{"id":"https://openalex.org/W2346647397","doi":null,"title":"Validation of the transporter ligand cyanoimipramine as a marker of serotonin innervation density in brain.","display_name":"Validation of the transporter ligand cyanoimipramine as a marker of serotonin innervation density in brain.","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W2346647397","mag":"2346647397","pmid":"https://pubmed.ncbi.nlm.nih.gov/7965165"},"language":"en","primary_location":{"id":"pmid:7965165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7965165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036473548","display_name":"Jean\u2010Paul Soucy","orcid":"https://orcid.org/0000-0001-6979-1259","observed_orcids":["https://orcid.org/0000-0001-6979-1259","https://orcid.org/0000-0002-8422-2326"]},"institutions":[{"id":"https://openalex.org/I4210107362","display_name":"H\u00f4pital Notre-Dame","ror":"https://ror.org/01w7qz648","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210107362","https://openalex.org/I4210139015","https://openalex.org/I4210142730","https://openalex.org/I4405279980"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J P Soucy","raw_affiliation_strings":["D\u00e9partement de M\u00e9decine Nucl\u00e9aire, H\u00f4pital Notre-Dame, Montr\u00e9al, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de M\u00e9decine Nucl\u00e9aire, H\u00f4pital Notre-Dame, Montr\u00e9al, Canada","institution_ids":["https://openalex.org/I4210107362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074820664","display_name":"Francine Lafaille","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Lafaille","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064567221","display_name":"Pierrette Lemoine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Lemoine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000296355","display_name":"Abdelghani Mrini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Mrini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109967375","display_name":"Laurent Descarries","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Descarries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7162,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.66866667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"11","first_page":"1822","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.03139999881386757,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.8939999938011169},{"id":"https://openalex.org/keywords/axonal-varicosities","display_name":"axonal varicosities","score":0.8360000252723694},{"id":"https://openalex.org/keywords/neostriatum","display_name":"neostriatum","score":0.8190000057220459},{"id":"https://openalex.org/keywords/5-7-dihydroxytryptamine-lesion","display_name":"5,7-dihydroxytryptamine lesion","score":0.8759999871253967},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9929999709129333},{"id":"https://openalex.org/keywords/radioligand-binding","display_name":"radioligand binding","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7012423276901245},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6359778642654419},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6125794649124146},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.5705047249794006},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.5657340884208679},{"id":"https://openalex.org/C60592354","wikidata":"https://www.wikidata.org/wiki/Q4914018","display_name":"Binding potential","level":3,"score":0.5060333609580994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4433622360229492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4029029607772827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3908465802669525},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38550862669944763},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3208343982696533},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2752686142921448},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22280645370483398},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13940930366516113},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007099","descriptor_name":"Imipramine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014055","descriptor_name":"Tomography, Emission-Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015899","descriptor_name":"Tomography, Emission-Computed, Single-Photon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7965165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7965165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.323.5604","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.5604","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/35/11/1822.full.pdf","raw_type":"text"},{"id":"mag:2346647397","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7965165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1865839397","https://openalex.org/W1873978593","https://openalex.org/W1980784555","https://openalex.org/W1981009815","https://openalex.org/W1983666519","https://openalex.org/W1989623306","https://openalex.org/W1999031559","https://openalex.org/W1999320578","https://openalex.org/W2002564928","https://openalex.org/W2006094523","https://openalex.org/W2008489590","https://openalex.org/W2012999621","https://openalex.org/W2016191099","https://openalex.org/W2017026915","https://openalex.org/W2024899756","https://openalex.org/W2036939881","https://openalex.org/W2047824855","https://openalex.org/W2049515416","https://openalex.org/W2062293209","https://openalex.org/W2067612804","https://openalex.org/W2072740414","https://openalex.org/W2076907447","https://openalex.org/W2085622756","https://openalex.org/W2086151698","https://openalex.org/W2090658544","https://openalex.org/W2162786497","https://openalex.org/W2164978698","https://openalex.org/W2268377390","https://openalex.org/W2404383981","https://openalex.org/W2412721322","https://openalex.org/W2415485176","https://openalex.org/W2417558964","https://openalex.org/W4406987049"],"related_works":["https://openalex.org/W2163786942","https://openalex.org/W2065359568","https://openalex.org/W2528397373","https://openalex.org/W2041956134","https://openalex.org/W1999031559","https://openalex.org/W2085622756","https://openalex.org/W2284449950","https://openalex.org/W1906659553","https://openalex.org/W2395357584","https://openalex.org/W2065002322"],"abstract_inverted_index":{"UNLABELLED:":[0],"Radiolabeled":[1],"ligands":[2,230],"of":[3,38,48,53,56,67,91,102,112,117,136,142,148,152,164,179],"monoamine":[4,13,235],"transporters":[5],"have":[6],"already":[7],"been":[8],"used":[9],"to":[10,31,158,210,228,231],"visualize":[11],"cerebral":[12],"innervation":[14,181,214],"by":[15,19,44,217],"tissue":[16,185],"autoradiography":[17],"and":[18,46,50,139,186,234],"PET":[20,218],"or":[21,83,191,196,219],"SPECT":[22],"in":[23,64,75,81,88,109,183,215],"vivo.":[24],"METHODS:":[25],"A":[26],"sampling":[27],"technique":[28],"was":[29,156],"developed":[30],"allow":[32],"for":[33],"both":[34],"the":[35,51,54,99,110,134,140,153,162,165],"autoradiographic":[36],"counting":[37],"serotonin":[39],"(5-HT)":[40],"axonal":[41,114],"varicosities,":[42],"labeled":[43],"uptake":[45],"storage":[47],"[3H]5-HT,":[49],"measurement":[52],"binding":[55,104,138,173],"[3H]cyanoimipramine":[57],"([3H]CYI),":[58],"a":[59,125,175,204],"specific":[60,171],"5-HT":[61,93,143,180,194,213,233],"transporter":[62],"ligand,":[63],"adjacent":[65],"slices":[66],"adult":[68],"rat":[69],"neostriatum.":[70],"The":[71,150,221],"experiments":[72],"were":[73],"conducted":[74],"normal,":[76],"decreased":[77],"(after":[78,85],"5,7-dihydroxytryptamine":[79],"lesions":[80,87],"adults)":[82],"increased":[84],"6-hydroxydopamine":[86],"neonates)":[89],"states":[90],"neostriatal":[92],"innervation.":[94],"RESULTS:":[95],"In":[96],"normal":[97],"tissue,":[98],"regional":[100,212],"density":[101,135,182],"[3H]CYI":[103,137,172],"faithfully":[105],"reproduced":[106],"rostrocaudal":[107],"variations":[108],"number":[111,141],"[3H]5-HT-labeled":[113],"varicosities.":[115],"Pairs":[116],"values":[118],"from":[119],"all":[120],"three":[121],"experimental":[122],"groups":[123],"showed":[124],"highly":[126],"significant":[127],"linear":[128],"correlation":[129],"(r":[130],"=":[131],"0.93)":[132],"between":[133],"varicosities":[144],"per":[145],"cubic":[146],"millimeter":[147],"tissue.":[149],"intercept":[151],"regression":[154],"line":[155],"close":[157],"zero;":[159],"this":[160],"confirmed":[161],"selectivity":[163],"ligand.":[166],"CONCLUSION:":[167],"Under":[168],"drug-free":[169],"conditions,":[170],"is":[174,187,200],"good":[176],"quantitative":[177],"index":[178],"brain":[184],"not":[188],"significantly":[189],"up-":[190],"downregulated":[192],"on":[193],"denervation":[195],"hyperinnervation.":[197],"When":[198],"it":[199],"adequately":[201],"labeled,":[202],"such":[203],"ligand":[205],"might":[206],"therefore":[207],"be":[208,226],"appropriate":[209],"quantify":[211,232],"vivo":[216],"SPECT.":[220],"present":[222],"approach":[223],"should":[224],"also":[225],"useful":[227],"select":[229],"systems.":[236]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}