{"id":"https://openalex.org/W2346358086","doi":"https://doi.org/10.1371/journal.pone.0155107","title":"P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes","display_name":"P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes","publication_year":2016,"publication_date":"2016-05-09","ids":{"openalex":"https://openalex.org/W2346358086","doi":"https://doi.org/10.1371/journal.pone.0155107","mag":"2346358086","pmid":"https://pubmed.ncbi.nlm.nih.gov/27159053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4861344"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0155107","doi":"https://doi.org/10.1371/journal.pone.0155107","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0155107","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155107&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155107&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103220970","display_name":"Zeynep \u015eeref-Ferlengez","orcid":"https://orcid.org/0000-0002-0873-3079","observed_orcids":["https://orcid.org/0000-0002-0873-3079"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeynep Seref-Ferlengez","raw_affiliation_strings":["Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-0873-3079","affiliations":[{"raw_affiliation_string":"Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037761045","display_name":"Stephanie Maung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Maung","raw_affiliation_strings":["Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040053224","display_name":"Mitchell B. Schaffler","orcid":"https://orcid.org/0000-0001-5780-7073","observed_orcids":["https://orcid.org/0000-0001-5780-7073"]},"institutions":[{"id":"https://openalex.org/I125687163","display_name":"City College of New York","ror":"https://ror.org/00wmhkr98","country_code":"US","type":"education","lineage":["https://openalex.org/I125687163"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell B. Schaffler","raw_affiliation_strings":["Department of Biomedical Engineering, City College of New York, New York, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, City College of New York, New York, NY, United States of America","institution_ids":["https://openalex.org/I125687163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066760140","display_name":"David Conover Spray","orcid":"https://orcid.org/0000-0001-8368-5073","observed_orcids":["https://orcid.org/0000-0001-8368-5073"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David C. Spray","raw_affiliation_strings":["Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031292369","display_name":"Sylvia O. Suadicani","orcid":"https://orcid.org/0000-0001-6811-4029","observed_orcids":["https://orcid.org/0000-0001-6811-4029"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sylvia O. Suadicani","raw_affiliation_strings":["Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Department of Urology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Department of Urology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mia M. Thi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I1335289525","display_name":"Montefiore Medical Center","ror":"https://ror.org/044ntvm43","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1335289525","https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mia M. Thi","raw_affiliation_strings":["Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Departments of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]},{"raw_affiliation_string":"Laboratories of Musculoskeletal Orthopedic Research at Einstein-Montefiore (MORE), Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, United States of America","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I1335289525"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":9.0982,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.98618352,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":"5","first_page":"e0155107","last_page":"e0155107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pannexin-1","display_name":"pannexin 1","score":0.9629999995231628},{"id":"https://openalex.org/keywords/purinergic-receptors","display_name":"purinergic receptors","score":0.875},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.9700000286102295},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9259999990463257},{"id":"https://openalex.org/keywords/atp-release","display_name":"ATP release","score":0.7059999704360962},{"id":"https://openalex.org/keywords/p2y2-receptor","display_name":"P2Y2 receptor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/p2y4-receptor","display_name":"P2Y4 receptor","score":1.0},{"id":"https://openalex.org/keywords/ins2akita-mice","display_name":"Ins2Akita mice","score":0.7720000147819519},{"id":"https://openalex.org/keywords/fluid-shear-stress","display_name":"fluid shear stress","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.7860597968101501},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6562567353248596},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6329811811447144},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.631266713142395},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.443536639213562},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.44324856996536255},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.44215989112854004},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4365096688270569},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41609394550323486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39042773842811584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37731659412384033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32575953006744385},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18771451711654663},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11714467406272888}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0155107","doi":"https://doi.org/10.1371/journal.pone.0155107","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0155107","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155107&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4861344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4861344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:27159053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27159053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:academicworks.cuny.edu:cc_pubs-1601","doi":null,"is_oa":true,"landing_page_url":"https://academicworks.cuny.edu/cc_pubs/507","pdf_url":null,"source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications and Research","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:7b82f99149e44947bd69209a5ef39d5a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7b82f99149e44947bd69209a5ef39d5a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 11, Iss 5, p e0155107 (2016)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0155107","doi":"https://doi.org/10.1371/journal.pone.0155107","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0155107","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0155107&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.800000011920929,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1290762650","display_name":"Urothelial ATP Signaling and Diabetic Bladder Dysfunction","funder_award_id":"R01DK081435","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1870224986","display_name":"Liver Pathobiology and Gene Therapy Research Core Center","funder_award_id":"P30DK041296","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2639953458","display_name":"Ostecocyte Intergrity and Bone Remodeling","funder_award_id":"R01AR041210","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3142471505","display_name":"Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing","funder_award_id":"R01AR057139","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3524644092","display_name":null,"funder_award_id":"AR057139, AR041210","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G363488643","display_name":null,"funder_award_id":"DK091466","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3670665632","display_name":null,"funder_award_id":"AR041210","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G5052340166","display_name":"Luminescence Imaging: Molecules, Cells and Tissues","funder_award_id":"S10RR020949","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G589777270","display_name":null,"funder_award_id":"DK 081435","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6257264241","display_name":null,"funder_award_id":"AR057139","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6421529817","display_name":"Effects of High Glucose on Bone Cell Mechanosensing, Transduction, and Signaling","funder_award_id":"R01DK091466","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000900974","display_name":"NYR-Diabetes Research Center (NYR-DRC)","funder_award_id":"P30DK020541","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320311312","display_name":"University of Missouri-Kansas City","ror":"https://ror.org/01w0d5g70"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2346358086.pdf","grobid_xml":"https://content.openalex.org/works/W2346358086.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W633883572","https://openalex.org/W1652067119","https://openalex.org/W1965209860","https://openalex.org/W1965736300","https://openalex.org/W1966793235","https://openalex.org/W1971400919","https://openalex.org/W1971817436","https://openalex.org/W1972354333","https://openalex.org/W1976402969","https://openalex.org/W1976406251","https://openalex.org/W1976958448","https://openalex.org/W1977686722","https://openalex.org/W1978688152","https://openalex.org/W1981196442","https://openalex.org/W1982504786","https://openalex.org/W1996802229","https://openalex.org/W1997515464","https://openalex.org/W1999576323","https://openalex.org/W1999925297","https://openalex.org/W2000669510","https://openalex.org/W2007478852","https://openalex.org/W2007861384","https://openalex.org/W2011494353","https://openalex.org/W2013339414","https://openalex.org/W2017612052","https://openalex.org/W2019310006","https://openalex.org/W2020194821","https://openalex.org/W2025705866","https://openalex.org/W2025768760","https://openalex.org/W2029737500","https://openalex.org/W2033803440","https://openalex.org/W2034182613","https://openalex.org/W2042470118","https://openalex.org/W2044170424","https://openalex.org/W2045463244","https://openalex.org/W2047557527","https://openalex.org/W2049467938","https://openalex.org/W2053543161","https://openalex.org/W2059030264","https://openalex.org/W2060574598","https://openalex.org/W2060738711","https://openalex.org/W2066488545","https://openalex.org/W2075994380","https://openalex.org/W2077857158","https://openalex.org/W2078551078","https://openalex.org/W2079901569","https://openalex.org/W2081308255","https://openalex.org/W2083920483","https://openalex.org/W2084069949","https://openalex.org/W2085780740","https://openalex.org/W2087429630","https://openalex.org/W2087665466","https://openalex.org/W2088844806","https://openalex.org/W2090185696","https://openalex.org/W2092291596","https://openalex.org/W2093984537","https://openalex.org/W2098260625","https://openalex.org/W2102147313","https://openalex.org/W2102694854","https://openalex.org/W2107407786","https://openalex.org/W2108001469","https://openalex.org/W2108438416","https://openalex.org/W2117503439","https://openalex.org/W2119551577","https://openalex.org/W2122901687","https://openalex.org/W2125688767","https://openalex.org/W2126052469","https://openalex.org/W2128767149","https://openalex.org/W2137411152","https://openalex.org/W2141260882","https://openalex.org/W2141571472","https://openalex.org/W2166752210","https://openalex.org/W2229304551","https://openalex.org/W2313712440","https://openalex.org/W2342591351","https://openalex.org/W4404596861"],"related_works":["https://openalex.org/W2163352931","https://openalex.org/W7160503091","https://openalex.org/W2515931189","https://openalex.org/W7128434146","https://openalex.org/W1652067119","https://openalex.org/W2806986858","https://openalex.org/W2214062048","https://openalex.org/W2986503606","https://openalex.org/W2790341770","https://openalex.org/W2791959775"],"abstract_inverted_index":{"Type":[0],"1":[1,50],"diabetes":[2,26],"(T1D)":[3],"causes":[4],"a":[5,76,94],"range":[6],"of":[7,44,70,144,156,172,186],"skeletal":[8,23,71],"problems,":[9],"including":[10],"reduced":[11],"bone":[12,18,63,110,206,211,248],"density":[13],"and":[14,42,48,53,68,122,142,146,162,170,191,199,208,219,223,239],"increased":[15],"risk":[16],"for":[17,61,79,97,126,246],"fractures.":[19],"However,":[20],"mechanisms":[21],"underlying":[22],"complications":[24],"in":[25,38,82,103,114,129,183,202,209,237],"are":[27,90,112,244],"still":[28],"not":[29],"well":[30],"understood.":[31],"We":[32,73],"hypothesize":[33],"that":[34,58,87,231],"high":[35,187,203,214],"glucose":[36,106,138,188,204,215],"levels":[37,107],"T1D":[39,232],"alters":[40],"expression":[41,141,201],"function":[43,143],"purinergic":[45],"receptors":[46],"(P2Rs)":[47],"pannexin":[49],"(Panx1)":[51],"channels,":[52],"thereby":[54],"impairs":[55,233],"ATP":[56,99,174,224,235],"signaling":[57,222,236],"is":[59],"essential":[60,245],"proper":[62],"response":[64],"to":[65,92,108,159,181],"mechanical":[66],"loading":[67],"maintenance":[69],"integrity.":[72],"first":[74],"established":[75],"key":[77],"role":[78],"P2X7":[80],"receptor-Panx1":[81],"osteocyte":[83,123],"mechanosignaling":[84],"by":[85,151],"showing":[86],"these":[88],"proteins":[89],"co-expressed":[91],"provide":[93],"major":[95],"pathway":[96],"flow-induced":[98,173,220],"release.":[100,175],"To":[101],"simulate":[102],"vitro":[104],"the":[105],"which":[109,243],"cells":[111],"exposed":[113,205],"healthy":[115],"vs.":[116],"diabetic":[117,210],"bones,":[118],"we":[119],"cultured":[120],"osteoblast":[121,241],"cell":[124],"lines":[125],"10":[127,168],"days":[128],"medium":[130],"containing":[131],"5.5":[132],"or":[133],"25":[134],"mM":[135],"glucose.":[136],"High":[137],"effects":[139,185],"on":[140,189],"P2Rs":[145],"Panx1":[147],"channels":[148],"were":[149,179],"determined":[150],"Western":[152,193],"Blot":[153],"analysis,":[154],"quantification":[155],"Ca2+":[157,221],"responses":[158],"P2R":[160,190],"agonists":[161],"oscillatory":[163],"fluid":[164],"shear":[165],"stress":[166],"(\u00b1":[167],"dyne/cm(2)),":[169],"measurement":[171],"Diabetic":[176],"C57BL/6J-Ins2Akita":[177],"mice":[178],"used":[180],"evaluate":[182],"vivo":[184],"Panx1.":[192],"blotting":[194],"indicated":[195],"altered":[196],"P2X7R,":[197],"P2Y2R":[198],"P2Y4R":[200],"cells,":[207],"tissue.":[212],"Moreover,":[213],"blunted":[216],"normal":[217],"P2R-":[218],"release":[225],"from":[226],"osteocytes.":[227],"These":[228],"findings":[229],"indicate":[230],"load-induced":[234],"osteocytes":[238],"affects":[240],"function,":[242],"maintaining":[247],"health.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}