{"id":"https://openalex.org/W2346375348","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.3023","title":"A phase I, first-in-human study of ARGX-110, a monoclonal antibody targeting CD70, a receptor involved in immune escape and tumor growth in patients with solid and hematologic malignancies.","display_name":"A phase I, first-in-human study of ARGX-110, a monoclonal antibody targeting CD70, a receptor involved in immune escape and tumor growth in patients with solid and hematologic malignancies.","publication_year":2014,"publication_date":"2014-05-20","ids":{"openalex":"https://openalex.org/W2346375348","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.3023","mag":"2346375348"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2014.32.15_suppl.3023","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.3023","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.3023","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010064853","display_name":"Ahmad Hussein Awada","orcid":"https://orcid.org/0000-0001-7412-9163","observed_orcids":["https://orcid.org/0000-0001-7412-9163"]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ahmad Awada","raw_affiliation_strings":["Institut Jules Bordet \u2013 Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Jules Bordet \u2013 Universit\u00e9 Libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060388485","display_name":"Christian D. Rolfo","orcid":"https://orcid.org/0000-0002-5109-0267","observed_orcids":["https://orcid.org/0000-0002-5109-0267","https://orcid.org/0000-0002-7860-8417"]},"institutions":[{"id":"https://openalex.org/I4210102047","display_name":"Antwerp University Hospital","ror":"https://ror.org/01hwamj44","country_code":"BE","type":"funder","lineage":["https://openalex.org/I4210102047"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Christian D. Rolfo","raw_affiliation_strings":["University Hospital Antwerp, Edegem, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Antwerp, Edegem, Belgium","institution_ids":["https://openalex.org/I4210102047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043348199","display_name":"Sylvie Rottey","orcid":"https://orcid.org/0000-0003-2060-3725","observed_orcids":["https://orcid.org/0000-0003-2060-3725"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sylvie Rottey","raw_affiliation_strings":["Ghent University Hospital, Ghent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ghent University Hospital, Ghent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090877036","display_name":"Laure Ysebrant de Lendonck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Laure Ysebrant de Lendonck","raw_affiliation_strings":["Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063714660","display_name":"Wilfried Schroyens","orcid":"https://orcid.org/0000-0003-4244-3523","observed_orcids":["https://orcid.org/0000-0003-4244-3523"]},"institutions":[{"id":"https://openalex.org/I4210102047","display_name":"Antwerp University Hospital","ror":"https://ror.org/01hwamj44","country_code":"BE","type":"funder","lineage":["https://openalex.org/I4210102047"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Wilfried A. Schroyens","raw_affiliation_strings":["Antwerp University Hospital, Edegem, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Antwerp University Hospital, Edegem, Belgium","institution_ids":["https://openalex.org/I4210102047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112243427","display_name":"Fritz C. Offner","orcid":"https://orcid.org/0000-0003-4690-3603","observed_orcids":["https://orcid.org/0000-0003-4690-3603"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fritz Offner","raw_affiliation_strings":["Universitair Ziekenhuis Gent, Gent, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitair Ziekenhuis Gent, Gent, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015773919","display_name":"Karen Silence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157284","display_name":"Argenx (Belgium)","ror":"https://ror.org/04spfxf63","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210157284"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karen Silence","raw_affiliation_strings":["arGEN-X BVBA, Zwijnaarde, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"arGEN-X BVBA, Zwijnaarde, Belgium","institution_ids":["https://openalex.org/I4210157284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086777523","display_name":"Torsten Dreier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157284","display_name":"Argenx (Belgium)","ror":"https://ror.org/04spfxf63","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210157284"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Torsten Dreier","raw_affiliation_strings":["arGEN-X BVBA, Zwijnaarde, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"arGEN-X BVBA, Zwijnaarde, Belgium","institution_ids":["https://openalex.org/I4210157284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073344530","display_name":"Mahan Moshir","orcid":"https://orcid.org/0009-0009-0287-1049","observed_orcids":["https://orcid.org/0009-0009-0287-1049"]},"institutions":[{"id":"https://openalex.org/I4210157284","display_name":"Argenx (Belgium)","ror":"https://ror.org/04spfxf63","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210157284"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mahan Moshir","raw_affiliation_strings":["arGEN-X BVBA, Zwijnaarde, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"arGEN-X BVBA, Zwijnaarde, Belgium","institution_ids":["https://openalex.org/I4210157284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062770314","display_name":"Hans de Haard","orcid":"https://orcid.org/0000-0001-8707-0084","observed_orcids":["https://orcid.org/0000-0001-8707-0084"]},"institutions":[{"id":"https://openalex.org/I4210157284","display_name":"Argenx (Belgium)","ror":"https://ror.org/04spfxf63","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210157284"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hans de Haard","raw_affiliation_strings":["arGEN-X BVBA, Zwijnaarde, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"arGEN-X BVBA, Zwijnaarde, Belgium","institution_ids":["https://openalex.org/I4210157284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024390084","display_name":"Marc Peeters","orcid":"https://orcid.org/0000-0003-4969-2303","observed_orcids":["https://orcid.org/0000-0003-4969-2303"]},"institutions":[{"id":"https://openalex.org/I4210102047","display_name":"Antwerp University Hospital","ror":"https://ror.org/01hwamj44","country_code":"BE","type":"funder","lineage":["https://openalex.org/I4210102047"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marc Peeters","raw_affiliation_strings":["UZ Antwerpen, Edegem, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UZ Antwerpen, Edegem, Belgium","institution_ids":["https://openalex.org/I4210102047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050300241","display_name":"D Bron","orcid":"https://orcid.org/0000-0002-1634-1104","observed_orcids":["https://orcid.org/0000-0002-1634-1104"]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dominique Bron","raw_affiliation_strings":["Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019216062","display_name":"Alain Thibault","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157284","display_name":"Argenx (Belgium)","ror":"https://ror.org/04spfxf63","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210157284"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alain Thibault","raw_affiliation_strings":["arGEN-X BVBA, Zwijnaarde, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"arGEN-X BVBA, Zwijnaarde, Belgium","institution_ids":["https://openalex.org/I4210157284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078388793","display_name":"Philippe Georges Aftimos","orcid":"https://orcid.org/0000-0001-9946-4726","observed_orcids":["https://orcid.org/0000-0001-9946-4726"]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe G. Aftimos","raw_affiliation_strings":["Institut Jules Bordet \u2013 Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Jules Bordet \u2013 Universit\u00e9 Libre de Bruxelles, Brussels, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"15_suppl","first_page":"3023","last_page":"3023"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8539999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd70","display_name":"CD70","score":0.9649999737739563},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.6439999938011169},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.9980000257492065},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.671999990940094},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.6480000019073486},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.5979999899864197},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/sezary-syndrome","display_name":"S\u00e9zary syndrome","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6769999861717224},{"id":"https://openalex.org/keywords/infusion-related-reactions","display_name":"infusion reactions","score":0.5519999861717224},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8203674554824829},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.70824134349823},{"id":"https://openalex.org/C2908856526","wikidata":"https://www.wikidata.org/wiki/Q16252627","display_name":"Antibody therapy","level":4,"score":0.5556468963623047},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5511639714241028},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5353966355323792},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4610513746738434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36793383955955505}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2014.32.15_suppl.3023","doi":"https://doi.org/10.1200/jco.2014.32.15_suppl.3023","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2014.32.15_suppl.3023","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmh:oai:archive.ugent.be:7004678","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1854/LU-7004678","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0732-183X","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2742020830","https://openalex.org/W2033180077","https://openalex.org/W2787754778","https://openalex.org/W1979382909","https://openalex.org/W2327953146","https://openalex.org/W4297932550","https://openalex.org/W2599093128","https://openalex.org/W2077610119","https://openalex.org/W2516033880","https://openalex.org/W4387297483"],"abstract_inverted_index":{"3023":[0],"Background:":[1],"Distribution":[2],"of":[3,20,64,113,174,180,254],"CD70,":[4],"a":[5,44,111,220],"TNF":[6],"superfamily":[7],"receptor":[8],"involved":[9],"in":[10,30,34,130,151,187,205,219],"transient,":[11],"rapid-onset":[12],"immune":[13,41],"response,":[14],"is":[15,27,54,257],"normally":[16],"restricted":[17],"to":[18],"subsets":[19],"T-,":[21],"B-,":[22],"and":[23,40,96,107,109,139,178,247],"dendritic":[24],"cells.":[25],"It":[26],"chronically":[28],"over-expressed":[29],"patients":[31,68,132,207,229],"with":[32,79,222],"malignancies":[33],"whom":[35],"it":[36],"mediates":[37],"tumor":[38,82],"growth":[39],"escape.":[42],"ARGX-110,":[43],"monoclonal":[45],"IgG1":[46],"SIMPLE":[47],"Antibody":[48],"glyco-engineered":[49],"for":[50,86,232],"enhanced":[51],"ADCC":[52,177,285],"(POTELLIGENT),":[53],"undergoing":[55],"Phase":[56],"1":[57,175,272],"testing":[58],"(ClinicalTrials.gov":[59],"Identifier:":[60],"NCT01813539).":[61],"Methods:":[62],"As":[63],"December":[65],"2013,":[66],"19":[67],"(median":[69,116],"age:":[70],"56":[71],"years;":[72],"prior":[73,76],"chemo:":[74],"82%;":[75],"biologics/TKIs:":[77],"29%)":[78],">":[80,196,233],"10%":[81],"cells":[83,183],"staining":[84],"positive":[85],"CD70":[87,296],"by":[88,202],"immunohistochemistry":[89],"were":[90,149,160,185],"treated":[91,208],"at":[92,195,209],"0.1,":[93],"1,":[94],"5,":[95,105],"10":[97,276],"mg/kg":[98,256,271,273,275,277],"IV":[99],"q3":[100],"weeks;":[101],"n":[102],"=":[103,117,164],"6,":[104],"3,":[106],"5)":[108],"received":[110],"total":[112],"82":[114],"cycles":[115],"4;":[118],"range":[119],"1-11).":[120],"Results:":[121],"The":[122],"most":[123,206],"common":[124],"drug-related":[125],"adverse":[126],"events":[127],"(AE)":[128],"observed":[129,150,172],"14":[131],"were:":[133],"infusion-related":[134],"reaction":[135],"(26%),":[136],"fatigue":[137],"(21%)":[138],"diarrhea":[140],"(16%).":[141],"Drug-related":[142],"Grade":[143],"3":[144],"AEs":[145],"(hypoxia,":[146],"anorexia,":[147],"fatigue)":[148],"2":[152,255],"patients.":[153,189],"No":[154],"immune-related":[155],"AE":[156],"was":[157,171,193,217],"observed.":[158],"Pharmacokinetics":[159],"dose-linear":[161],"(T":[162],"1/2":[163],"11":[165],"days).":[166],"Saturated":[167,282,283,284],"target-mediated":[168],"clearance":[169],"(Ctarget)":[170,279],"as":[173],"mg/kg.":[176,198],"depletion":[179],"circulating":[181],"CD70+":[182],"(qPCR)":[184],"demonstrated":[186],"all":[188],"Complement-derived":[190],"cytotoxicity":[191],"(CDC)":[192],"maximal":[194],"0.1":[197,270],"Circulating":[199],"Tregswere":[200],"reduced":[201],"\u2265":[203],"50%":[204],"the":[210,245],"highest":[211],"doses.":[212],"One":[213],"CR":[214],"(in":[215],"blood)":[216],"confirmed":[218],"patient":[221],"stage":[223],"IVA":[224],"(T2NxM0B2)":[225],"S\u00e9zary":[226],"syndrome.":[227],"Five":[228],"maintained":[230],"SD":[231],"6":[234],"months":[235],"(RCC,":[236],"parotid,":[237],"myoepithelial,":[238],"platinum-resistant":[239],"ovarian,":[240],"mesothelioma).":[241],"Conclusions:":[242],"Based":[243],"on":[244],"clinical":[246],"immunological":[248],"parameters":[249],"an":[250],"intermediate":[251],"dose":[252],"level":[253],"being":[258],"studied.":[259],"Full":[260],"results":[261],"will":[262],"be":[263],"presented.":[264],"Clinical":[265],"trial":[266],"information:":[267],"NCT01813539.":[268],"Dose":[269],"5":[274],"PK":[278],"Not":[280,291],"saturated":[281,292],"Yes":[286,287,288,289],"CDC":[290],"Maximal":[293,294,295],"qPCR":[297],"70%":[298],"\u2193":[299],"61%\u2193":[300],"72%\u2193":[301],"NA":[302],"B-cell":[303],"count":[304,310],"Stable":[305,306,307,308,311,312,313,314],"T-cell":[309]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
