[82],"gas":[83],"supply":[84],"sterility.":[86],"RESULTS:":[87],"We":[88],"verified":[89],"PBM":[90,136,148],"feasibility":[91],"continuous":[93],"generating":[95],"cardiac":[96,144],"starting":[98],"from":[99],"single":[100],"cell":[102],"suspension":[103],"followed":[104],"by":[105],"formation":[107,146],"up":[109,138],"10":[111,140],"days.":[112,141],"used":[116],"study":[119],"were":[120],"genetically":[121],"modified":[122],"cardiac-specific":[124],"EGFP":[125],"expression":[126],"allowing":[127],"optical":[128],"monitoring":[129],"cardiomyocytes":[131,172],"while":[132],"EBs":[133],"remained":[134],"within":[135,147],"Efficiency":[142],"was":[149],"similar":[150],"compared":[151],"hanging":[155],"drop":[156],"protocol.":[158],"CONCLUSION:":[159],"Our":[160],"findings":[161],"ensure":[162],"further":[163],"microfluidic":[166],"bioreactor":[167],"technology":[168],"enable":[170],"robust":[171],"production":[173],"needs":[175],"drug":[177],"screening,":[178],"tissue":[179],"engineering":[180],"other":[182],"applications.":[183]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}